ISSN: 1052-556X United States Department of Agriculture National Agricultural Library 10301 Baltimore Blvd. Beltsville, Maryland 20705-2351 Animal Models in Biomedical Research: Swine SRB 94-01 Special Reference Briefs Document Delivery information: Read Bullet 16 on ALF for information on Document Delivery services. Read Bullet 15 for "Electronic Mail Access For Interlibrary Loan (ILL) Requests." If the text of this Special Reference Briefs file is copied and/or distributed, please include in all copies, the information provided in these bulletins. Animal Models in Biomedical Research: Swine Special Reference Briefs: QB 94-01 Updates SRB 91-06 Cynthia Petrie Smith Animal Welfare Information Center December 1993 National Agricultural Library cataloging Record: Smith, Cynthia Petrie Animal models in biomedical research : swine. (Special reference briefs ; 94-01) 1. Swine as laboratory animals--Bibliography. 2. Animal models in research--Bibliography. I. Title. aS21.D27S64 no.94-01 The United States Department of Agriculture (USDA) prohibits discrimination in its programs on the basis of race, color, national origin, sex, religion, age, disability, political beliefs, and marital or familial status. (Not all prohibited bases apply to all programs). Persons with disabilities who require alternative means for communication of program information (braille, large print, audiotape, etc.) should contact the USDA Office of Communications at (202) 720-5881 (voice) or (202) 720-7808 (TDD). To file a complaint, write the Secretary of Agriculture, U.S. Department of Agriculture, Washington, D.C. 20250, or call (202) 720-7327 (voice) or (202) 720-1127 (TDD). USDA is an equal employment opportunity employer. ANIMAL MODELS IN BIOMEDICAL RESEARCH: SWINE Table of Contents INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . GENERAL REVIEW . . . . . . . . . . . . . . . . . . . . . . . . CARDIOVASCULAR SYSTEM. . . . . . . . . . . . . . . . . . . . . HEMODYNAMICS/HEMATOLOGY . . . . . . . . . . . . . . . . . . . PULMONARY SYSTEM . . . . . . . . . . . . . . . . . . . . . . . GASTROINTESTINAL FUNCTION. . . . . . . . . . . . . . . . . . . LIVER AND PANCREAS . . . . . . . . . . . . . . . . . . . . . . NUTRITION. . . . . . . . . . . . . . . . . . . . . . . . . . . URINARY SYSTEM . . . . . . . . . . . . . . . . . . . . . . . . REPRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . IMMUNOLOGY . . . . . . . . . . . . . . . . . . . . . . . . . . STRESS . . . . . . . . . . . . . . . . . . . . . . . . . . . . SKELETAL SYSTEM. . . . . . . . . . . . . . . . . . . . . . . . DERMATOLOGY. . . . . . . . . . . . . . . . . . . . . . . . . . PERINATOLOGY . . . . . . . . . . . . . . . . . . . . . . . . . TOXICOLOGY . . . . . . . . . . . . . . . . . . . . . . . . . . PHARMACODYNAMICS . . . . . . . . . . . . . . . . . . . . . . . NERVOUS SYSTEM . . . . . . . . . . . . . . . . . . . . . . . . OPHTHALMOLOGY. . . . . . . . . . . . . . . . . . . . . . . . . PERIODONTOLOGY . . . . . . . . . . . . . . . . . . . . . . . . SURGERY AND LABORATORY TECHNIQUES. . . . . . . . . . . . . . . PRODUCTION, MANAGEMENT, BREEDING AND WELFARE . . . . . . . . . -------------------------------------------------------------- INTRODUCTION Swine have been utilized as a biomedical research model in a wide variety of disciplines; the most notable being cardiovascular research. Swine exhibit many similarities to man in cardiovascular anatomy and physiology including: a comparable heart to body size ratio, spontaneous development of atherosclerosis, coronary arterial anatomy, lipoprotein structure, propensity towards obesity, and susceptibility to a variety of stressors. Pigs are nonruminant omnivores and exhibit similarities to man in digestive physiology. Piglets and human infants share similar nutrient requirements and a susceptibility to a host of gastrointestinal pathogens. The pig has been used as a model for diabetes, alcoholism, peptic ulcers, and liver transplant studies. Swine have multilobar kidneys similar in size, number, and structure to human kidneys, which makes the pig an excellent model for kidney obstruction and reflux neuropathies. In the field of dermatology, swine have been utilized to study wound healing, plastic surgery procedures, the formation of human melanomas, and the effects of photoaging. Swine also have been utilized as models in skeletal research, toxicology, and pharmacology. Advantages to using swine as animal models include: relatively low cost, availability, and the ability of swine to produce large litters of hardy newborns. In addition, a great wealth of agricultural literature has been produced that may have applications in biomedical research--particularly in the areas of nutrition, reproduction, and behavior. Pigs are an intelligent and versatile species that can adapt to a variety of experimental conditions, provided their environmental and behavioral needs are met (533, 537, 539). As swine continue to gain popularity as a biomedical research model, there is a need for more information on the management, handling, care, and welfare of swine in laboratory settings. This Special Reference Brief is a general reference tool for individuals interested in the use of swine as biomedical models. It is not meant to be a complete review of all literature existing on swine in biomedical research, but rather a sampling of the current literature. Individuals interested in using swine for a specific model, should consult with their librarian and have a literature search tailored to meet their specific needs. A variety of biological, medical and agricultural literature databases including MEDLINE, TOXLINE, EMBASE, BIOSIS, AGRICOLA, and CAB Abstracts, contain excellent references on the use of swine as biomedical models. The following Special Reference Brief, contains bibliographic citations of articles and books obtained from a variety of scientific and agricultural sources dating from January 1980 to September 1990. Citations from materials that are present in the collection of the National Agricultural Library have been assigned an NAL call number. Citations are arranged in chronological order from the most to the least recent. The author wishes to acknowledge M. Michael Swindle, D.V.M. for his expert review of this document. Dr. Swindle is well known for his many writings and presentations on the use of swine as surgical models. The author also extends her appreciation to Catherine Shull, for her tireless enthusiasm and diligence while working on the update of this document. -------------------------------------------------------------- GENERAL REVIEW 1 Swine as Models in Biomedical Research M.M. Swindle, D.C. Moody, and L.D. Phillips (eds.), Iowa State University Press, IA; 1992, 312p. NAL call number: RB125 S79 Descriptors: miniature swine, pancreatic beta-cell transplantation, renal transplantation, liver transplantation, pediatric surgery, peritoneal dialysis, vascular pharmacology, anesthetics, hypercholesterolemia, myocardial ischemia, congenital cardiovascular disease, hemorrhagic shock, intraperitoneal sepsis, wound-healing, hypertension. 2 "MHC-homozygous miniature swine." D.H. Sachs. In: Swine as Models in Biomedical Research M.M. Swindle, D.C. Moody, and L.D. Phillips (eds.), Iowa State University Press, IA; 1992, pp. 3-15. NAL call number: RB 125 S79 Descriptors: genetics, inbreeding, transplant immunity, graft survival. 3 A Colour Atlas of Diseases and Disorders of the Pig W.J. Smith, D.J. Taylor, and R.H.C. Penny. Wolfe Publishing Ltd, Ipswich, England; 1990, 192p. NAL call number: SF971 S59 Descriptors: developmental abnormalities, nutritional disorders, trauma disorders, parasites, bacteria, viruses, behavioral problems, vices. 4 "Normal physiological values for conscious pigs used in biomedical research." J.P. Hannon, C.A. Bossone, and C.E. Wade. Laboratory Animal Science 40(3):293-298(May 1990). NAL call number: 410.9 P94 Descriptors: acid base equilibrium, blood gas monitoring, transcutaneous, electrolytes, hemoglobins, hormones, kidney physiology, oxygen consumption, respiratory function tests. 5 "Animal models: The pig." J. Rapacz and J. Hasler-Rapacz. In: Monographs in Human Genetics, Vol 12. Genetic Factors in Atherosclerosis: Approaches and Model Systems A.J. Lusis and R.S. Sparkes (eds.), Karger Ag, Basel, Switzerland, New York, NY; 1989, pp139-169. Descriptors: lipoprotein, polymorphism, hereditary aspects, hypercholesterolemia, atherosclerosis. 6 Research Utilization of Miniature Swine Charles River Laboratories, MA; 1989, 83p. NAL call number: Z6658.R47 Descriptors: bibliography, models, atherosclerosis, dermatology, gastrointestinal function, breeds, handling, housing, hematology, nephrology, nervous system, parasitology, perinatology, reproduction, surgery. 7 Experimental Surgery and Physiology: Induced Animal Models of Human Disease M.M. Swindle and R.J. Adams. Williams and Wilkins, Baltimore, MD; 1988, 350p. NAL call number:RB 125 E9 Descriptors: animal models, wound healing, musculoskeletal system, urogenital system, cardiovascular system, pulmonary system, ophthalmic system, otology, laryngology, oral surgery, pancreas, alimentary tract, liver, endocrine system, nervous system, organ transplantation, neonatal surgery, interventional radiology, anesthesia. 8 "Swine as models in experimental surgery." M.M. Swindle, A.C. Smith, and B.J. Hepburn. Journal of Investigative Surgery 1(1):65-79(1988). Descriptors: anesthetic selection, housing, anatomic and physiologic characteristics. 9 "The minipig as a model in gnotobiology." L. Mandel and J. Travnicek. Nahrung 31(5-6):613-618(1987). NAL call number: 389.8 N142 Descriptors: germ free life, diet, radiation, immunity. 10 "The use of animals in biomedical research and testing." Foundation for Biomedical Research. Clinical Research Practices and Drug Regulatory Affairs 4-5:265-282(1987). Descriptors: economic aspects, social aspects, animal models, monkey, cattle, swine, sheep, cat, dog, mouse, rat. 11 "Characteristics of swine as biomedical research subjects." M.E. Tumbleson. Laboratory Animal Science 36(5):555-556(1986). NAL call number: 410.9 P94 Descriptors: abstract, nutrition, reproduction, atherosclerosis. 12 "Pigs: From B.C. to 2000 A.D.: From outhouse to penthouse." L.K. Bustad and V.G. Horstman. In: Swine in Biomedical Research M.E. Tumbleson (ed.), Vol. 1. Plenum Press, New York, NY; 1986, pp. 3-15. NAL call number: RB125.C68 1985. Descriptors: history, medical research, husbandry, miniature swine, intelligence, behavior, socialization. 13 "Swine in biomedical research." L.M. Panepinto and M.M. Swindle (eds.) Laboratory Animal Science 36(4):343-433(August 1986). NAL call number: 410.9 P94 Descriptors: Yucatan miniature pig, myocardial ischemia, exercise, cardiopulmonary surgery, anesthetics, reproductive and thermoregulatory behavior, stress, handling, housing, endotoxemia, immunology, interstitial radiation studies, herpes encephalitis, fetal calcium homeostasis, liver transplantation, plastic surgery, blood sampling methods. 14 Swine in Biomedical Research M.E. Tumbleson (ed.), Vol. 1-3. Plenum Press, New York; 1986, 1988p. NAL call number: RB125.C68 1985. Descriptors: history, models, management, nutrition, immunology, hematology, cardiovascular studies, perinatology, renal functioning, medicine. 15 Basic Surgical Exercises Using Swine M.M. Swindle. Praeger Publishers, New York, NY; 1983, 277p. NAL call number: RD29.5 S94S94 Descriptors: anesthesia, euthanasia, instrumentation, operative procedures, sterile surgery, suture materials and techniques. 16 "The pig model for biomedical research." W.J. Dodds. Federation Proceedings 41(2):247-256(1982). NAL call number: 442.9 F3IP Descriptors: heart disease, lipid metabolism. CARDIOVASCULAR SYSTEM 17 "Echocardiographic and anatomic correlation of ventricular septal defect morphology in newborn Yucatan pigs." T.B. Johnson, D.A. Fyfe, R.P. Thompson, C.H. Kline, M.M. Swindle, and R.H. Anderson. American Heart Journal 125(4):1067-1072(1993). Descriptors: heart septal defects, ventricular pathology, ultrasonography. 18 "An experimental algorithm versus standard advanced cardiac life support in a swine model of out-of-hospital cardiac arrest." J.J Menegazzi, E.A. Davis, D.M. Yealy, R.L. Molner, K.A. Nicklas, G.M. Hosack, E.A. Honingford, and M.M. Klain. Annals of Emergency Medicine 22(2):235-239(1993). Descriptors: algorithms, heart arrest therapy, life support care, bretylium, therapeutic use, cardiopulmonary resuscitation, epinephrine therapeutic use. 19 "How much `significance' is significant? The transition from animal models to human trials in resuscitation research." D.M. Yealy. Annals of Emergency Medicine 22(1):11-16(1993). Descriptors: resuscitation, emergency medicine, primate, dog, swine, heart electrophysiology, hemodynamics, reproducibility. 20 "Atherosclerotic Yucatan microswine as a model for novel cardiovascular interventions and imaging." D. Gal and J.M. Isner. In: Swine as Models for Biomedical Research M.M. Swindle, D.C. Moody, and L.D. Phillips (eds.), Iowa State University Press, IA; 1992, pp. 118-140. NAL call number: RB125 S79 Descriptors: atherogenic diet, balloon endothelial denudation, iliac arteries, iliofemoral arteriograms. 21 "Congenital cardiovascular disease." M.M. Swindle, R.P. Thompson, B.A. Carabello, A.C. Smith, C.T. Green, and P.C. Gillette. In: Swine as Models in Biomedical Research M.M. Swindle, D.C. Moody, and L.D. Phillips (eds.). Iowa State University Press, IA; 1992, pp. 176-184. NAL call number: RB125 S79 Descriptors: ventricular septal defect, patent ductus arteriosus, atrial septal defect, left hypoplastic heart syndrome. 22 "Effects of chronic tachycardia-induced cardiomyopathy on the beta-adrenergic receptor system." S.A. Burchell, F.G. Spinale, F.A. Crawford, R. Tanaka, and M.R. Zile. Journal of Thoracic and Cardiovascular Surgery 104(4):1006-1012(1992). Descriptors: supraventricular tachycardia, swine, noradrenalin blood level, binding kinetics, echocardiography, heart catheterization. 23 "Intracardiac therapy following emergency thoracotomy in the accident and emergency department: An experimental model." C. Moulton, A. Pennycook, R. Crawford. Archives of Emergency Medicine 9(2):190-195(1992). Descriptors: thoracotomy, emergency medicine, balloon catheter. 24 "Myocardial oxygenation and transmural lactate metabolism during experimental acute coronary stenosis in pigs." P. Gonschior, G.M. Gonschior, P.F. Conzen, J. Hobbhahn, A.E. Goetz, K. Peter, and W. Brendel. Basic Research In Cardiology 87(1):27-37(1992). Descriptors: lactic acid, drug concentration, tissue oxygenation, coronary artery obstruction, blood sampling, male, female. 25 "The pig as a model of myocardial ischemia and gradual coronary artery occlusion." C.M. Bloor, F.C. White, and D.M. Roth. In: Swine as Models in Biomedical Research M.M. Swindle, D.C. Moody, and L.D. Phillips (eds.), Iowa State University Press, IA; 1992, pp. 163-175. NAL call number: RB125 S79 Descriptors: Yucatan, Hampshire, maximal oxygen consumption, experimental surgery, amaroid occluder. 26 "Review of all studies of cardiopulmonary resuscitation in animal models reported in the emergency medicine literature for the past 10 years." C.J. Holliman and M.A. Bates. American Journal of Emergency Medicine 10(4):347-353(1992). Descriptors: bicarbonate, phenylephrine, bretylium, swine, dog, compression therapy, bypass, rat. 27 "The spontaneously hypercholesterolemic pig as an animal model of human hypercholesterolemia." A.D. Attie, R.J. Aiello, and W.J. Checovich. In: Swine as Models in Biomedical Research M.M. Swindle, D.C. Moody and L.D. Phillips (eds.), Iowa State University Press, IA; 1992, pp. 141-155. NAL call number: RB125 S79 Descriptors: low density lipoprotein, mutant pigs, apoproteins, lipid metabolism. 28 "Studies in the physiology of cardiopulmonary bypass using a swine model." D.E. Cameron, V.K.H. Tam, W. Cheng, and M. Braxton. In: Swine as Models in Biomedical Research M.M. Swindle, D.C. Moody and L.D. Phillips (eds.), Iowa State University Press, IA; 1992, pp. 185-196. NAL call number: RB125 S79 Descriptors: cardiac surgery, cerebral blood flow, focal ischemic injury, platelet count. 29 "The Yucatan miniature swine: An atherogenic model to assess the early patency rates of an endovascular stent." C.J. White, S.R. Ramee, A.K. Banks, D. Wiktor, and H.L. Price. In: Swine as Models in Biomedical Research M.M. Swindle, D.C. Moody, and L.D. Phillips (eds.), Iowa State University Press, IA; 1992, pp. 156-162. NAL call number: RB125 S79 Descriptors: balloon expandable endovascular stent, angiography, stent implantation. 30 "Buffer solutions may compromise cardiac resuscitation by reducing coronary perfusion pressure." F. Kette, M.H. Weil, and R.J. Gazmuri. Journal of the American Medical Association 266(15):2121-2126(1991). NAL call number: 448.9 Am 37 Descriptors: coronary artery blood flow, hypertonic solution, heart arrest, sodium carbonate, sodium chloride. 31 "A closed-chest porcine model of chronic left ventricular systolic and diastolic dysfunction after myocardial infarction." K.B. Kern, L.D. Lancaster, M. Olajos, and S. Goldman. Coronary Artery Disease 2(6):685-690(1991). Descriptors: hemodynamics, ischemic cardiomyopathy, coronary occlusion. 32 "Effects of acute right ventricular ischemia on ventricular interactions during prosthetic left ventricular support." D.J. Farrar, E. Chow, P.G. Compton, L. Foppiano, J. Woodard, and J.D. Hill. Journal of Thoracic and Cardiovascular Surgery 102(4):588-595(1991). Descriptors: assisted circulation, heart function, right ventricle function, male, female. 33 "Ventricular septal defects in a family of Yucatan miniature pigs." S.Y. Ho, R.P. Thompson, S.R. Gibbs, M.M. Swindle, and R.H. Anderson. International Journal of Cardiology 33(3):419-25(1991). Descriptors: heart septal defects, ventricular epidemiology. 34 "Heritable ventricular septal defect in Yucatan miniature swine." M.M. Swindle, R.P. Thompson, B.A. Carabello, A.C. Smith, B.J. Hepburn, D.R. Bodison, W. Corin, A. Fazel, W.W.R. Biederman, and F.G. Spinale. Laboratory Animal Care 40(2):155-161(1990). NAL call number: 410.9 P94 Descriptors: heart septal defects, genetics, swine diseases. 35 "Importance of experimental models for the development of clinical trials on thromboatherosclerosis." V. Fuster, J.H. Ip, L. Badimon, B. Stein, and J.H. Chesebro. Circulation 83(6):IV-15-IV-25(1991). NAL call number: RC 681 A1C8 Descriptors: coronary artery atherosclerosis, drug therapy, heparin, acetylsalicylic acid, antithrombocytic agent, ipyridamole, dipyridamole. 36 "Isovolumic contraction as manifested in the aortic pressure contour." J.J. Ferguson, P. Sahagian, and M.J. Miller. Journal of Applied Cardiology 6(6):349-357(1991). Descriptors: left ventricular contractility, aorta valve, manometry, m mode echocardiography, heart ventricle extrasystole, aorta stenosis, vascular resistance. 37 "Methods of cardiac preservation alter the function of the endothelium in porcine coronary arteries." F.N. Nilsson, V.M. Miller, P.M. Vanhoutte, and C.G.A. McGregor. Journal of Thoracic and Cardiovascular Surgery 102(6):923-930(1991). Descriptors: calcimycin, cardioplegic agent, indomethacin, talipexole, bradykinin, alpha 2 adrenergic receptor stimulating pharmacology, heart preservation. 38 "Resuscitation of hypercalcemic arrest. Lack of efficacy of verapamil, magnesium, and bicarbonate in a swine model." B.A. Smith, J.G. Reid, G.P. Moore, D.B. Ferguson, and K.C. O'Hair. Current Therapeutic Research Clinical and Experimental 49(3):458-463(1991). Descriptors: calcium chloride, calcium antagonist, heart arrest. 39 "Right ventricular pump dysfunction with acute experimental septic shock." J.L. Zellner, F.G. Spinale, F.A. Crawford Jr., and J.A. Cook. Journal of Surgical Research 50(1):93-99(1991). Descriptors: thermodilution, heart function, male, female. 40 "Species differences in the infectability of vascular grafts." M.A. Ricci, R.J. Mehran, D. Petsikas, F. Mohamed, R. Guidoin, N.V. Christou, A. Graham, and J.F. Symes. Journal of Investigative Surgery 4(1):45-52(1991). Descriptors: graft infection, blood vessel graft, dog, swine, electron microscopy, male, female. 41 "Surgical model of volume overload-induced ventricular myocardial hypertrophy (VH(vo)) to study a clinical problem in humans." C. Wittnich, M.P. Belanger, B.S. Oh, and T.A. Salerno. Journal of Investigative Surgery 4(3):333-338(1991). Descriptors: microcrystalline collagen, drug therapy, heart surgery, experimental model, postoperative complication, hypervolemia, arteriovenous shunt, anastomosis. 42 "Animal model of coronary spasm." H. Tomoike. Journal of Molecular and Cellular Cardiology 22(Suppl. 2):S25(1990). Descriptors: human, pig, angina, myocardial infarction, myocardial ischemia. 43 "Application of a new phased array ultrasound imaging catheter in the assessment of vascular dimensions in vivo comparison to cineangiography." S.E. Nissen, C.L. Grines, J.C. Gurley, K. Sublett, D. Haynie, C. Diaz, D.C. Booth, and A.N. Demar. Circulation 81(2):660-666(1990). NAL call number: RC681.A1C8 Descriptors: dog, pig, model, stenosis, cross sectional area diameter. 44 "Atherosclerotic Yucatan microswine: An animal model with high-grade fibrocalcific, nonfatty lesions suitable for testing catheter-based interventions." D.Gal, A.J. Rongione, G.A. Slovenkai, S.T. DeJesus, A. Lucas, C.D. Fields, and J.M. Isner. The American Heart Journal 119(2 Part 1):291-300(February 1990). Descriptors: arteriosclerosis, atherosclerosis, angiography, radiography, catheterization, economics. 45 "Can atherosclerosis plaques regress? Anatomic and biochemical evidence from nonhuman animal models." R.W. Wissler and D. Vesselinovitch. American Journal of Cardiology 65(12):33F-40F.(March 20, 1990). NAL call number: RC681 A1A56 Descriptors: arteriosclerosis, atherosclerosis, diet, drug therapy, blood vessels, macaca mulatta, swine. 46 "Cardiac function and morphology of Hanford miniature swine and Yucatan miniature and micro swine." A.C. Smith, F.G. Spinale, and M.M. Swindle. Laboratory Animal Science 40(1):47-50(1990). NAL call number: 410.9 P94 Descriptors: blood pressure, blood vessels, anatomy, histology, hemodynamics, species specificity, vascular resistance. 47 "Comparative antithrombotic efficacy of the cycloxygenase inhibitor aspirin and the thromboxane synthetase inhibitor CV-4151 after arterial injury in pigs." J.Y.T. Lam, C. Lachapelle, G.Linton, and D.Waters. Journal of the American College of Cardiology 15(2 Suppl. A):86A(1990). Descriptors: E-7 phenyl-7-3-pyridinyl-6-heptenoic acid, anticoagulant, enzyme inhibitor, platelet deposition, thromboxane, prostaglandin I2. 48 "Current concepts and animal models of sudden cardiac death for drug development." P.S. Chan and P. Cervoni. Drug Development Research 19(2):199-207(1990). Descriptors: human, dog, pig, propranolol, quinidine, procainamide, phenytoin, verapamil, clofilium, sotalol, bretylium, diltiazem, prazosin, mexiletine, nadolol, flecainide, bethanidine, meobetine, antiarrhythmic drugs, ischemia, myocardial infarction. 49 "Effect of balloon inflation on smooth muscle cell proliferation in the porcine carotid artery." M.W.I. Webster, J.H. Chesebro, M. Heras, J.S. Mruk, D.E. Grill, and V. Fuster. Journal of the American College of Cardiology 15(2 Suppl. A):165A(1990). Descriptors: vascular injury, restenosis. 50 "The effect of coronary collateral recruitment on ventricular recovery after brief coronary occlusion in dogs and pigs." S.A. Hanan, M.E. Jessen, G.E. Tuchy, R.P. Maddox, A.S. Abd- Elfattah, and A.S. Wechsler. Current Surgery 47(1):23-25.(1990). Descriptors: ischemia, reperfusion, ATP levels. 51 "The effectiveness of bystander CPR in an animal model." J.W. Hoekstra, K. Rinnert, P. Van Ligten, R. Neumar, H.A. Werman, and C.G. Brown. Annals of Emergency Medicine 19(8):881-886(August 1990). Descriptors: heart arrest, resuscitation, coronary circulation, epinephrine, hemodynamics, swine. 52 "Hemodynamics and coronary blood flow during experimental aortic valvuloplasty comparison of the dual versus the single catheter methods." J.W. Moore, M.S. Slack, W.C. Kirby, and G.M. Graeber. The American Heart Journal 119(1):136-142(1990). Descriptors: swine, left ventricular occlusion, statistics. 53 "Hyperlipidemic swine as an animal model for coronary artery plaque hemorrhages." B.Raugaard, B.H. Weiner, J.J. Hoogasian, P.H. Levine, M. Fisher, I.S. Ockene, and H.F. Cuenoud. The FASEB Journal 4(4):A1154(1990). NAL call number: QH301.F3 Descriptors: vessel, abrasion, luminal, myocardial infarction, lipid rich diet. 54 "Ischemic preconditioning reduces infarct size in swine myocardium." R.J. Schott, S. Rohmann, E.R. Braun, and W. Schaper. Circulation Research 66(4):1133-1142(1990). NAL call number: RC681 A1A57137 Descriptors: oxygen consumption, reperfusion, injury. 55 "Limitation of myocardial infarct size by superoxidase dismutase as an adjunct to reperfusion after different durations of coronary occlusion in the pig." U. Naslund, S. Haggmark, G. Johansson, S.L. Marklund, and S. Reiz. Circulation Research 66(5):1294-1301(1990). NAL call number: RC681 A1A57137 Descriptors: cardiovascular drug, oxygen, radical. 56 "Long term pathologic findings after in vivo placement of percutaneous balloon expandable tantalum stents." S.K Chokshi, J. Hogan, V. Parsonnet, F. Cross, C. White, and J.M. Isner. Laboratory Investigation 62(1):19A(1990). NAL call number: 448.8 L11 Descriptors: dog, pig, angiography, angioplasty, histology. 57 "Measurement of mean circulatory filling pressure and vascular compliance in domestic pigs." R.I. Ogilvie, D. Zborowska-Sluis, and B. Tenaschuk. American Journal of Physiology: Heart and Circulatory Physiology 258(6 Part 2):H1925-H1932(1990). Descriptors: venous return, circulatory arrest, capacitance. 58 "Nisoldipine improves blood flow to skeletal muscles in conscious pigs with chronic heart failure." W.J. Van Der Giessen, L.J. Van Woerkens, P.R. Saxena, J.R.T.C. Roelandt, and P.D. Verdouw. European Heart Journal 11(6):552-559(1990). Descriptors: cardiovascular drug, coronary collateral flow, myocardial infarction. 59 "Paramagnetic pyrophosphate preliminary studies on magnetic resonance contrast enhancement of acute myocardial infarction." A.H. Mauer, L.C. Knight, J.A. Siegel, I.B. Elfenbein, and L.P. Adler. Investigative Radiology 25(2):153-163(1990). Descriptors: technetium 99M labeled pyrophosphate, toxicology, respiratory effects. 60 "Pharmacokinetics of lidocaine after intravenous and endobronchial administration during cardiopulmonary resuscitation." U. Hoernchen, P.M. Lauven, J. Schuettler, A. Dorer, and H. Stoeckel. Der Anaesthetist 39(2):107-112(1990). Descriptors: local anesthetic, cardiac arrest, gas chromatography, elimination, half life, clearance, absorption, bioavailability. 61 "Rapid ventricular pacing in pigs: An experimental model of congestive heart failure." E. Chow, J.C. Woodard, and D.J. Farrar. American Journal of Physiology 258(5):1603-11605(1990). NAL call number: 447.8 Am3 Descriptors: heart output, heart rate, hemodynamics, biventricular dilation. 62 "Relationship between myocardial metabolites and contractile abnormalities during graded regional ischemia phosphorus-31 NMR studies of porcine myocardium in vivo." S. Schaefer, G.G. Schwartz, J.R. Gober, A.K. Wong, S.A. Camacho, B. Massie, and M.W. Weiner. The Journal of Clinical Investigation 85(3):706-713(1990). NAL call number: 448.8 J8295 Descriptors: phosphate, creatinine, coronary stenosis. 63 "Recovery after cold cardioplegic arrest of isolated blood- perfused hearts excised from non-anesthetized pigs." H.H. Kimose, J. Ravkilde, M.A. Knudesen, P. Helligso, and U. Baandrup. European Surgical Research 22(6):323-335(1990). Descriptors: heart ventricle, organ preservation, animal tissue. 64 "Acetylcholine and carbamylcholine inhibit the sodium potassium ATPase in sarcolemma from rabbit and porcine hearts by acting on muscarinic receptors coupled with pertussis toxin sensitive G-I protein." V.A. Tkachuk, M.P. Panchenko, O.V. Esyrev, and M.P. Danylenko. Journal of Molecular and Cellular Cardiology 21(Suppl. 2):S179(1989). Descriptors: pharmacological tool, GDP, GTP, ATP. 65 "Acute hemodynamic response to intravenous enoximone: An animal study and preliminary report in infants after cardiac surgery." D. Schranz, R. Huth, M. Dahm, S. Iversen, E. Hein, H. Stopfkuchen, and B.K. Jungst. Journal of Cardiovascular Pharmacology 14(Suppl. 1):s62-s68(1989). Descriptors: enoximone, dopamine, dobutamine, adrenalin, noradrenalin, drug therapy, forward heart failure, hemodynamics, venous oxygen tension, infant. 66 "Adrenocorticoids as major governing factors in incidence of aortic atherosclerosis in pigs." N. Singh and S.K. Mukherjee. Journal of Molecular and Cellular Cardiology 21(Suppl. 2):S169(1989). Descriptors: blood cholesterol, corticosterone. 67 "Adverse hemodynamic effects of pericardial closure after sternotomy and pericardiotomy." A.G. Fraser, G.D. Angelini, M.M.G. Koning, J.H. Smyllie, I. Zorn, G.R. Sutherland, and P.D. Verdouw. Circulation 80(4 Suppl. 2):11560(1989). NAL call number: RC681 A1C8 Descriptors: pig, model, open heart surgery, cardiac output, stroke volume, systemic vascular resistance, echocardiography. 68 "Angiogenesis in myocardial ischemia." W. Schaper and J. Schaper. Journal of Molecular and Cellular Cardiology 21(Suppl.2):S165(1989). Descriptors: canine, porcine, coronary artery occlusion, vascular, growth. 69 "Can superoxide dismutase alter myocardial infarct size." R. Engler and E. Gilpin. Circulation 79(5):1137-1142(1989). NAL call number: RC681 A1C8 Descriptors: dog, pig, rabbit, cardiovascular drug, reperfusion therapy. 70 "Cardiovascular and metabolic adequacy and survival after aorto-aortic bypass." A. Borzone, I. Giovannini, C. Iannace, C. Vulpio, C. Chaiarla, G. D'Andrea, G. Salgarello, G.M. Sbarra, M. Castagneto, and G.C. Castiglioni. Vascular Surgery 23(5):337-342(1989). Descriptors: pig, model, hemodynamics, respiration, myocardial competence, mortality. 71 "Drug therapy of cardiopulmonary resuscitation in children." A. Zaritsky. Drugs 37(3):356-374(1989). Descriptors: adrenalin, lidocaine, bretylium, isoprenaline, bicarbonate, dopamine, methoxamine, phenylephrine, drug therapy, cardiopulmonary arrest, calcium, blood flow. 72 "Effects of azapropazone on neutrophil migration in anesthetized swine using a multiblister suction technique." S.A. Mousa, R. Brown, J. Hsieh, and R.D. Smith. Journal of Molecular and Cellular Cardiology 21(Suppl. 2):S173(1989). Descriptors: antiinflammatory drug, immunologic drug, myocardial cytoprotection, in vivo animal model. 73 "Effects of halothane on arrhythmias induced by myocardial ischemia." B.A. Macleod, R. McGroarty, R. H. Morton, and M.J.A. Walker. Canadian Journal of Anaesthesia 36(3 Part 1):289-294(1989). Descriptors: rat, pig, pentobarbital, antiarrhythmic drug, species dependent. 74 "The effect of ischemic preconditioning on myocardial oxygen consumption and infarct size and pigs." R. Schott, S. Rohmann, E. Braun, B. Winkler, S. Juergens, and W. Schaper. Journal of Molecular and Cellular Cardiology 21(Suppl. 2):S161(1989). Descriptors: reversible post ischemic ventricular dysfunction, reperfusion, blood flow. 75 "Effect of various propofol plasma concentrations on regional myocardial contractility and left ventricular afterload." A. Coetzee, P. Fourie, J. Coetzee, E. Badenhorst, A. Rebel, C. Bollinger, R. Ubel, C. Wium, and C. Lombard. Anesthesia and Analgesia 69(4):473-483(1989). Descriptors: pig, general anesthetic drug, heart rate, stroke volume, cardiac output, arterial elastance, systolic pressure. 76 "Glucose dependence of sequential norepinephrine contractions of vascular smooth muscle." G.R. Adams and P.F. Dillon. Blood Vessels 26(2):77-83(1989). Descriptors: pig, force production, NMR. 77 "Importance of vascular effects of different cardiotonic agents in comparison to its myocardial effects." P. Metzenauer and R. Dedecke. Naunyn-Schmiedeberg's Archives of Pharmacology 339(Suppl.):R60(1989). NAL call number: 448.8 Ar2 Descriptors: pig, amironine enzyme inhibitor drug, aliferidine, pirbuterol dihydralazine, cardiovascular drug, vasodilator, cardiac output, myocardial oxygen consumption, positive inotropic stimulation, phosphodiesterase activity, ischemic heart failure. 78 "Mechanisms of arterial thrombosis in nonparallel streamlines: Platelet thrombi grow on the apex of stenotic severely injured vessel wall. Experimental study in the pig model." L. Badimon and J.J. Badimon. The Journal of Clinical Investigation 84(4):1134-1144(1989). NAL call number: 448.8 J8295 Descriptors: acute coronary syndromes, plaque rupture. 79 "Microvascular and collateral adaption in swine hearts following progressive coronary artery stenosis." G. Goerge, T. Schmidt, B.R. Ito, G.A. Pantely, and W. Schaper. Basic Research in Cardiology 84(5):524-535(1989). Descriptors: dog, model, myocardial infarction, angiogenesis, angiogram, collateral blood flow. 80 "Myocardial surface oxygen partial pressure an indicator of myocardial tissue oxygenation." J. Hobbhahn, P.F.M. Conzen, A. Goetz, G. Seidl, P. Gonschior, W. Brendel, and K. Peter. Cardiovascular Research 23(6):529-540(1989). NAL call number: QM178 A1C38 Descriptors: pig model, oxygen consumption, pacing induced tachycardia. 81 "New nonisotopic in vivo technique of quantitating cellular proliferation in arterial media and intima." M.W.I. Webster, J.H. Chesebro, M. Heras, J.S. Mruk, H. Lamb, B. Wendland, L. Badimon, and V. Fuster. Circulation 80(4 Suppl. 2):11523(1989). NAL call number: RC681 A1C8 Descriptors: pig, smooth muscle cell, bromodeoxyuridine, iododeoxyuridine, model, atherosclerosis, thrombosis, angioplasty. 82 "Parasympathetic and sympathetic innervation of the heart in the developing piglet." D.A. Hopkins, J.A. Armour, N. Gootman, and P.M. Gootman. Society of Neuroscience Abstracts 15(1):592(1989). Descriptors: perikarya, sympathetic ganglia, sensory ganglia, stellate ganglia, middle cervical ganglia, brainstem, ventrolateral nucleus ambiguus. 83 "Pharmacology of aprotinin and efficacy during cardiopulmonary bypass." T.E. Emersen, Jr. Cardiovascular Drug Revues 7(2):127-140(1989). Descriptors: human, cat, dog, pig, rat, hematologic drug, cardiovascular drug, reduction in postoperative blood loss. 84 "Pharmokinetics and central hemodynamic effects of doxorubicin and 4 epidoxorubicin in the pig." M. Andersson, L. Domellof, S. Eksborg, S. Haggmark, G. Johansson, S. Reiz, and A. Herslof. Acta Oncologica 28(5):709-714(1989). Descriptors: Antineoplastic drug, cardiotoxicity, pulmonary physiology, myocardial oxygenation. 85 "Protection of the myocardium against postischemic reperfusion damage." W.H. Van Gilst. Journal of Cardiovascular Pharmacology 14(Suppl. 9):S49-S54(1989). Descriptors: rat, dog, pig, verapamil, nifedipine diltiazem, superoxide dismutase, catalase, allopurinol, prostacyclin, captopril, cardiovascular drug pharmacodynamics, calcium antagonist, oxygen free radical, angiotensin converting enzyme inhibition. 86 "Reconstitution of calcium channel CACH purified from porcine ventricular muscle into liposomes and its characterization." T. Naitoh, T. Toyo-Oka, and T. Sugimoto. Journal of Molecular and Cellular Cardiology 21(Suppl. 2):S177(1989). Descriptors: Bay-K-8644, pharmacology, potassium, depolarization. 87 "Reduction of cephalic arteriovenous shunting by ergotamine is not mediated by HT-1 like or 5 HT-2 receptors." A.H. Bom, J.P.C. Heiligers, P.R. Saxena, and P.D. Verdouw. British Journal of Pharmacology 97(2):383-390(1989). NAL call number: 396.8 B77 Descriptors: cat, pig, 5 hydroxytryptamine, ketanserin, methiothepin, pharmacology, arteriovenous anastomoses, carotid blood flow. 88 "The regional distribution of adenosine regulating enzymes in the left and right ventricle walls of control and hypertrophic heart." V. De Tata, S. Gini, I. Simonetti, V. Fierabracci, Z. Gori, P.L. Ipata, and E. Bergamini. Basic Research in Cardiology 84(6):597-605(1989). Descriptors: rat, ox, pig, models, 5 nucleotidase adenosine deaminase, amp deaminase adenosine kinase. 89 "Response of myocardial metabolites to graded regional ischemia phosphorus-31 NMR spectroscopy of porcine myocardium in vivo." S. Schaefer, S.A. Camacho, J. Gober, R.G. Obregon, M.A. Degroot, E.H. Botvinick, B. Massie, and M.W. Weiner. Circulation Research 64(5):968-976(1989). NAL call number: RC681 A1A57137 Descriptors: coronary stenosis, phosphate, pH, regional blood flow reduction, ATP phosphocreatine, inorganic phosphate. 90 "The role of neutrophils and free radicals in the ischemic reperfused heart why the confusion and the controversy." K.A. Reimer, C.E. Murry, and V.J. Richard. Journal of Molecular and Cellular Biology 21(12):1225-1240(1989). Descriptors: dog, rabbit, pig, model, myocardium, myocyte cell, death, oxygen metabolism, myocardial infarction. 91 "Steroid induced myocardial preservation is associated with decreased cell membrane microviscosity." R.M. Engleman, M.R. Prasad, J.A. Rousou, R.H. Breyer, M. Bagchi, and D.K. Das. Circulation 80(5 Suppl. 3):11136-11143(1989). NAL call number: RC681 A1C8 Descriptors: pig, dexamethasone, hormone, cardiovascular, myocardial ischemia, phospholipid degradation. 92 "Stimulatory effect of catalytic subunit of cyclic AMP dependent protein kinase on lipid methylation in isolated cardiac sarcolemma." R. Vetter, V. Panagia, J. Dai, Y. Taira, and N.S. Dhalla. Journal of Molecular and Cellular Cardiology 21(Suppl. 2):S180(1989). Descriptors: rat, pig, sarcolemmal membrane. 93 "Superoxide dismutase: Possible therapeutic use in cardiovascular disease." R. Ferrari, C. Ceconi, S. Curello, S. Ghielmi, and A. Albertini. Pharmacological Research 21(Suppl.2):57-65(1989). Descriptors: heart muscle ischemia, reperfusion, heat protection, oxygen radical inflammation, drug bioavailability, osteoarthritis, dog, rabbit, swine. 94 "Transesophageal low energy cardioversion in an animal model of life threatening tachyarrhythmias." Y.C. Cai, S.L. Fan, D.X. Feng, S.X. Fan, J.F. Feng, Z.S. Kuang, and Z.F. Li. Circulation 80(5):1354-1359(November 1989). NAL call number: RC681.A1C8 Descriptors: electric countershock, tachycardia, dogs, swine, electrocardiography, ventricular fibrillation. 95 "Ventricular arrhythmias and local electrograms after chronic regional denervation of the ischemic are in the pig heart." J. Cinca, A. Bardaji, and A. Salas-Caudevilla. Journal of American College of Cardiology 14(1):225-232(1989). Descriptors: coronary artery occlusion, sympathectomy, ventricular fibrillation, electrocardiogram, animal model. 96 "Antiarrhythmic and antifibrillatory properties of McN-4130 in several animal models." B.P. Damiano, S.P. Sit, M.A. Fortunato, M.T. Stranieri, and M.D. Brannan. Journal of Cardiovascular Pharmacology 11(5):581-590(May 1988). Descriptors: anti-arrhythmia agents, indoles, anesthesia, blood pressure, drug effects, coronary disease, dogs, electrophysiology, heart rate, swine, ventricular fibrillation. 97 "Bretylium and diltiazem in porcine cardiac procedures." G.P. Rodgers, D.M. Cromeens, S.T. Minor and M.M. Swindle. Journal of Investigative Surgery 1(4):321-326(1988). Descriptors: pharmacology, ventricular fibrillation prevention and control, cardiovascular system surgery. 98 "Histoire naturelle de la regression de l'atherosclerose: Des medeles animaux a l'homme. [Natural history of the regression of atherosclerosis: From animal models to men.]" P. Hadjiisky, M.C. Bourdillon, and Y. Grosgogeat. Archives des Maladies du Coeur 81(11)1411-1417(November 1988). Descriptors: diet therapy, anthropoidea, pathology, dogs, pigeons, poultry, rabbits, rats, swine. 99 "Lipid burden in ischemic myocardium." A.J. Liedtke. Journal of Molecular and Cellular Cardiology 20(Suppl. 2):65-74(1988). Descriptors: oxfenicine, glycidic acid, heart muscle, lipid metabolism, amphophile fat droplet, carnitine acyltransferase, ultrastructure. 100 "Mechanism of decreased forward stroke volume in children and swine with ventricular septal defect and failure to thrive." W.J. Corin, M.M. Swindle, J.F. Spann, K. Nakano, M. Frankis, W.W.R. Biederman, A. Smith, A. Taylor, and B.A. Carabello. Journal of Clinical Investigation 82(2):544-551(1988). NAL call number: 448.8 J8295 Descriptors: heart output, heart stroke volume, heart output, body weight, age. 101 "Percutaneous, in vivo excimer laser angioplasty: Results in two experimental animal models." J.M. Isner, D. Gal, P.G. Steg, S.T. DeJesus, A.J. Rongione, K.R. Halaburka, G.A. Slovenkai, and R.H. Clarke. Lasers in Surgery and Medicine 8(3):223-232(1988). Descriptors: angioplasty, transluminal methods, arteriosclerosis, atherosclerosis, laser surgery, angiography, fiber optics, iliac artery, rabbits, silica, miniature swine. 102 "The spontaneously hypercholesterolemic pig as an animal model for human atherosclerosis." A.D. Attie and M.F. Prescott. I.L.A.R. News 30(4):5-12(Fall 1988). NAL call number: QL55.A1143. Descriptors: lipid, cholesterol, lipoprotein, histopathology. 103 "An animal model to examine the response to environmental stress as a factor in sudden cardiac death." G.W. Parker, L.H. Michael, and M.L. Entman. American Journal of Cardiology 60(18):9J-14J(December 28, 1987). NAL call number, RC681 A1A56 Descriptors: coronary disease, psychological stress, mortality, environment, frontal lobe physiology, hemodynamics, propranolol, swine, ventricular fibrillation. 104 "Coronary artery spasm: Definition, clinical characteristics, prognosis and experimental animal models." M. Nakamura. Nippon Naika Gakkai Zasshi 76(8):1171-1187(August 1987). Descriptors: coronary vasospasm, adverse effects of alcoholic beverages, angina pectoris, dogs, adverse effects of ergotamine, prognosis, swine, syncope. 105 "Endoscopic laser resection of atherosclerotic plaque in a live animal model. A preliminary report on some technical difficulties." P.F. Lawrence, J.M. Kercher, D.J. Dries, L. Peric-Golia, and J.A. Dixon. Journal of Vascular Surgery 6(5):470-475(November 1987). Descriptors: arteriosclerosis, atherosclerosis, adverse effects of laser surgery, catheterization, diet, swine, endoscopy. 106 "Endurance exercising miniature pigs: A review of methodology." A.H. Parsons, S.C. Smith, R. Kertzer, and I.A. Salkovitz. In: Swine in Biomedical Research M.E. Tumbleson (ed.), Vol. 1. Plenum Press, New York; 1986, pp. 143-151. NAL call number: RB125.C68 1985. Descriptors: treadmill, heart rate, electrocardiograph, tissue damage, heat stress, thermoregulation. 107 "Left ventricular dynamics in a controlled right heart bypass swine model." W.Y. Moores, T.A. Pfeffer, J.B. Wisniewski, W.Y. Heydorn, W.Y. Willford, D.C. Dembitsky and P.O. Daily. In: Swine in Biomedical Research M.E. Tumbleson (ed.), Vol. 1. Plenum Press, New York; 1986, pp. 341-349. NAL call number: RB125.C68 1985. Descriptors: transducer, ultrasonicmicrometer crystals, arterial venous shunt, pacemaker. 108 "The pig as a model for myocardial ischemia." F.C. White and C.M. Bloor. In: Swine in Biomedical Research M.E. Tumbleson (ed.), Vol. 1. Plenum Press, New York; 1986, pp. 481-490. NAL call number: RB125.C68 1985. Descriptors: left circumflex coronary artery, vessel occlusion, collateral circulation, treadmill, exercise, heart rate, ECG. 109 "A reproducible, quantitatable and rapidly reversible model of cardiogenic shock in swine." R.W. Bailey, A. Oshima, W.A. O'Roark and G.B. Bulkley. In: Swine in Biomedical Research M.E. Tumbleson (ed.), Vol. 1. Plenum Press, New York; 1986, pp. 363-372. NAL call number: RB125.C68 1985. Descriptors: heart output, ketamine, pentobarbital. 110 "Swine as animal models in cardiovascular research." K.T. Lee. In: Swine in Biomedical Research M.E. Tumbleson (ed.). Vol. 3. Plenum Press, New York; 1986, pp. 1481-1496. NAL call number: RB125.C68 1985. Descriptors: atherogenic diet, spontaneous atherosclerotic lesions, experimental atherosclerosis, histology, electrocardiogram. 111 Swine in Cardiovascular Research H.C. Stanton and H.J. Mersmann (eds.), Vol. 2. CRC Press: Boca Raton, FL; 1986, 177p. NAL call number: RC669.S87 v.2. Descriptors: nutrition and cardiovascular disease, atherosclerosis, arrhythmias, hypertension,intimal cell masses, effects of aspirin, effects of corn oil and butter, resting cardiovascular parameters, neuroendocrine control, hypoxia, in vitro porcine coronary artery, architecture, protein regulation, myocardial ischemia, blood flow, exercise. 112 Swine in Cardiovascular Research H.C. Stanton and H.J. Mersmann (eds.), Vol. 1. CRC Press: Boca Raton, FL; 1986, 169p. NAL call number: RC669.S87 v.1. Descriptors: evolution, breeds, behavior, husbandry, anatomy, restraint and handling, disease control, herd health, housing, anesthesia, physical exercise, stress, lipid metabolism, fatty acid metabolism, ischemia, heart mitochondria, gravitational stress, cardiovascular disease, spontaneous and experimental. 113 "Zur herz-kreislaufwirkung von Cordemcura on various animal models in vivo. [The cardiovascular effect of Cordemcura on various animal models in vivo.] E. Rhode, P. Muschick, D. Modersohn, H. Landmann, and H. Lowe. Pharmazie 41(3):194-195(March 1986). Descriptors: aminopyridines, cardiotonic agents, hemodynamics, drug effects on blood pressure, cardiac output, cats, dopamine, heart rate, rats, species specificity, swine, vascular resistance. 114 "Animal models in atherosclerosis research." M.P. Jokinen, T.B. Clarkson, and R.W. Prichard. Experimental and Molecular Pathology 42(1):1-28(February 1985). NAL call number: RB1 E9 Descriptors: arteriosclerosis, atherosclerosis, birds, dogs, muridae, primates, rabbits, swine. 115 "Animal models of coronary spasm and the pathophysiological events in regional vascular hypercontraction." H. Tomoike. Japanese Circulation Journal 49(1):101-107(January 1985). Descriptors: coronary vasospasm, smooth and vascular muscle, cimetidine, radiography, dogs, ergonovine, histamine, serotonin, miniature swine. 116 "Ventriculoatrial conduction in swine during cardiac pacing: animal model for retrograde conduction." T.A. Bowman and H.C. Hughes. The American Heart Journal 108(2):337-341(August 1984). Descriptors: tachycardia, electrocardiography, electrophysiology, atrium, ventricle, sinoatrial node. 117 "Atherosclerosis regression in animal models: Current concepts of cellular and biochemical mechanisms." R.W. St Clair. Progress in Cardiovascular Diseases 26(2):109-132(September/October 1983). Descriptors: arteriosclerosis, atherosclerosis, anthropoidea, aorta, birds, calcium metabolism, blood cholesterol, esters, dietary cholesterol, connective tissue, dogs, elastin metabolism, smooth and vascular muscle, rabbits, spontaneous remission, swine. 118 "Development of accelerated atherosclerosis. Concepts derived from cell biology and animal model studies." R.W. Mahley. Archives of Pathology and Laboratory Medicine 107(8):393-399(August 1983). Descriptors: arteriosclerosis, aorta cytology, apolipoproteins, cholesterol, dogs, fibroblasts, foam cells, lipoprotein, HDL, LDL, VLDL, macrophages, smooth muscle metabolism, rabbits, rats, receptors, endogenous substances, swine. 119 "Estimation of instantaneous blood flow through a rigid, coronary artery stenosis in anaesthetized domestic swine." Y. Sun, A.S. Most, W. Ohley, and H. Gerwirtz. Cardiovascular Research 17(8):499-504(August 1983). NAL call number: QM178 A1C38 Descriptors: circulation, adenosine, drug effects on blood pressure. 120 "Intravenous angiocardiography using digital image processing. II. Detection of left to right shunts in an animal model." H.G. Borgren, J.H. Bursch, R. Brennecke, and P.H. Heintzen. Investigative Radiology 18(1):11-17(January/February 1983). Descriptors: angiocardiography, ductus arteriosus, heart septal defects, radiography, computers, administration and dosage of diatrizoate, intravenous injections, swine, videotape recording. 121 "Investigations on neonatal cardiopulmonary reanimation using an animal model." E. Traub, W. Dick, P. Lotz, K.H. Lindner, and K. Engels. Journal of Perinatal Medicine 11(2):103-113(1983). Descriptors: newborn physiology, resuscitation, carbon dioxide, heart massage, oxygen, positive pressure respiration, artificial respiration, swine. 122 "Effect of intraaortic balloon counterpulsation on regional myocardial blood flow and oxygen consumption in the presence of coronary artery stenosis: Observations in an awake animal." H. Gewirtz, W. Ohley, D.O. Williams, Y. Sun, and A.S. Most. American Journal of Cardiology 50(4):829-837(October 1982). Descriptors: arterial occlusive diseases, assisted circulation, intra-aortic pumping, oxygen consumption, blood pressure, heart rate, myocardium metabolism, swine. ------------------------------------------------------------- HEMODYNAMICS/HEMATOLOGY 123 "Hemorrhage and hemorrhagic shock in swine: A review." J.P. Hannon. In: Swine as Models in Biomedical Research M.M. Swindle, D.C. Moody, and L.D. Phillips (eds.), Iowa State University Press, IA; 1992, pp. 197-245. NAL call number: RB125 S79 Descriptors: arterial pressure, Wiggers model, fixed-volume procedure, cardiac output, stroke volume, heart rate. 124 "Ratio of hepatic arterial-to-portal venous blood flow- validation of radionuclide techniques in an animal model." M.K. O'Connor, R.F. Krom, E.G Carton, L. Sanchez-Urdazpal, J.E. Juni, D.M. Ferguson, and R.F. Wiesner. Journal of Nuclear Medicine 33(2):239-245(1992). NAL call number: Rm845 J78 Descriptors: liver circulation, portal vein, imaging, technetium Tc 99m pentetate, diagnostic use. 125 "Coagulation factor IX, (human) affinity purified." C.P. Robinson. Drugs Today 27(5):299-303(1991). Descriptors: blood factor clotting 9, adverse drug reaction, drug purification, intravenous drug administration, hemophilia b, surgery, bleeding prevention, rabbit, swine, human, nonhuman. 126 "Goal directed therapy with dobutamine in a porcine model of septic shock: Effects on systemic and renal oxygen transport." G.A. Haywood, D. Tighe, R. Moss, N. Al-Saady, T.O.A. Foshola, S.P. Riley, I. Pearson, A. Webb, W.J. McKenna, and E.D. Bennett. Postgraduate Medical Journal 67(Suppl. 1):s36- s41(1991). Descriptors: kidney blood flow, oxygen transport, septic shock therapy, heart output, oxygen consumption, intravenous drug administration, dobutamine. 127 "Hypertonic fluid resuscitation improves cerebral oxygen delivery and reduces intracranial pressure after hemorrhagic shock." J.D. Schmoker, J. Zhuang, and S.R. Shackford. Journal of Trauma 31(12):1607-1613(1991). Descriptors: hypertonic solution, intracranial pressure, brain injury. 128 "Platelet activating factor is one of the mediators involved in endotoxic shock in pigs." R. Mozes, J.P.C. Jeiligers, C.J.A.M. Tak, F.J. Zijlstra, S. Ben-Efraim, P.R. Saxena, and I.L. Bonta. Journal of Lipid Mediators 4(3):309-325(1991). Descriptors: septic shock, hematology, female, escherichia coli endotoxin, thrombocyte activating factor, intravenous drug administration, ginkgolide b, microsphere ce 141, microsphere sn 113. 129 "External thoracic duct-venous shunt in conscious pigs for long term studies of connective tissue metabolites in lymph." L.T. Jensen, P. Olesen, J. Risteli, and I. Lorenzen. Laboratory Animal Science 40(6):620-624(1990). NAL call number: 410.9 P94 Descriptors: type I procollagen, type III procollagen, transport of connective tissue metabolites, hyaluronan. 130 "Hemodynamics and coronary blood flow during experimental aortic valvuloplasty comparison of the dual versus the single catheter methods." J.W. Moore, M.C. Slack, W.C. Kirby, and G.M. Graeber. American Heart Journal 119(1):136-142(1990). Descriptors: left ventricular occlusion, statistics. 131 "A quantitative study of some factors affecting the outcome of experimental epidural bleeding in swine." J.C. Ganz and N.N. Zwetnow. ACTA Neurochirurgica 102(3-4):164-172(1990). Descriptors: hematoma, intracranial pressure, electroencephalograph. 132 "On the hemodynamics of the pulmonary circulation of the mini pig after experimentally produced pulmonary embolism according to Sedlarik II. Influence of the hemodynamics of heart and circulation of thoracotomy." E. Ebner, T. Lesser, E. Reidel, and U. Zwiener. Zeitschrift fur Experimentelle Chirurgie, Transplantation, und Kunstliche Organe 22(6):347-350(1989). Descriptors: systolic and diastolic mean arterial blood pressure, pulmonary arterial pressure. 133 "On the hemodynamics of the pulmonary circulation of the mini pig after experimentally produced pulmonary embolism according to Sedlarik 1. The pulmonary embolism model according to Sedlarik in comparison with existing embolism models." T. Lesser, E. Ebner and U. Zwiener. Zeitschrift fur Experimentelle Chirurgie, Transplantation, und Kunstliche Organe 22(6):342-346(1989). Descriptors: pathophysiological mechanism. 134 "Resuscitation of conscious pigs following hemorrhage: Oxygen delivery and demand during fixed-volume hemorrhage and resuscitation with 7.5% NaCl in 6% dextran." J.P. Hannon, C.E. Wade, C.A. Bossone, M.M. Junt, and J.A. Loveday. Report No.: LIAR-369, Letterman Army Institute of Research, Presidio of San Francisco, CA. (January 1989). Descriptors: compensation, heart, hemoglobin, sodium chloride, hemorrhagic shock, oxygen output, ventilators. 135 "Effect of naloxone and ibuprofen on organ blood flow during endotoxic shock in pig." M.K. Nishijima, M.J. Breslow, C.F. Miller, and R.J. Traystman. American Journal of Physiology 255(1 Pt 2):H177-H184(1988). Descriptors: hemodynamics, thromboxane B-2, 6-ketoprostaglandin-F1-alpha, ibuprofen. 136 "Animal models to study the cardiopulmonary effects of artificial kidney membranes." A.K. Cheung. Blood Purification 5(2-3):155-161(1987). Descriptors: hemodialysis, hemodynamics, anaphylatoxins metabolism, arachidonic acid, cellulose analogs and derivatives, adverse effects of cellulose, complement activation, leukocytes, thromboxane metabolism, sheep, swine. 137 "Blood biochemical status of miniature swine during submaximal and exhaustive exercise." J.E. Wilderson, T.M. Sanders, and C.M. Bloor. Medicine and Science in Sports and Exercise 18(2):180-185(1986). Descriptors: catecholamine, lactate blood level, blood ph, protein blood level. 138 "The conscious pig as a large animal model for studies of hemorrhagic hypotension." J.P. Hannon and C.A. Bossone. In: Swine in Biomedical Research M.E. Tumbleson (ed.), Vol. 3. Plenum Press, New York; 1986, pp. 1413-1428. NAL call number: RB125.C68 1985. Descriptors: hypotension, hemorrhage, cannulae, arteries. 139 "Endotoxemic swine as a model for the metabolic response to sepsis." M.S. Hand, R.W. Phillips, M.J. Fettman, and L.G. Chandrasena. In: Swine in Biomedical Research M.E. Tumbleson (ed.), Vol. 1. Plenum Press, New York; 1986, pp. 453-460. NAL call number: RB125.C68 1985. Descriptors: gram negative bacteria, metabolic disorders, disease models, endotoxins. 140 "Hemodynamic characteristics of the conscious pig: A brief review." J.P. Hannon. In: Swine in Biomedical Research M.E. Tumbleson (ed.), Vol. 3. Plenum Press, New York; 1986, pp. 1341-1352. NAL call number: RB125.C68 1985. Descriptors: heart rate, cardiac and stroke index values, body weight, anesthesia, restraint, arterial, pulmonary and atrial pressure values, epinephrine, norepinephrine, vasopressin, renin activity, domestic and miniature swine. 141 "Hemodynamic and metabolic consequences of group B beta streptococcal sepsis in piglets." W.L. Meadow, P. Meus, B.F. Rudinsky, and E. Strates. In: Swine in Biomedical Research M.E. Tumbleson(ed.), Vol. 1. Plenum Press, New York; 1986, pp. 461-471. NAL call number: RB125.C68 1985. Descriptors: metabolic disorders, streptococcus, blood picture, heart output. 142 "Swine clinical chemistry." M.E. Tumbleson and D.A. Schmidt. In: Swine in Biomedical Research M.E. Tumbleson (ed.), Vol. 2. Plenum Press, New York; 1986, pp. 783-807. NAL call number: RB125.C68 1985. Descriptors: baseline hematologic values, serum magnesium, calcium, inorganic phosphorus, sodium, potassium, chloride, urea nitrogen, glucose, cholesterol, albumin, globulins, serum animo acids, blood sampling methods, factors affecting blood values, age, sex, time of fast, time of day, housing, stress. 143 "Swine hematology." D.A. Schmidt and M.E. Tumbleson. In: Swine in Biomedical Research M.E. Tumbleson (ed.), Vol. 2. Plenum Press, New York; 1986, pp. 767-782. NAL call number: RB125.C68 1985. Descriptors: erythrocyte, leukocyte, neutrophil and platelet counts, packed cell volumes, hemoglobin concentration, base line hematologic values, factors affecting blood values, sex, breed, age, laboratory. 144 "Coagulation factor-V and factor-VIII and ceruloplasmin constitute a family of structurally related proteins." W.R. Church, R.L. Jernigan, J. Toole, R.M. Hewick, J. Knopf, G.J. Knutson, M.E. Nesheim, K.G. Mann, and D.N. Fass. Proceedings of the National Academy of the United States of America 81(22):6934-6937(1984). Descriptors: bovine, porcine, human, evolutionarily linked proteins. 145 "Controlled endotoxinemia in pigs. A suitable model for in vivo studies of some hemodynamic, humoral and cellular reactions." O.K. Andersen, T. Lundgren, and A. Revhaug. Acta Chirurgica Scandinavica 150(8):599-606(1984). Descriptors: blood clotting disorder, blood cell count, septicemia. 146 "Learning from animal models of bleeding disorders." W.J. Dodds. Annals of the New York Academy of Sciences 406:59-61(1983). NAL call number: 500 N484 Descriptors: blood coagulation disorders, von Willebrand's disease, cat, dog, horse, swine diseases, hemophilia, thrombosis. 147 "An effective mass screening program for animal models of the inherited bleeding disorders." W.J. Dodds. Progress in Clinical and Biological Research 94:117-132(1982). NAL call number: RC627.8 I56 1981 Descriptors: blood coagulation disorders, von Willebrand's diseases, dog, cat, swine, cattle diseases, hemophilia. 148 "Joint report of the subcommittees on animal models of hemorrhagic and thrombotic diseases and on platelets." W.J. Dodds. Thrombosis and Haemostasis 48(1):106-107(August 24, 1982). Descriptors: blood coagulation disorders, diagnosis, bleeding time, platelet aggregation, dog, rat, swine. --------------------------------------------------------- PULMONARY SYSTEM 149 "Pulmonary function and hemodynamic effects of incremental positive end-expiratory pressure in ventilated piglets with normal lungs." T.G. Mundie, D. Easa, K.C. Finn, E.L. Stevens, G. Hashiro, and V. Balaraman. Clinical Research 41(1):95A(1993). Descriptors: abstract, pulmonary pediatrics, increased transmural pulmonary artery pressure, decreased stroke volume, decreased cardiac output model. 150 "Methodologies, devices, and new surgical concepts. Comparison of new iron chelating agents in the prevention of ischemia/reperfusion injury: A swine model of heart-lung transplantation." A.K Qayumi, W.R.E. Jamieson, A. Poostizadeh, E. Germann, and K.D. Gillespie. Journal of Investigative Surgery 5(2):115-127(1992). Descriptors: drug comparison, deferoxamine, 21 aminosteroid, tirilazad, drug efficacy, lung alveolus oxygen tension. 151 "Sequential CT in monitoring experimental lung transplant." P. Hammainen, L. Kivisaari, P. Aarnio, A. Lehtola, L. Heikkila, E. Taskinen, and A. Harjula. Journal of Computer Assisted Tomography 16(1):138-147(1992). Descriptors: ampicillin, ceftriaxone, methylprednisolone, cyclosporin, azathioprine, drug therapy, graft rejection, computer assisted tomography, swine, human, male, case report. 152 "On radiation induced pneumopathia." T. Herrmann and D. Schuh. Bildgebung Imaging 58(Suppl. 1):26-29(1991). Descriptors: thorax, radiotherapy, lung injury, histopathology, radiography, histopathology. 153 "Antiasthmatic effects of onions inhibition of 5 lipoxygenase and cyclooxygenase in vitro by thiosulfinates and cepaenes." H. Wagner, W. Dorsch, T. Bayer. W. Breu, and F. Willer. Prostaglandins, Leukotrienes and Essential Fatty Acids 39(1):59-62(1990). Descriptors: human, sheep, pig, model, bronchial asthma therapy, anti-inflammatory effect. 154 "Continuous arteriovenous hemofiltration CAVH therapy for sepsis induced acute lung injury in immature swine." J. Matson, P. Lee, F. Straughn, R. Pryor, and L. Hinshaw. The FASEB Journal 4(4):A953(1990). NAL call number: QH301.F3 Descriptors: staphylococcus aureus, model. 155 "Increased survival time after delayed histamine and prostaglandin blockade in a porcine model of severe sepsis induced lung damage." K. Byrne, T.D. Sielaff, B. Michna, P.D. Carey, C.R. Blocher, A. Vasquez, and H.J. Sugerman. Critical Care Medicine 18(3):303-308(1990). Descriptors: pseudomonas aeruginosa, cimetidine, diphenhydramine, ibuprofen, antiinflammatory drug, hypoxia, cardiovascular collapse, adult respiratory distress syndrome. 156 "Laser light scattering spectroscopy a new method to measure tracheobronchial mucociliary activity." K. Svartengren, L.G. Wiman, R. Thyberg, and R. Rigler. Thorax 44(7):539-547(1989). Descriptors: pig, ciliary beat frequency, in vitro and in vivo model. 157 "Right ventricular function during acute respiratory distress syndrome." C. Chartier, J.P. Haberer, and P.N. Dieng. Agressologie 30(1):39-42(1989). Descriptors: dog, human, monkey, sheep, pig, model, pulmonary circulation, positive expiratory pressure. 158 "A simplified method for autoregulation of blood flow in the extracorporeal membrane oxygenation circuit." J.B. Atkinson, P. Emerson, R. Wheaton, and C.M. Bowman. Journal of Pediatric Surgery 24(3):251-252(1989). Descriptors: newborn, blood flow, cavitation, air embolism, ventilation perfusion ratio. 159 "Sympathetic vascular control of the pig nasal mucosa III. Co- release of noradrenaline and neuropeptide Y." J.S. Lacroix, P. Stjarne, A. Anggard, and J.M. Lundberg. Acta Physiologica Scandinavica 135(1):17-28(1989). Descriptors: phenoxybenzamine, desipramine, pharmacological tool, norepinephrine, immunoreactivity, ATP, doppler flowmetry. 160 "Vagally mediated vasodilation by motor and sensory nerves in the tracheal and bronchial circulation of the pig." R. Matran, K. Alving, C.R. Martling, J.S. Lacroix, and J.M. Lundberg. Acta Physiologica Scandinavica 135(1):29-38(1989). NAL call number: QP1 A2 Descriptors: atropine, guanethidine, chlorisondamine, capasaicine. 161 "Mechanical properties of fetal minipig lungs after substitution of surfactant with fluorocarbon and dipalmitoylphosphatidyl-choline." J. Wuthe, W. Forster, P. Dangel, B. Widjaja, and R. Rufer. Research in Experimental Medicine 188(4):247-253(1988). Descriptors: fluorocarbon, lung surfactant, respiratory distress syndrome, fetus. 162 "Pulmonary exchange of solutes during experimental lung lavage in pigs." F.M. Juettner, J. Smolle, H. Popper, P. Rehak, W. Petek, and G. Friehs. Respiration 54(4):226-234(1988). Descriptors: serum concentration, fluid level exchange, half time permeability constants, protein, urea, creatine, respiratory disease therapy model. 163 "High-frequency ventilation: A study of the mechanisms of action." J.L. Theissen, P.P. Lunkengeimer, F.J. Mersch, G. Frieling, K. Redmann, and P. Lawin. Annales Francaises d'Snesthesie it de Reanimation 7(3):233-238(1987). Descriptors: intrapulmonary pressure, carbon dioxide, diffusion, endobronchial aerodynamics. 164 "Lung reflexed affecting the larynx in the pig, and the effect of pulmonary microembolism." G. Aguggini, M.G. Clement, and J.G. Widdicombe. Quarterly Journal of Experimental Physiology 72(1):95-104(1987). NAL call number: 447.8 Q1 Descriptors: phenylbiguanide, capsaicin, apnea, blood pressure, cardiac rhythm, animal experiments, airflow resistance, pulmonary embolism. 165 "Tracheomalacia: An experimental animal model for a new surgical approach." I. Vinograd, R.M. Filler, S.J. England, C. Smith, D. Poenaru, A. Bahoric, and G. Kent. The Journal of Surgical Research 42(6):597-604(June 1987). Descriptors: cartilage diseases, transplantation of periosteum, tracheal diseases, airway resistance, cough, swine, tibia. 166 "Development of a pneumonia model in pigs using pseudorabies virus and Pasteurella multocida." C. Pijoan, M. Fuentes, and E. Noyes. In: Swine in Biomedical Research M.E. Tumbleson (ed.), Vol. 1. Plenum Press, New York; 1986, pp. 491-498. NAL call number: RB125.C68 1985. Descriptors: pasteurella multocida, aujeszky virus. 167 "Effect of reduced ventilation on pneumonia in young pigs." E.P. Noyes, L.D. Jacobson, C. Pijoan, and J.J. Boedicker. In: Swine in Biomedical Research M.E. Tumbleson (ed.), Vol. 1. Plenum Press, New York; 1986, pp. 209-216. NAL call number: RB125.C68 1985. Descriptors: bacteria, isolation, weight gain, feed conversion. 168 "Fractionated lung irradiation in young pigs with 6.2 MEV neutrons and cobalt-60." L. Voigtmann, A. Knorr, J. Lorenz, U. Johannsen, and K. Welker. Radiotherapy and Oncology 7(1):69-76(1986). Descriptors: pneumopathy, hydroxyproline, effective dose, cancer, radiotherapy. 169 "Host specific lung bacterial clearance and acute respiratory failure." S.M. Steinberg, S.H. Crocker, B.D. Lowery, and C.T. Cloutier. In: Swine in Biomedical Research M.E. Tumbleson (ed.), Vol. 1. Plenum Press, New York; 1986, pp. 499-505. NAL call number: RB125.C68 1985. Descriptors: dogs, pigs, pseudomonas aeruginosa, sepsis, respiratory disease. 170 "The pig as a respiratory model for man." M.C. Clement and G. Aguggini. Scienza Veterinaria e Biologia Animale (No.3):33-36(1986). Descriptors: animal models of human disease, respiratory system, anatomy. 171 "Technique of right lymphatic duct cannulation for pulmonary lymph collection in an acute porcine model." G.J. Chuang, C.X. Gao, D.S. Mulder, and R.C. Chiu. The Journal of Surgical Research 41(6):563-568(December 1986). Descriptors: catheterization methods, lung anatomy and histology, specimen handling, blood protein analysis. 172 "Physiological activity of pulmonary surfactant with low protein content: Effect of enrichment with synthetic phospholipids." P. Berggren, T. Curstedt, and G. Grossman. Experimental Lung Research 8(1):29-51(1985). Descriptors: hyaline membrane disease, lung compliance, dipalmitoyllecithin, drug screening, respiratory distress syndrome, prematurity. 173 "Pulmonary trapping of platelets and fibrin after musculoskeletal trauma: An experimental model." I. Jansson, L. Loven, L. Rammer, and S. Lennquist. Journal of Trauma 25(4):288-298(1985). Descriptors: locomotor disease, lung embolism, thrombocyte, fibrin, adult respiratory distress syndrome, radioactivity. GASTROINTESTINAL FUNCTION 174 "Pathogenicity and antigen detection of the Nouzilly strain of transmissible gastroenteritis coronavirus, in 1-week-old piglets." M.J. Cubero, S. Bernard, L. Leon, P. Berthon, and A. Contreras. Journal of Comparative Pathology 106(1):61-72(1992). NAL call number: 41.8 J82 Descriptors: immunohistochemistry, intestine, virogenesis, tissue distribution. 175 "Advantages of a narrow-range, medium molecular weight hydroxyethyl starch for volume maintenance in a porcine model of fecal peritonitis." A.R. Webb, D. Tighe, R.F. Moss, N. Al- Saady, J.W. Hynd, and E.D. Bennett. Critical Care Medicine 19(3):409-416(1991). Descriptors: hetastarch, adult respiratory distress syndrome. 176 "A comparison of portal versus systemic venous drainage in the pig small-bowel allograft recipient." H. Kaneko, M.A. Fischman, T.M. Buckley, and R.T. Schweizer. Surgery 109(5):663-670(1991). Descriptors: small intestine, transplantation, portal vein flow. 177 "Gastritis associated with infection by Helicobacter pylori: Comparative pathology in humans and swine." T.A. Bertram, S. Krakowka, and D.R. Morgan. Reviews of Infectious Diseases 13(Suppl. 8):s714-s722(1991). Descriptors: bacterial infection, stomach mucosa, endoscopy. 178 "Necrotizing enterocolitis in a neonatal piglet model." I.T. Cohen, S.D. Nelson, R.A. Moxley, M.P. Hirsh, T.C. Counihan, and R.F. Martin. Journal of Pediatric Surgery 26(5):598-601(1991). Descriptors: autopsy, histology, newborn. 179 "Antisecretory and antiiflammatory properties of bismuth subsalicylate." C.D. Ericsson, C. Tannenbaum, and T.T. Charles. Reviews of Infectious Diseases 12(Suppl. 1):S16- S20(1990). NAL call number: RC111 R4 Descriptors: escherichia coli, vibrio cholerae, rabbit, pig, rat, pepto bismol, antibacterial drug, drug, inflammatory diarrhea. 180 "Effect of different fractions of alkaline reflux on the gastric stump and the esophagus an experimental research on pigs." G. Clemente, R. Manni, F.M. Vecchio, S. Rizzo, S. Furgiuele, P. Perrotti, and F. Crucitti. The Journal of Surgical Research 48(2):121-126(1990). Descriptors: bile secretion, pancreaticoduodenal secretion, gastroesophageal reflux, gastritis, histopathology. 181 "Experimental studies on the healing of colonic anastomoses." M.J. Koruda and R. H. Rolandelli. Journal of Surgical Research 48(5):504-516(1990). Descriptors: rat, rabbit, dog, pig, models, nutrition, antineoplastic therapy, radiation, chemotherapy. 182 "Hepatotoxicity of the colon carcinogen azoxymethane in the Hanford Moore miniature swine." M.J. Wargovich, W. Satterfield, R. Price, L.C. Stephens, L. Coghlan and B. Levin. Gastroenterology 98(5 Part 2):A318(1990). NAL call number: RC799 G37 Descriptors: model, endoscopy, colon cancer, hepatic necrosis. 183 "Inoculation of barrier born pigs with helicobacter pylori: A useful animal model for gastritis type B." L. Engstrand, S. Gustavsson, A. Jorgensen, A. Schwan, and A. Scheynius. Infection and Immunity 58(6):1763-1768(June 1990). NAL call number: QR1 I57 Descriptors: bacteria, gastritis, inoculation. 184 "Jejunum is preferential for the construction of a bianchi segment in short bowel syndrome." W.D. Buie, O.G. Thurston, A.B.R. Thomson, and R.N. Fedorak. Gastroenterology 98(5 Part 2):A162(1990). NAL call number: RC799 G37 Descriptors: pig, model, bowel lengthening method, glucose transport. 185 "Plasma levels of vasoactive intestinal peptide VIP at birth in swine." G. Condemi, B.W. Hundley, M. Blank, A.C. Yao, F.T. Velcek, H.L. Cohen, and P.M. Gootman. Pediatric Research 27(4 Part 2):41A(1990). Descriptors: postnatal development. 186 "Complete occlusion of the intestinal tract with staples an experimental study and a case report." Y.T.M. Lee, J.A. Ameika, R.R. Martin, and W.S. Stokes. Digest of Surgery 6(4):185-190(1989). Descriptors: pig model of human knife wounds, bleeding, necrotic giant ulcer, duodenum, proximal jejunum, pancreatic fistula, distal ileum, colon, clinical application. 187 "Establishment of Campylobacter Pylori CP in barrier born pigs an animal model for CP related human diseases." L. Engstrand, A. Jorgensen, A. Schwan, and S. Gustavsson. Scandinavian Journal of Gastroenterology Supplement 159(24):39(1989). NAL call number: RC799 S33 Suppl. Descriptors: gastritis, antibody response. 188 "Experimental models in vivo for Campylobacter Pylori." B.J. Marshall. Gasteroenterologische Clininque et Biologique 13(Suppl.1):50B-52B(1989). Descriptors: human, pig, macaca mulatta, macaca fascicularis, macaca nemestrina, gastritis. 189 "Gangliosides are novel gastroprotective and antiulcer agents." S. Szabo, S. Dipietro, R.E. Morales, I.T. Lippe, and C. Rogers. Gastroenterology 96(5 Part 2):498(1989). NAL call number: RC799 G37 Descriptors: rat, porcine, omentum extract, bovine brain gangliosides, antiulcer agent, ethanol, hydrochloric acid, aspirin, chemically induced gastritis, mucosal lesion, ischemic erosion, chronic duodenal ulcer. 190 "Investigations of solutions with a different content of BCAA to the protein metabolism in the postoperative periods 1. Report nitrogen 15 tracer kinetic metabolic animal model to study the influence of parenteral amino acid supply on the nitrogen metabolism." R. Matkowitz, W. Hartig, R. Ritter, and H. Betzler. Infusionstherapie 16(3):125-131(1989). Descriptors: pig, human implications, metabolic drug, branched chain amino acid, parenteral nutrition. 191 "A large animal model (swine) to study the diagnosis and treatment of cholelithiasis." S.L. Griffith, B.T. Burney, F.J. Fry, and T.D. Franklin Jr. Investigative Radiology 24(2):110-114(February 1989). Descriptors: bile acid and salts analysis, diagnosis and therapy, cholesterol. 192 "A modified thomas cannula for duodenal cannulation in pigs." B.R. Landers, P.G. Devitt, and G.G. Jamieson. Australian Veterinary Journal 66(6):182-183(1989). NAL call number: 41.8 Au72 Descriptors: motility, large animal model. 193 "Acetaminophen induced acute hepatic failure in pigs: Controversial results to other animal models." D. Henne-Bruns, J. Artwohl, C. Broelsch, and B. Kremer. Research in Experimental Medicine (Berlin) 188(6):463-472(1988). Descriptors: acetaminophen toxicity, liver diseases, acetaminophen administration and dosage, anesthesia, dose response relationship, methemoglobin. 194 "The miniature pig as an animal model for the study of intestinal enzyme development." R.J. Shulman, S.J. Henning, and B.L. Nichols. Pediatric Research 23(3):311-315(March 1988). NAL call number: RJ1.P4 Descriptors: enzyme activity, development, intestinal mucosa. 195 "A technique to study splanchnic metabolism in the unrestrained conscious pig." C.L. Van Berlo, A.E. Van den Bogaard, M.C. Bost, and P.B. Soeters. Laboratory Animal Science 38(4):463-466(August 1988). NAL call number: 410.9 P94 Descriptors: blood specimen collection, indwelling aorta catheters, intestinal blood supply, portal vein, restraint. 196 "Zur pathogenese des Morbus Chrohn. Bewertungskriterien fur ein tierexperimentelles modell." [Pathogenesis of Chrohn's disease. Evaluation criteria for an animal model.] E. Nagel, E. Guthy, S. Schattenfroh, J. Pohlenz, and R. Pichlmayr. Schweizerische Medizinische Wochenschrift 118(20):766-769(May 21, 1988). NAL call number: R51 S35 Descriptors: dietary fat metabolism, swine, intestinal mucosa pathology. 197 "Absence of beneficial effects of clonidine treatment in a piglet diarrhoea model." V. Cools, E. Cox, and A. Houvenaghel. Medical Science Research 15(20):1263-1264(1987). Descriptors: clonidine, adverse drug reaction, side effects, heart rate, blood pressure. 198 "Characterization of the Yucatan miniature pig skin and small intestine for pharmaceutical applications." T. Kurihara- Bergstrom, M. Woodworth, S. Feisullin, and P. Beall. Laboratory Animal Science 36(4):396-399(1986). Descriptors: gastrointestinal tract, caffeine metabolism, anatomy, histology, human organ system model. 199 "Comparative physiology of the mammalian colon and suggestions for animal model of human disorders." C.E. Stevens, R.A. Argenzio, and M.C. Roberts. Clinical Gastroenterology (England) 15(4):763-785(October 1986). Descriptors: swine, colonic pathology. 200 "Peptic ulceration--what can be expected from animal models." R.A. Hinder. Scandinavian Journal of Gastroenterology Supplement 125:195-202(1986). NAL call number: RC799 S33 Suppl. Descriptors: duodenal ulcer, papio, stomach ulcer, physiopathology, therapy, dogs, swine, species specificity. 201 "The pig in studies of diarrhea pathophysiology." R.A. Argenzio. In: Swine in Biomedical Research M.E. Tumbleson (ed.), Vol. 1. Plenum Press, New York; 1986, pp. 441-452. NAL call number: RB125.C68 1985. Descriptors: swine dysentery, transmissible gastroenteritis virus, treponema hyodysenteriae, therapy. 202 "Using the pig to study digestion and fermentation in the gut." S.E. Fleming and D. Arce. In: Swine in Biomedical Research M.E. Tumbleson (ed.), Vol. 1. Plenum Press, New York; 1986, pp. 123-142. NAL call number: RB125.C68 1985. Descriptors: fiber, volatile fatty acids. 203 "Pathophysiology of swine dysentery." R.A. Argenzio. In: Animal Models For Intestinal Disease (ed.) C.J. Pfeiffer. CRC Press, Baco Raton, FL; 1985, pp. 3-19. NAL call number: RC860 A55 Descriptors: swine diseases, bacterial diseases, treponema hyodysenteriae, intestinal diseases, pathogenesis, human disease models, colon, absorption. 204 "Necrotizing enterocolitis: A review of animal models." S.L. Topalian and M.M. Ziegler. The Journal of Surgical Research 37(4):320-336 (October 1984). Descriptors: newborn physiology, newborn diseases, asphyxia neonatorum, bacteria physiology, blood volume, breast feeding, adverse effects of catheterization, dogs, enteral feeding, chemically induced enterocolitis, exchange transfusion, whole blood, formulated food, goats, hypertonic solutions, hypothermia, indomethacin, intestinal mucosa, necrosis, rats, swine, umbilical arteries. ------------------------------------------------------------- LIVER AND PANCREAS 205 "Effect of nutritional status on organic anion clearance by the swine liver." K.A. Kudsk, D.F. Kisor, B. Waters, J.M. Mirtallo, A.J. Campbell III, and R.A. Wooding-Scott. Surgery 111(2):188-194(1992). Descriptors: liver dysfunction, malnutrition, liver clearance. 206 "Orthotopic liver transplantation in outbred and partially inbred swine." M.W. Flye. In: Swine as Models in Biomedical Research M.M. Swindle, D.C. Moody, and L.D. Phillips (eds.), Iowa State University Press, IA; 1992, pp. 44-56. NAL call number: RB125 S79 Descriptors: liver homografts, liver biopsies, Large White, Wessex, Landrace. 207 "Simultaneous en-bloc allotransplantation of pancreas and kidney in a large animal-model -- Comparison of en-bloc vs separate pancreas and kidney-transplantation in the pig." R. Grussner and D. Sutherland. Zentralblatt Fur Chirurgie 117(11):607-615(1992). Descriptors: pancreas-kidney transplantation, cystoscopic transduodenal biopsy, duodenocystostomy. 208 "Swine as a model for pancreatic beta-cell transplantation." Y. Mullen, Y. Taura, M. Nagata, K. Miyazawa, and E. Stein. In: Swine as Models for Biomedical Research M.M. Swindle, D.C. Moody, and L.D. Phillips (eds.), Iowa State University Press, IA; 1992, pp. 16-34. NAL call number: RB125 S79 1992 Descriptors: diabetes mellitus, fetal porcine islets, drug induced diabetes, streptozotocin. 209 "In-situ protection of the liver with the HTK solution of bretschneider." P. Lamesch, S. Raygrotzki, G. Kehrer, G. Gubernatis, B. Ringe, B. Evers, E.A. Yacoub, and R. Pichlamayr. Langenbecks Archiv fuer Chirurgie 376(2):85-92(1991). Descriptors: ischemia, transaminase, hepatic blood flow, histidine buffered tryptophan ketoglutarate solution. 210 "Islet xenotransplantationin a pre-clinical large animal model." P. Morel, D.B. Kaufman, J.Platt, K. Braymann, M.J. Field, J.K. Lloveras, P.S. Almond, C. Fasola, P. Kyriakides, and P. Tzardis. Transplantation Proceedings 23(1 Part 1):875-876(February 1991). Descriptors: islets of langerhans, blood glucose metabolism, diabetes mellitus, experimental surgery, immunosuppression, pancreatectomy, dogs, swine. 211 "A new surgical model of acute liver failure in the pig: Experimental procedure and analysis of liver injury." F. Filipponi, L.P. Fabbri, M. Marsili, F. Falcini, C. Benassai, M. Nucera, and P. Romagnoli. European Surgical Research 23(1):58-64(1991). Descriptors: hepatic coma, liver failure, liver resection, portocaval shunt, experimental surgery, female. 212 "Rapid liver metabolism, urinary and biliary excretion, and enterohepatic circulation of 16alpha-radioiodo-17beta- estradiol." A. Scharl, M.W. Beckmann, J.E. Artwohl, S. Kullander, and J.A. Holt. International Journal of Radiation, Oncology, Biology, Physics 21(5):1235-1240(1991). Descriptors: estradiol, iodine 123, pharmacology, pharmacokinetics, enterohepatic circulation. 213 "Six-hour porcine liver storage without flushing or perfusion." B.H. Peinaar, G.N. Stapleton, M. Bracher, Z. Lotz, C.R. Innes, J. Fourie, and R. Hickman. Transplantation 52(1):38-43(1991). NAL call number: QP89 T73 Descriptors: liver transplantation, adenosine triphosphate, cardioplegic agent, euro collins solution. 214 "Experimental gallstone dissolution with methyl tert butyl ether MTBE and transcutaneous ultrasound energy." S.L. Griffith, B.T. Burney, F.J. Fry and T.D. Franklin. Investigative Radiology 25(2):146-152(1990). Descriptors: drug, enzymes, hepatocellular injury, gallbladder ablation. 215 "Extracorporeal shock wave lithotripsy of experimental gallstones in pigs." R. Capdeville, J. Andre-Bougaran, F. Barrat, and J. Moreaux. Gastroenterology and Clinical Biology 14(2):120-123(1990). Descriptors: firing frequency, fragmentation. 216 "Hepatic selenium concentration in pigs with microangiopathy (mulberry heart disease): An animal model for the study of oxidative damage." H. Korpela. International Journal of Vitamin and Nutrition Research 60(2):156-158(1990). NAL call number: 389.8 Z33 Descriptors: selenium deficiency, liver. 217 "A method for the massive separation of highly purified adult porcine islets of langerhans." R. Calafiore, F. Calcinaro, G. Basta, M. Pietropaolo, A. Falorni, M. Piermattei, and T.I.P. Brunet. Metabolism, Clinical and Experimental 39(2):175-181(1990). NAL call number: 448.8 M56 Descriptors: model, xenotransplant, diabetes mellitus hyperglycemia, immunoprotection. 218 "Prostanoid release in experimental liver transplantation." S. Post, M. Goerig, G. Otto, M. Manner, N. Senninger, B. Kommerell, and C. Herfarth. Transplantation 49(3):490-494(1990). Descriptors: pig, prostaglandin E2 6, ketoprostaglandin F1 alpha, thromboxane B2, inflammation, cardiovascular alteration. 219 "Protease inhibitor gabexate mesilate in experimentally induced acute pancreatitis with early gram negative infection in goettigen mini pigs therapeutic efficiency and influence on hemostasis and fibrinolysis." J. Heitz, B. Semsch, C. Emde, U. Jansen, and J.H. Schaefer. Zeitschrift fur Gastroenterologie 28(4):192-197(1990). Descriptors: escherichia coli, enzyme inhibitor, metabolic and drugs, necrotizing pancreatitis. 220 "Animal models of pancreatic transplant." [Modeles animaux de transplantation pancreatique.] J.J. Duron, P. Imbaud, D. Dutet, J. Duhault, D. Ravel, L. Oliver, and M. Dubois. Journ'ees Annuelles de Diabetologie L'Hotel Dieu 115-124(1989). Descriptors: dogs, swine, primates, review, tutorial, blood supply, secretions, autologous and homologous transplantation. 221 "Disturbances of reticuloendothelial function following experimental liver transplantation." G. Lahnborg, M. Bracher, R. Hickman, and J. Terblanche. European Surgical Research 21(3-4):129-136(1989). Descriptors: carbon clearance, preservation fluid, pig, model. 222 "The effect of venovenous bypass on portal vein bacteremia in orthotopic liver transplantation." C. Christophi, B. Morgan, R. Wale, and I. Mcinnes. Transplantation Proceedings 21(5):3859-3860(1989). Descriptors: pig, anhepatic phase, portal circulation occlusion, immunosuppressed host, sepsis, model, mortality rate, morbidity rate. 223 "Experimental chronic pancreatis in the pig." P. Pitkaranta, L. Kivisaari, S. Nordling, A. Saari, and T. Schroder. Scandinavian Journal of Gastroenterology 24(8):987-992(1989). NAL call number: RC799 S33 Descriptors: interstitial fibrosis, chronic inflammation, diarrhea. 224 "Magnetic resonance imaging in detecting acute oedematous and hemorrhagic pancreatitis: An experimental study in pigs." P. Puolakkaienen, L. Kivisaari, J. Sipponen, C.G. Standertskjold- Nordenstam, P. Nuutinen, and T. Schroder. European Surgical Research 21(1):25-33(1989). Descriptors: nuclear magnetic resonance imaging, computer assisted tomography, edema, bleeding, histology. 225 "Neodymium YAG laser and ethanol ablation of hepatic tissue an animal model for treatment of hepatic metastasis." A.H. Dachman, J.A. McGehee, T.E. Beam, and J.A. Burris. Lasers in Surgery and Medicine 0(Suppl. 1):23(1989). Descriptors: pig, sonography, yttrium, aluminum, garnet. 226 "No improvement of pancreas transplant endocrine function by exogenous insulin infusion islet rest in the postoperative period." D.C. Dafoe, D.A. Campbell Jr., L. Rosenberg, R.M. Merion, I. Ucros, A.I. Vinik, H. Klandorf, and J.G. Turcotte. Transplantation 48(1):22-26(1989). NAL call number: QP89 T73 Descriptors: pig, C peptide, glucose tolerance, model, microanatomical similarity. 227 "Pyridine nucleotide fluorometry in preserved porcine liver with fluorocarbon emulsion." N. Ozaki, Y. Tokunaga, I. Ikai, M. Zaima, Y. Sakai, Y. Shimahara, Y. Kamiyama, Y. Yamaoka, K. Ozawa, and Y. Nakase. Transplantation 48(2):198-201(1989). NAL call number: QP89 T73 Descriptors: total adenine nucleotide concentration, energy charge, tissue ketone body ratio, oxidation reduction changes, liver allograft, survival, clinical applications. 228 "An animal model for radiologic biliary interventional procedures." C.D. Becker and H.J. Burhenne. Investigative Radiology 23(1):30-32(January 1988). Descriptors: cholangiography, cholecystography, cholecystostomy methods, swine. 229 "Dissolution of gallstones using methyl tertiary butyl ether in an animal model." J.P. McGahan, H. Tesluk, J.M. Brock, R. Johnston, and D.B. Shaul. Investigative Radiology 23(8):599-603(August 1988). Descriptors: drug therapy, cholelithiasis, therapeutic use of ethers, disease model, swine. 230 "Pancreatectomized swine as a model of diabetes mellitus." K.C. Stump, M.M. Swindle, C.D. Saudek, and J.D. Strandberg. Laboratory Animal Science 38(4):439-443(1988). Descriptors: infections, hypoglycemia, bacteria, experimental diabetes mellitus, pancreatectomy. 231 "Aprotinin and Nasub 2CaEDTA in experimental hemorrhagic pancreatitis in pigs." P. Puolakkainen, A. Paananen, and M. Kaarne. Scandinavian Journal of Gastroenterology 22(1):35-41(1987). Descriptors: drug efficacy, drug toxicity, chemically induced pancreatitis, aprotinin pharmacology. 232 "The elimination of trypsin-alpha-macroglobulin complexes from the blood circulation in pigs during acute pancreatitis and after massive intravenous trypsin infusion." B. Sjolund, A. Lasson, and K. Ohlsson. Scandinavian Journal of Clinical and Laboratory Investigation 47(2):131-141(1987). Descriptors: trypsin, proteinase inhibitor, infusion, alpha 2 macroglobulin. 233 "The pig as an animal model for the study of nitrosamine metabolism." G.W. Harrington, P.N. Magee, H.M. Pylypiw Jr., R.F. Bevill, D.R. Nelson and J.C. Thurmon. IARC Scientific Publications (84):132-134(1987). NAL call number: RC261 A1I5 Descriptors: bile metabolism, dimethylnitrosamine, liver blood supply, portal vein, reference values. 234 "Effects of age on hepatic drug metabolism in miniature swine." J.O. Peggins, L.A. Shipley, and M. Weiner. In: Swine in Biomedical Research M.E. Tumbleson (ed.), Vol. 1. Plenum Press, New York; 1986, pp. 39-48. NAL call number: RB125.C68 1985. Descriptors: liver, pharmokinetics, aniline hydroxylase, p- chloro-N-methylaniline, demethylase, UDP- glucuronyltransferase, cytochrome P-450, Hormel-Hanford miniature swine. 235 "Induction and management of diabetes mellitus in the pig." J.D. Wilson, D.P. Dhall, C.J. Simeonovic, and K.J. Lafferty. Australian Journal of Experimental Biology and Medical Science 64(6):489-500(1987). Descriptors: streptozotocin, pharmacologic tool, pancreatectomy, pancreatic islet transplant. 236 "Studies of gestational diabetes using the pig as a model." D.B. Hausman, T.R. Kasser, R.W. Seerley and R.J. Martin. In: Swine in Biomedical Research (ed.) M.E. Tumbleson. Vol. 1. Plenum Press, New York. 1986. pp. 561-572. NAL call number: RB125.C68 1985. Descriptors: pregnancy, food consumption, glucose tolerance, lipid metabolism. 237 "A successful technique of in vivo isolated liver perfusion in pigs." C.J.H. Vand De Velde, B.J.L. Kothius, and H.W.M. Barenbrug. Journal of Surgical Research 41(6):593-599(1986). Descriptors: cancer chemotherapy, fluorouracil, cytostatic agent. 238 "Ultrasound monitored hepatic cryosurgery: Longevity study on an animal model." J.C. Gilbert, G.M. Onik, W.K. Hoddick. B. Rubinsky, and L.D. Ferrell. Cryobiology 23(3):277-285(June 1986). Descriptors: cryosurgery methods, liver surgery, ultrasonic diagnosis, necrosis, disease models, dogs, swine. 239 "Ultrastructure of the piglet liver." A. Singh and E. Shahidi. In: Swine in Biomedical Research M.E. Tumbleson (ed.), Vol. 1. Plenum Press, New York; 1986, pp. 77-87. NAL call number: RB125.C68 1985. Descriptors: liver cells, cell ultrastructure, hepatocytes, marginal plate, oligociliated cell function, micrographs, perinatal biology, Yorkshire piglets. ------------------------------------------------------------ NUTRITION 240 "Effect of nutritional status on organic anion clearance by the swine liver." K.A. Kudsk, D.F. Kisor, B. Waters, J.M. Mirtallo, A.J. Campbell III, and R.A. Wooding-Scott. Surgery 111(2):188-194(1992). Descriptors: liver dysfunction, malnutrition, liver clearance. 241 "Effects of lactulose and lactitol on protein digestion and metabolism in conventional and germ free animal models: Relevance of the results to their use in the treatment of portosystemic encephalopathy." S.P. Bird, D. Hewitt, B. Ratcliffe, and M.I. Gurr. Gut: Journal of the British Society of Gastroenterology 31(12):1403-1406(1990). NAL call number: RC799 G8 Descriptors: digestion, drug effects, hepatic encephalopathy, sugar alcohols, diet therapy, urine nitrogen, miniature swine, inbred strains of rats. 242 "Low selenium and infant health in Christchurch." B.A Dolamore, K.B. Sluis, J.C. McGrouther, S. Grant, B.A. Darlow, and C.C. Winterbourn. Proceedings of the Nutrition Society of New Zealand 15:181-186(1990). Descriptors: infants, nutritional state, cot death, peroxidation. 243 "The nutritional regulation of growth hormone action." J.M. Pell and P.C. Bates. Nutrition Research Reviews 3(0):163-192(1990). NAL call number: QP141 A1N87 Descriptors: human, pig, muscle, connective tissue, adipose tissue. 244 "Food-induced histaminosis under diamine oxidase (DAO) blockade in pigs: Further evidence of the key role of elevated plasma histamine levels as demonstrated by successful prophylaxis with antihistamines." J. Sattler, W. Lorenz, K. Kubo, A. Schmal, S. Sauer, and L. Luben. Agents and Actions 27(1-2):212-214(1989). NAL call number: RS122 A3 Descriptors: dimetidene, cimetidine, aminoguanidine, hypotension. 245 "Investigations of solutions with a different content of BCAA to the protein metabolism in the postoperative periods 1. Report nitrogen-15 tracer kinetic metabolic animal model to study the influence of parenteral amino acid supply on the nitrogen metabolism." R. Matkowitz, W. Hartig, R. Ritter, and H. Betzler. Infusionstherapie 16(3):125-131(1989). Descriptors: branched chain amino acid, human implications, perenteral nutrition. 246 "Organ changes in pigs after longterm parenteral nutrition." K. Nordstrand, T.J. Eide, S.M. Almdahl, O. Rokke, and E. Gierscksky. Clinical Nutrition 8(1):29-34(1989). Descriptors: spleen, liver, epithelioid cell, pulmonary artery inflammation, macrophage stimulation. 247 "Vitamin Dsub 3 metabolism in a pig strain with pseudo vitamin D-deficiency rickets, type I." R. Kaune and J. Harmeyer. Acta Endocrinologica 115(3):345-352(1987). Descriptors: drug efficacy, colecalciferol, calcitriol, 24,25 dihydroxyocolecalciferol. 248 "Absence of renal 25-hydroxycholecalciferol-1-hydroxylase activity in a pig strain with vitamin D-dependent rickets." I. Winkler, F. Schreiner, and J. Harmeyer. Calcified Tissue International 38(2):87-94(1986). Descriptors: kidney cortex, 25 hydroxycolecalciferol 1 monooxygenase. 249 "Amino acid metabolism in swine: Applicability to normal and altered amino acid metabolism in humans." N.J. Benevenga. In: Swine in Biomedical Research M.E. Tumbleson (ed.), Vol. 2. Plenum Press, New York; 1986, pp. 1017-1030. NAL call number: RB125.C68 1985. Descriptors: crude protein, homocystinuria, sulfur amino acids, methionine, tyrosine and monosodium glutamate metabolism. 250 "Life cycle feeding: Maternal nutrition and progeny development." W.G. Pond. In: Swine in Biomedical Research M.E. Tumbleson (ed.), Vol. 2. Plenum Press, New York; 1986, pp. 915-930. NAL call number: RB125.C68 1985. Descriptors: nutritional requirements for normal reproduction and lactation, postnatal growth, digestible energy, metabolizable energy, crude protein, essential amino acids, human fetal brain development, postnatal learning. 251 "The pig as a model for aberrations associated with carbohydrate and lipid metabolism." H.J. Mersmann. In: Swine in Biomedical Research M.E. Tumbleson (ed.), Vol. 2. Plenum Press, New York; 1986, pp. 981-995. NAL call number: RB125.C68 1985. Descriptors: carbohydrate metabolism, diabetes, hypoglycemia, dietary fiber, lipid metabolism, anabolism, liver, fatty acids, catabolism, lipolysis. 252 "A piglet model for infant total parenteral nutrition studies." R.M. Goldstein, T. Hebiguchi, G.D. Luk, T. Fazi, T.R. Guilarte, F.A. Franklin, P.W. Niemiec and D.L. Dudgeon. In: Swine in Biomedical Research M.E. Tumbleson (ed.), Vol. 2. Plenum Press, New York; 1986, pp. 1137-1145. NAL call number: RB125.C68 1985. Descriptors: human infants, gastrointestinal disorders, intestinal resection, malabsorption, mucosal atrophy, mucosal brush border enzymes, malabsorption, gastrostomy, IV feedings. 253 "Vitamin D metabolism in the pig." G.W. Engstrom and E.T. Littledike. In: Swine in Biomedical Research M.E. Tumbleson (ed.), Vol. 2. Plenum Press, New York; 1986, pp. 1091-1112. NAL call number: RB125.C68 1985. Descriptors: calcium, phosphorus, D2, D3, ultraviolet light, metabolic pathway, hydroxylase, age effects on plasma vitamin D metabolites, maternal neonate vitamin D exchange, toxicity, calcium binding protein, bone resorption. 254 "Serum lipoproteins in cholesterol-fed pigs after partial ileal bypass." J.A. Schouten, A.C. Beynen, and H.F.W. Hoitsma. Laboratory Animals 19(2):98-105(1985). Descriptors: hypercholesterolemia, lipoprotein blood level, lipoprotein metabolism. 255 "Description of a new, versatile porcine model to study mammalian renal hydroxylase regulation in vitro in the D replete state." E.M. Spencer, T.K. Hunt Jr., and D. Marshall. In: Vitamin D: Chemical, Biochemical and Clinical Endocrinology of Calcium Metabolism (eds.) A.W. Norman, K. Schaefer, D. von Herrath, H.G. Grigoleit. Walter De Gruyter, Berlin. 1982. pp. 507-510. NAL call number: QP772.V53W67 1985. Descriptors: calciferol, nutrition deficiency, 2-5- hydroxycholecalciferol-1 alpha hydroxylase. ------------------------------------------------------------ URINARY SYSTEM 256 "The anephric micropig as a model for peritoneal dialysis." S.K. Webster, M.A. DeLeo, and K.E. Burhop. In: Swine as Models in Biomedical Research M.M. Swindle, D.C. Moody, and L.D. Phillips (eds.), Iowa State University Press, IA; 1992, pp. 64-73. NAL call number: RB125 S79 1992 Descriptors: catheter implantation, Yucatan micropigs, partial nephrectomy, uremia.t 257 "DOCA-treated Yucatan miniature swine: A neurogenic model of essential hypertension." E.J. Zambraski, G.D. Thomas and K.P. O'Hagan. In: Swine as Models in Biomedical Research M.M. Swindle, D.C. Moody, and L.D. Phillips (eds.), Iowa State University Press, IA; 1992, pp. 290-301. NAL call number: RB125 S79 Descriptors: deoxycorticosterone-acetate, sympathetic nervous system, renal sympathetic nerve activity, mean arterial pressure. 258 "Renal transplantation in swine." L.R. Pennington. In: Swine as Models in Biomedical Research M.M. Swindle, D.C. Moody, and L.D. Phillips (eds.), Iowa State University Press, IA; 1992, pp. 35-43. NAL call number: RB125 S79 1992 Descriptors: allografts, rejection, orthotopic and heterotopic techniques. 259 "Simultaneous en-bloc allotransplantation of pancreas and kidney in a large animal-model -- Comparison of en-bloc vs separate pancreas and kidney-transplantation in the pig." R. Grussner and D. Sutherland. Zentralblatt Fur Chirurgie 117(11):607-615(1992). Descriptors: pancreas-kidney transplantation, cystoscopic transduodenal biopsy, duodenocystostomy. 260 "Application of P-31 nuclear magnetic resonance spectroscopy to a new experimental kidney perfusion model using cadaveric porcine kidneys from slaughterhouse." R. Lietzenmayer, E. Henze, R. Knorpp, C. Schwamborn, M. Clausen, G. Schnur, and W.E. Adam. Nephron 57(3):340-348(1991). Descriptors: kidney perfusion, kidney preservation. 261 "Computed tomography after extracorporeal shock wave lithotripsy (ESWL) of the kidneys. Part I: Acute findings with histopathological correlation in an animal model." T. Schaub, M. Kunisch, M. Stadbaumer, S. Storkel, H. El- Damanhoury, H.J. Hennes, H. Schild, and M. Thelen. ROFO: Fortschritte Auf Dem Gebiete Der Rontgenstrahlen Und Der Neuen Bildgebenden Verfahren 154(3):231-237(1991). Descriptors: extracorporeal lithotripsy, computer assisted tomography, kidney hemorrhage, histopathology. 262 "Goal directed therapy with dobutamine in a porcine model of septic shock: Effects on systemic and renal oxygen transport." G.A. Haywood, D. Tighe, R. Moss, N. Al-Saady, T.O.A. Foshola, S.P. Riley, I. Pearson, A. Webb, W.J. McKenna, and E.D. Bennett. Postgraduate Medical Journal 67(Suppl. 1):s36- s41(1991). Descriptors: kidney blood flow, oxygen transport, septic shock therapy, heart output, oxygen consumption, intravenous drug administration. 263 "Image guided localized 31P magnetic resonance spectroscopy of acute urinary tract obstruction." F. Parivar, P.B. Barker, P.T. Narasimhan, L.W. Jones, and B.D. Ross. Journal of Urology 145(3):657-662(1991). NAL call number: 448.8 J8234 Descriptors: kidney pelvis, nuclear magnetic resonance imaging, phosphorus 31. 264 "Induction of kidney transplantation tolerance across major histocompatibility complex barriers by bone marrow transplantation in miniature swine." P.C. Guzzetta, T.M. Sundt, T. Suzuki, A. Mixon, B.R. Rosengard, and D.H. Sachs. Transplantation 51(4):862-866(1991). NAL call number: QP89 T73 Descriptors: lymphohenatopoietic chimerism, lymphocyte reaction, miniature swine, T cells, BUN, serum cretinine. 265 "Shock wave lithotripsy-induced renal injury." A.P. Evan, L.R. Willis, B. Connors, G. Reed, J.A. McAteer, and J.E. Lingeman. American Journal of Kidney Diseases 17(4):445-450(1991). Descriptors: kidney injury, nephron, blood pressure, kidney function, extracorporeal lithotripsy. 266 "An animal model of non-obstructive bladder instability." K.K. Sethia, A.F. Brading and J.C. Smith. Journal of Urology 143(6):1243-1246(June 1990). Descriptors: bladder, innervation, neurogenic, muscle contraction, smooth muscle physiopathology, urodynamics, miniature swine. 267 "Comparison of bioeffects of open surgery percutaneous surgery and extracorporeal shock wave lithotripsy on renal function and morphology in the farm pig creation of an animal model." R.B. David, G.J. Fuchs, and Z. Barbaric. Journal of Endourology 49(1):27-36(1990). Descriptors: renin angiotensin system, nephrogenic hypertension, nephrotomy stone therapy. 268 "Detection renal scarring by DMSA scanning - An experimental study." A.J. Arnold, S.M. Brownless, H.M. Carty, and A.M.K. Rickwood. Journal of Pediatric Surgery 25(4):391-393(1990). Descriptors: kidney scar complications, kidney scintiscanning, urinary tract infection, vesicoureteral reflux, diagnostic value, radioisotope. 269 "Modification of hyperactive xenograft rejection by ex-vivo xenoantibody adsorption." L.K. Han, M.L. Henry, C.G. Orosz, D.D. Sedmak, and R.M. Ferguson. Current Surgery 47(1):15-17(1990). Descriptors: pig, dog, model, kidney immunoadsorption, plasmapheresis, sequential organ transplant, hemoperfusion. 270 "Renal denervation decreases blood pressure in doca treated miniature swine with established hypertension." K.P. O'Hagan, G.D. Thomas, and E.J. Zambraski. American Journal of Hypertension 3(1):62-64(1990). Descriptors: deoxycorticosterone, sodium acetate, mean arterial pressure, surgical denervation. 271 "The application of renal cells in culture in studying drug induced nephrotoxicity." P.D. Williams. In Vitro Cellular and Developmental Biology 25(9):800-805(1989). NAL call number: QH585 A1I58 Descriptors: rabbit, pig, cic diamminedichloroplatinum, antineoplastic agent, pharmacotoxicity, bidirectional transport, pathogenesis, in vitro model. 272 "Glomerular basement membrane as a compressible ultrafilter." G.B. Robinson and H.A. Walton. Microvascular Research 38(1):36-48(1989). Descriptors: pig, cytochrome C, myoglobin, lysozyme, ovalbumin, lactoglobulin, serum albumin, in vitro model. 273 "Modulation of noradrenaline and neuropeptide Y NPY release in the pig kidney in vivo involvement of alpha-2 NPY and angiotensin II receptors." J. Pernow and J.M. Lundberg. Naunyn-Schmiedeberg's Archives of Pharmacology 340(4):379-385(1989). NAL call number: 448.8 Ar2 Descriptors: alpha 2 adrenoceptor, renal blood flow control, nerve stimulation. 274 "Reducing renal injury during transplantation." J.L.R. Forsythe, P.M. Dunnigan, G. Proud, T.W.J. Lennard, and R.M.R. Taylor. British Journal of Surgery 76(10):999-1001(1989). Descriptors: kidney injury, kidney transplantation, temperature. 275 "Reproducibility of Iodine-123-Hippuran renoscintigraphy in the normal pig at various flow rates." J. Frokiaer, L. Knudsen, C. Flo, H.H. Hansen, B. Eika, J. Mortensen, and F.T. Jensen. Scandinavian Journal of Urology and Nephrology Supplement 0(125):87-93(1989). Descriptors: diagnostic drug, urine flow, parenchyma, pelvis, transit times, diuresis, renography. 276 "Use of verapamil with conventional immunosuppression after porcine renal transplantation." D. Kahn, R. Hickman, C. Dreyer, and C.T. Camp. European Surgical Research 21(3-4):156-161(1989). Descriptors: metabolic drug, cyclosporin, solumedrol, immunosuppressant drug, histology. 277 "Ablation of free radical-mediated reperfusion injury for the salvage of kidneys taken from non-heartbeating donors: A quantitative evaluation of the proportion of injury caused by reperfusion following periods of warm, cold, and combined warm and cold ischemia." T. Hoshino, W.R. Maley, G.B. Bulkley, and G.M. Williams. Transplantation 45(2):284-289(1988). NAL call number: QP89 T73 Descriptors: kidney transplantation, kidney failure, creatinine clearance, cadaver kidney. 278 "Modification of sodium potassium-atpase of the pig kidney by endogenous phospholipids." I.I. Ismailov and Z.U. Bekmukhametova. Khimiia Prirodnykh Soedinenii 0(6):872-873(1988). NAL call number: QD241 K45 Descriptors: protein lipid relationship, sonication. 279 "A prototype device for nonimmersion shock wave lithotripsy using ultrasonography for calculus localization." F.F. Marshall, F. Weiskopf, A. Singh, F. Mark, F. Leo, R. Sanders, R. Makofski, P.C. Walsh, and N. Smith. Journal of Urology 140(2):249-253(1988). NAL call number: 448.8 J8234 Descriptors: ultrasound, transducer nephrolithiasis therapy, extracorporeal lithotripsy, renal calculi, nonoperative method, dwarf pigs, kidney stones. 280 "Absence of renal 25-hydroxycholecalciferol-1-hydroxylase activity in a pig strain with vitamin D-dependent rickets." I. Winkler, F. Schreiner, and J. Harmeyer. Calcified Tissue International 38(2):87-94(1986). Descriptors: hydroxylase deficiency, rickets metabolism, vitamin D. 281 "Model for chronic obstruction and hydronephrosis." C.E. Constantinou, C.J. Djurhuus, L. Vercesi, A.J. Ford and J.D. Meindl. In: Swine in Biomedical Research M.E. Tumbleson (ed.), Vol. 3. Plenum Press, New York; 1986, pp. 1711-1724. NAL call number: RB125.C68 1985. Descriptors: artificial chronically implanted sphincter, implantable telemetry system, bladder and renal pelvic pressure, hydrostatic pressure, EMG. 282 "The pig as a model for studying kidney disease in man." C.J. Hodson. In: Swine in Biomedical Research M.E. Tumbleson (ed.), Vol. 3. Plenum Press, New York; 1986, pp. 1691-1709. NAL call number: RB125.C68 1985. Descriptors: obstruction, vesicoureteral reflux, papillae, surgery, ligated ureters, urethral stenosis, reflux neuropathy, cystography, urogram, kidney stone, histology, scarring. 283 "Swine as a model in renal physiology and nephrology: An overview." J.M. Terris. In: Swine in Biomedical Research M.E. Tumbleson (ed.), Vol. 3. Plenum Press, New York; 1986, pp. 1673-1689. NAL call number: RB125.C68 1985. Descriptors: human, multipyramidal kidney, renal development and differentiation, papillary morphology, pyeloureteral dynamics, vesicoureteral reflux, pyelotubular backflow, renal lymphatics, renal hemodynamics, diuretics. 284 "The role of Tamm-Horsfall protein in the pathogenesis of reflux nephropathy and chronic pyelonephritis." V.T. Andriole. Yale Journal of Biology and Medicine 58(2):91-100(1985). Descriptors: reflux nephropathy, vesicoureteral reflux, autoimmunity, rabbit, swine. 285 "Urodynamische Untersuchungen nach anisoperistaltischen end zu end ureteranastomos en am Tiermodell Schwein. [Urodynamic studies following anisoperistaltic end to end ureter anastomoses in the swine animal model.]" D. Oehler, U. Munnich, J. Schneider, and F. Audorf. Zeitschrift fur Urologie und Nephrologie 78(3):125-136(March 1985). Descriptors: ureter surgery, urinary diversion methods, urodynamics, hydrostatic pressure, muscle contraction. 286 "Description of a new, versatile porcine model to study mammalian renal hydroxylase regulation in vitro in the D replete state." E.M. Spencer, T.K. Hunt Jr., and D. Marshall. In: Vitamin D: Chemical, Biochemical and Clinical Endocrinology of Calcium Metabolism A.W. Norman, K. Schaefer, D. von Herrath, H.G. Grigoleit (eds.), Walter De Gruyter, Berlin. 1982. pp. 507-510. NAL call number: QP772.V53W67 1985. Descriptors: hydroxylase activity, kidney function, 1,24 hydroxylase. ------------------------------------------------------------ REPRODUCTION 287 "The influence of exogenous gonadotrophins and cloprostenol on ovulation in gilts." R.N. Kirkwood, P.A. Thacker, and R.K. Chaplin. Canadian Veterinary Journal 32(12):742-746(1991). NAL call number: 41.8 R3224 Descriptors: ovary follicle, corpus luteum, laparotomy. 288 "Staphylococcus hyicus abortion in a sow." G.E. Onet and J.L. Pommer. Journal of the American Veterinary Medical Association 199(3):362-363(1991). NAL call number: 41.8 Am3 Descriptors: cefalotin, tetracycline, staphylococcus infection, antibiotic resistance. 289 "Functional differentiation and regulation of the ovaries and placenta a direct action of growth factors on the cellular level." T. Maruo. Clinical Gynecology and Obstetrics 43(3):209-224(1989). Descriptors: human, porcine, rabbit, thyroid hormone, insulin, insulin-like growth factor, FSH, luteinizing hormone, human chorionic gonadotropin. 290 "Sources of the autonomic and afferent fibers to the clitoris in pig." S. Flieger, J. Welento, Z. Boratynski, J. Krzyzanowski, and J. Slamwomirski. Folia Morphologica 47(1-4):83-88(1988). NAL call number: 444.8 C33 Descriptors: spinal cord ganglia, model. 291 "Sources of the autonomic and afferent fibers to the horns and body of the uterus in the pig." S. Flieger, Z. Boratynski, J. Welento, J. Krzyzanowski, and J. Slawomirski. Folia Morphologica 47(1-4):77-82(1988). NAL call number: 444.8 C33 Descriptors: brain stem, spinal cord ganglia, model. 292 "Sources of autonomic and afferent fibers to the uterine cervix in pig." Z. Boratynski, S. Flieger, J. Welento, J. Krazyza-Nowski, and J. Slawomirski. Folia Morphologica 47(1-4):71-76(1988). NAL call number: 444.8 C33 Descriptors: spinal cord, spinal ganglia, model. 293 "Differentiation of sexual behavior." J.J. Ford and R. K. Christenson. In: Swine in Biomedical Research M.E. Tumbleson (ed.), Vol. 1. Plenum Press, New York; 1986, pp. 191-200. NAL call number: RB125.C68 1985. Descriptors: boars, sows, estrogens, amniotic fluid, testosterone, reproductive behavior. 294 "Hypophysectomy and hypophysial stalk transection in the pig: Technique and application to studies of ovarian follicular development." R.R. Kraeling, C.R. Barb and G.B. Rampacek. In: Swine in Biomedical Research M.E. Tumbleson (ed.), Vol. 1. Plenum Press, New York; 1986, pp. 425-433. NAL call number: RB125.C68 1985. Descriptors: gilts, graafian follicles, LH, hormone secretion, PMSG. 295 "Use of exogenous gonadotropin and embryo transfer to study reproductive efficiency in altrenogest synchronized miniature swine." J.R. Diehl, K.J. Lipetz, L.D. Stuart and D.E. Wildt. In: Swine in Biomedical Research M.E. Tumbleson (ed.), Vol. 1. Plenum Press, New York; 1986, pp. 135-142. NAL call number: RB125.C68 1985. Descriptors: estrus synchronization, ovulation, PMSG, HCG, total corpea lutea, cystic endometrial hyperplasia, altrenogest, National Institutes of Health miniature pig. ------------------------------------------------------------ IMMUNOLOGY 296 "Analysis of T lymphocyte subsets proliferating in response to infective and UV-inactivated African swine fever viruses." A. Canals, F. Alonso, J. Tomillo, and J. Dominguez. Veterinary Microbiology 33:(1-4):117-127(1992). NAL call number: SF 601 V44 Descriptors: monoclonal antibody, cd4 antigen, cd8 antigen, cellular immunity, virus attenuation. 297 "Awake porcine model of intraperitoneal sepsis." L.D. Hoban, J.A. Paschall, J. Eckstein, V. Nadkarni, C.R. Lee, T.J. Williams, D.Reusch, J.J. Nevola, and J.A. Carcillo. In: Swine as Models in Biomedical Research M.M. Swindle, D.C. Moody, and L.D. Phillips (eds.), Iowa State University Press, IA; 1992, pp. 246-264. NAL call number: RB125 S79 Descriptors: E. coli strain B7, hemodynamic measurements, lipopolysaccharide levels, tumor necrosis factor. 298 "Characterization of p20 gene sequences from a border disease- like pestivirus isolated from pigs." P.M. Roehe, M.J. Woodward, and S. Edwards. Veterinary Microbiology 33(1-4):231-238(1992). NAL call number: SF601 V44 Descriptors: virus characterization, protein analysis, virus classification, amino acid sequence. 299 "Contribution of single genes within the unique short region of Aujeszky's disease virus (suid herpesvirus type 1) to virulence, pathogenesis and immunogenicity." T.G. Kimman, N. De Wind, N. Oei-Lie, J.M.A. Pol, A.J.M. Berns, and A.L.J. Gielkens. Journal of General Virlolgy 73(2):243-251(1992). NAL call number: QR360 A1J6 Descriptors: pseudorabies herpetovirus, virus excretion, virus virulence, oropharynx, protein kinase, antibody response. 300 "Effect of various vaccination procedures on shedding, latency, and reactivation of attenuated and virulent pseudorabies virus in swine." W.L. Mengeling, K.M. Lager, D.M. Volz, and S.L. Brockmeier. American Journal of Veterinary Research 53(11):2164-2173(1992). NAL call number: 41.8 Am3A Descriptors: virus vaccine, rabies vaccine dexamethasone, immunization, veterinary medicine. 30 "An experimental model for subclinical edema disease (Escherichia coli enterotoxemia) manifest as vascular necrosis in pigs." F.M. Kausche, E.A. Dean, L.H. Arp, J.E. Samuel, and H.W. Moon. American Journal of Veterinary Research 53(3):281-287(March 1992). NAL call number: 41.8 Am3A Descriptors: latent infections, disease models, oral administration. 302 "Immune response of pigs to parenteral vaccination with an aromatic-dependent mutant of Salmonella typhimurium." J.S. Lumsden, and B.N. Wilkie. Canadian Journal of Veterinary Research 56(4):296-302(1992). NAL call number: SF601 C24 Descriptors: salmonellosis vaccine, salmonella typhimurium, immune response, oral drug administration. 303 "Pathogenicity and antigen detection of the Nouzilly strain of transmissible gastroenteritis coronavirus, in 1-week-old piglets." M.J. Cubero, S. Bernard, L. Leon, P. Berthon, and A Contreras. Journal of Comparative Pathology 106(1):61-72(1992). NAL call number: 41.8 J82 Descriptors: immunohistochemistry, intestine, virogenesis, tissue distribution, jejunum, ileum, mesentery lymph node, tonsil, spleen, kidney, liver, lung, newborn, oral drug administration. 304 "Role of different genes in the virulence and pathogenesis of Aujeszky's disease virus." T.G. Kimman, J.M.A. Pol, N. De Wind, N. Oei-Lie, A.J.M. Berns, and A.L.J. Gielkens. Veterinary Microbiology 33(1-4):45-52(1992). NAL call number: SF601 V44 Descriptors: protein kinase, neutralizing antibody, virus vaccine, virus infection prevention, provocation test, cytotoxic t lymphocyte, animal tissue, conference paper, oropharynx. 305 "Synthesis and structure-activity relationships of 7- diazabicycloalkylquinolones, including danofloxacin, a new quinolone antibacterial agent for veterinary medicine." P.R. McGuirk, M.R. Jefson, D.D. Mann, N.C. Elliott, P. Chang, E.P. Cisek, C.P. Cornell, T.D. Gootz, S.L. Haskell, M.S. Hindahl, L.J. LaFleur, M.J. Rosenfeld, T.R. Shryock, A.M. Silvia, and F.H. Weber. Journal of Medical Chemistry 35(4):611-620(1992). NAL call number: RS403 A1J6 Descriptors: quinoline derived antiinfective agent, bacterial infection, antibacterial activity, gram positive and negative bacterium, enzyme inhibition. 306 "Cross protection among Haemophilus parasuis strains in immunized gnotobiotic pigs." O.P. Miniats, N.L. Smart, and S. Rosendal. Canadian Journal of Veterinary Research 55(1):37-41(1991). NAL call number: SF601 C24 Descriptors: vaccination, immunization, gnotobiotics, haemophilus parasuis. 307 "Efficacy of a pseudorabies virus vaccine based on deletion mutant strain 783 that does not express thymidine kinase and glycoprotein I." J.T. Van Oirschot, R.J.M. Moormann, A.J.M. Berns, and A.L.J. Gielkens. American Journal of Veterinary Research 52(7):1056-1060(1991). NAL call number: 41.8 Am3A Descriptors: virus vaccine, pseudorabies herpetovirus, intranasal administration. 308 "Evaluation of live avirulent Escherichia coli vaccine for k88+, LT+ enterotoxigenic colibacillosis in weaned pigs." D.H. Francis and J.A. Willgohs. American Journal of Veterinary Research 52(7):1051-1055(1991). NAL call number: 41.8 Am3A Descriptors: escherichia coli vaccine, diarrhea, vaccination. 309 "Resistance to antimicrobial agents and prevalence of R plasmids in Pasteurella multocida from swine." S. Cote, J. Harel, R. Higgins, and M. Jacques. American Journal of Veterinary Research 52(10):1653-1657(1991). NAL call number: 41.8 Am3A Descriptors: streptomycin, sulfafurazole, bacterial infection, antibiotic sensitivity. 310 "Vaccination against progressive atrophic rhinitis with a recombinant Pasteurella mutocida toxin derivative." J.P. Nielsen, N.T. Foged, V. Sorensen, K. Barfod, A. Bording, and S.K. Petersen. Canadian Journal of Veterinary Research 55(2):128-138(1991). NAL call number: SF601 C24 Descriptors: immunization, gilts, bordetella bronciseptica, turbinate atrophy. 311 "Vaccination of gnotobiotic primary specific pathogen-free pigs against Haemophilus parasuis." O.P. Miniats, N.L. Smart, and E. Ewert. Canadian Journal of Veterinary Research 55(1):33-36(1991). NAL call number: SF601 C24 Descriptors: haemophilus vaccine, immunization, septicemia, polyarthritis. 312 "Virulence of Streptococcus suis type 2 strains in newborn germfree pigs depends on phenotype." U. Vecht, H.J. Wisselink, J.E. Van Dijik, and H.E. Smith. Infection and Immunology 60(2):550-556(1991). NAL call number: QR1 I57 Descriptors: lysozyme, inoculation, bordetella bronchiseptica, meningoencephalitis, polyarthritis, serosa, electrophoresis, immunoblotting, newborn. 313 "Antigen-specific transplantation tolerance." D.H. Sachs. Clinical Transplantation 4(2):78-81(1990). Descriptors: graft survival, membrane antigen, immune response. 314 "Efficacy of a killed gpX deleted pseudorabies virus vaccine." D.R. Cook, H.T. Hill, and D.R. Kinker. Canadian Journal of Veterinary Research 54(4):438-445(1990). NAL call number: SF601 C24 Descriptors: pseudorabies herpetovirus, antibodies, glycoproteins, inactivated vaccine. 315 "Efficacy of tiamulin against experimentally induced Streptococcus suis type-2 infection in swine." M.M. Chengappa, L.W. Pace, J.A. Williams, C.H. Herren, and S.E. Ascher. Journal of the American Veterinary Medical Association 197(11):1467-1470(1990). NAL call number: 41.8 Am3 Descriptors: bacterial infection, meningitis, pneumonia, pleurisy, pericarditis. 316 "Minimal infective dose of the OSU strain of porcine rotavirus." P. Payment and E. Morin. Archives of Virology 112(3-4):277-282(1990). Descriptors: contamination, rotavirus, feces, nosocomial environments, diarrhea. 317 "Radioimmunotargeting of human tumour cells in immunocompetent animals." J.G. Field, O.S. Bruland, H.B. Benestad, L. Schjerven, T. Stigbrand, and K. Nustad. British Journal of Cancer 62(4):573-578(1990). NAL call number: RC261 B6 Descriptors: monoclonal antibody, isotope labeling, diffusion chamber, target cell, iodine 125, mouse, swine. 318 "Studies on infection of epidemic hemorrhagic fever virus EHFV on suckling young pigs." C.J. Zeng and Z.G. Xia. Virologica Sinica 4(4):370-374(1989). NAL call number: QR355 P5 Descriptors: neonate, antibody titers, viremia, vaccine test. 319 "Animal models for food sensitivity." C.R. Stokes, B.G. Miller, and F.G. Bourne. In: Food Allergy and Intolerance J. Brostoff and S. Challacombe (eds.), 1987, pp. 286-300. NAL call number: RC596.F6 Descriptors: food allergies, rodents, pigs, ruminants, cell mediated immunity, erythrocytes. "Diarrheal response of gnotobiotic pigs after fetal infection and neonatal challenge with homologous and heterologous human rotavirus strains." A. Torres and L. Ji-Huang. Journal of Virology 60(3):1107-1112(1987). Descriptors: piglet diseases, viral disease, experimental infection. 321 "Tissular expression of ABH and Lewis antigens in humans and animals: Expected value of different animal models in the study of ABO-incompatible organ transplants." R. Oriol. Transplantation Proceedings 19(6):4416-4420(December 1987). Descriptors: ABO blood group, immunology, dogs, rabbits, primates, swine, rodents, genetics, glucosyltransferases, Lewis blood group, tissue distribution. 322 "The behavior of pig lymphocyte populations in vivo." R.M. Binns, R. Pabst, and S.T. Licence. In: Swine in Biomedical Research M.E. Tumbleson (ed.), Vol. 3. Plenum Press, New York; 1986, pp. 1837-61-70. NAL call number: RB125.C68 1985. Descriptors: lymphocyte migration, antigens, Peyer's patch types, T and B lymphocytes, Null cells, thymocytes. 323 "Partial splenectomy and autotransplantation of splenic fragments in pigs: A model for prevention of septicemia." P. Reinhard and R.M. Binns. In: Swine in Biomedical Research M.E. Tumbleson (ed.), Vol. 3. Plenum Press, New York; 1986, pp. 1955-1961. NAL call number: RB125.C68 1985. Descriptors: traumatic spleen injuries in humans, splenic fragment regeneration, German Landrace, miniature Gottingen, surgery, splenic transplantation, partial splenectomy, splenic ligation, histology. 324 "Swine as a model for the study of maternal neonatal immunoregulation." J.E. Butler, F. Klobasa, E. Werhahn, and J.C. Cambier. In: Swine in Biomedical Research M.E. Tumbleson (ed.), Vol. 3. Plenum Press, New York; 1986, pp. 1883-1899. NAL call number: RB125.C68 1985. Descriptors: passive humoral immunity, newborns, species differences, piglets, colostrum, blood sampling, IgG, IgA and IgM concentration, antibody production to phosphorylcholine and fluorescein, ELISA. ---------------------------------------------------------- STRESS 325 "Stress in swine 1979-August 1988." J.C. Swanson. Quick Bibliography Series (USDA, NAL) 91-16:36p. (November 1990). NAL call number: aZ5071.N3 no.91-16 Descriptors: bibliography, immunology, temperature, housing, behavior, porcine stress syndrome, transport, production. 326 "Adrenal and behavioral responses of swine restricted to varying degrees of mobility." B.A. Becker, R.K. Christenson, J.J. Ford, J.A. Nienaber, J.A. Deshazer, and G.L. Hahn. Physiology and Behavior 45(6):1171-1176(1989). NAL call number: QP1.P4 Descriptors: chronic stress, cortisol, ACTH, model. 327 "Endocrine and behavior changes associated with intensive housing systems for swine." B.A. Becker, J.J. Ford, J.A. Nienaber, G.L. Hahn, and R.K. Christenson. In: Swine in Biomedical Research M.E. Tumbleson (ed.), Vol. 1. Plenum Press, New York; 1986, pp. 173-189. NAL call number: RB125.C68 1985. Descriptors: gilts, sows, endocrine glands, animal behavior, pig housing, intensive husbandry. 328 "Home cage visual discrimination device for miniature swine." T.J. Sobotka and R.H. Brown. In: Swine in Biomedical Research M.E. Tumbleson (ed.), Vol. 1. Plenum Press, New York; 1986, pp. 89-94. NAL call number: RB125.C68 1985. Descriptors: stress, animal behavior, neurobehavioral toxicity tests, test apparatus, visual and operant device, shaping, operant conditioning. 329 "Hormone and metabolite changes with stress in pigs." G. Stuart, G. Spencer and K.G. Hallett. In: Swine in Biomedical Research M.E. Tumbleson. Vol. 1. Plenum Press, New York; 1986, pp. 159-165. NAL call number: RB125.C68 1985. Descriptors: jugular vein catheter, transport stress, plasma glucose, insulin, lactate, thyroxine, cortisol, triiodothyronine, somatomedin, free fatty acids. 330 "The impact of handling and environmental factors on the stress response and its consequences in swine." J.L. Barnett and P.H. Hemsworth. Laboratory Animal Science 36(4):366-369(August 1986). NAL call number: 410.9 P94 Descriptors: acute versus chronic stress, behavior, human animal interactions, corticosteroids, housing. 331 "Morphologic and physiologic disorders of environmental stress in swine." P.H. Langner and G.J. Benson. In: Swine in Biomedical Research M.E. Tumbleson (ed.), Vol. 1. Plenum Press, New York; 1986, pp. 173-189. NAL call number: RB125.C68 1985. Descriptors: blood sampling, cannulation, ambient temperature, glucocorticoid. -------------------------------------------------------------- SKELETAL SYSTEM 332 "A bone biopsy procedure for neonatal pigs." D.J. Bobilya, M.G. Maurizi, T.L. Veum, and W.C. Allen. Laboratory Animals 25(3):222-225(1991). NAL call number: QL55 A1 L3 Descriptors: human application, histology. 333 "Induction of kidney transplantation tolerance across major histocompatibility complex barriers by bone marrow transplantation in miniature swine." P.C. Guzzetta, T.M. Sundt, T. Suzuki, A. Mixon, B.R. Rosengard, and D.H. Sachs. Transplantation 51(4):862-866(1991). NAL call number: QP89 T73 Descriptors: lymphohenatopoietic chimerism, lymphocyte reaction, miniature swine, BUN, serum cretinine. 334 "Bone effects of fluoride in animal models in vivo. A review and a recent study." P. Chavassieux. Journal of Bone Mineral Research 5(Suppl. 1):S95-S99(March 1990). Descriptors: drug effects, sodium fluoride, toxicity, pharmacology, bone density, bone diseases, chemically induced, radiograph. 335 "Boron as an antidote to fluorosis? II. Studies on various organs of pigs." W. Seffner, W. Teubener, H. Runde, H. Wiedner, J. Vogt, G. Otto, E. Zschau, D. Geinitz, and J. Franke. Fluoride 23(2):68-79(1990). NAL call number: QP981 F55F55 Descriptors: aluminum, thyroid gland, bone, liver, kidney. 336 "Cartilage inorganic pyrophosphate elaboration is independent of sulfated glycosaminoglycan." L.M. Ryan, I. Kurup, D.J. McCarty, and H.S. Cheung. Arthritis and Rheumatism 33(2):235-240(1990). NAL call number: RC933 A7 Descriptors: pig model, proteoglycan matrix, calcium pyrophosphate, dihydrate xyloside, isotopic sulfate radical, monensin diethylcarbamazine, metabolic drug, chondrocytes, extracellular cysts, calcium pyrophosphate dihydrate, crystal deposition disease. 337 "Estimation of the healing course if denaturated osteoresections orthotopically implanted using an animal model I. Polarization microscopical measurements." F. Keller, W. Wolff, and R. Bocher. Anatomischer Anzeiger 170(3-4):189-197(1990). Descriptors: pig, bone regeneration, histology. 338 "Vertebral end plate failure in porcine and bovine models of spinal fracture instrumentation." D.G. Allan, G.G. Russell, M.J. Moreau, V.J. Raso, and D. Budney. Journal of Orthopaedic Research 8(1):154-156(1990). Descriptors: human model, biomechanical evaluation, load displacement characteristics, fixation devices. 339 "Animal models with chondrodysplasia." R.R. Minor and C.E. Farnum. Pathology and Immunopathology Research 7(1-2):62-67(1988). NAL call number: RB125 P37 Descriptors: osteochondrodysplasias, cattle, poultry, swine and dog diseases, genetics, dwarfism. 340 "Effect of increased weight stress on joint integrity and cathepsin B-like activity of articular cartilage in growing swine." J.J. Brennan, F.X. Aherne, J.R. Thompson and T. Nakano. In: Swine in Biomedical Research M.E. Tumbleson (ed.), Vol. 1. Plenum Press, New York; 1986, pp. 61-70. NAL call number: RB125.C68 1985. Descriptors: gilts, cartilage, cathepsins, weight, growth. 341 "Use of dietary CA and P and photon absorptiometry to predict mechanical properties of bone in swine." T.D. Chrenshaw, D.M. Raab, D.I. Golz and E.L. Smith. In: Swine in Biomedical Research M.E. Tumbleson (ed.), Vol. 2. Plenum Press, New York; 1986, pp. 1085-1090. NAL call number: RB125.C68 1985. Descriptors: human, bone mineral content, bone ash, mechanical force, metatarsal, bone scans, flexure test. ------------------------------------------------------------ DERMATOLOGY 342 "The effect of low-energy laser on skin-flap survival in the rat and porcine animal models." R.J. Smith, M. Birndorf, G. Gluck, D. Hammond, and W.D. Moore. Plastic and Reconstructive Surgery 89(2):306-10(1992). Descriptors: graft survival, lasers, radiation effects, skin, rats, swine. 343 "Prevention of X-ray-induced late dermal necrosis in the pig by treatment with multi-wavelength light." M. Rezvani, M. Nissan, J.W. Hopewell, G.J.M.J. Van den Aardweg, M.E.C. Robbins, and E.M. Whitehouse. Lasers in Surgery and Medicine 12(3):288-293(1992). Descriptors: irradiation, skin necrosis, light exposure, female. 344 "Wound-healing models in the miniature Yucatan pig." M. Chavapil and T.A. Chavapil. In: Swine as Models in Biomedical Research M.M. Swindle, D.C. Moody, and L.D. Phillips (eds.), Iowa State University Press, IA; 1992, pp. 265-289. NAL call number: RB125 S79 Descriptors: epithelization, histology, breed differences, Yucatan, Yorkshire, dressing materials, creams, ointments, growth factors, scar formation. 345 "The Yucatan miniature swine as an in-vivo model for screening skin depigmentation." X. Nair and K.M. Tramposch. Journal of Dermatology Science 2(6):428-433(1991). Descriptors: hydroquinone 4 hydroxyanisole tert butyl catechol, pharmacodynamics, melanocyte concentration, histological evaluation. 346 "Comparison of dolichos-biflorus lectin and other lectin- horseradish peroxidase conjugates in staining of cutaneous blood vessel in the hairless mini pig." D. Darr, K.M. McCormack, T. Manning, S. Duston, D.C. Winston, B.A. Schulte, T.P. Buller, and S.R. Innell. Journal of Cutaneous Pathology 17(1):9-15(1990). Descriptors: angiogenesis, cutaneous wound healing, inflammation, growth pathology. 347 "Dermal and subdermal tissue filling with fetal connective tissue and cartilage, collagen, and silicone: Experimental study in the pig compared with clinical results. A new technique of dermis mini-autograft injections." U.T. Hinderer and J. Escalona. Aesthetic Plastic Surgery 14(4):239-248(1990). Descriptors: implant, fetus, connective tissue, silicone, wound healing. 348 "Effect of single UVR exposure on skin pigmentation and melanocyte morphology in the Yucatan miniature swine." X. Nair and K.M. Tramposch. The Journal of Investigative Dermatology 94 (4):558(1990). NAL call number 448.8 J8292 Descriptors: enlarged dendrites, model. 349 "Identification of growth factor activities of wound fluid collected under hydrocolloid dressings." W.Y.J. Chen and M.J. Lydon. The Journal of Investigative Dermatology 94(4):513(1990). NAL call number: 448.8 J8292 Descriptors: pig, exudate, model. 350 "Biological basis of therapeutic tissue expansion." P.G. Scott and M.M. Chambers. Medical Science Research 17(15):615-618(1989). Descriptors: pig, model, reconstructive surgery, skin stretching, skin expander response, elastic container. 351 "Deferoxamine decreases necrosis in dorsally based pig skin flaps." G.S. Weinstein, M.D. Maves, and M.L. McCormack. Otolaryngology and Head and Neck Surgery 101(5):559-561(1989). Descriptors: metabolic drug, iron, model. 352 "Miniature pig as an animal model to study photoaging." A. Fourtanier and C. Berrebi. Photochemisty and Photobiology 50(6):771-784(December 1989). NAL call number: 382 P56 Descriptors: radiation effects, ultraviolet rays, collagen, electron microscopy, growth and development, skin ultrastructure. 353 "Pulsed electrical stimulation the effect of varying polarity." S.C. Davis, A. Cazzaniga, J.D. Reich, and P.M. Mertz. Clinical Research 37(2):674A(1989). NAL call number: R11 C5 Descriptors: pig, wound healing, dermis electrokeratome, model. 354 "Staphylococcal wound infection in the pig: Part I. Course" P. Svedman, A. Ljungh, A. Rausing, G. Banck, G. Sanden, J. Miedzobrodski, and T. Wadstrom. Annals of Plastic Surgery 23(3):212-218(1989). Descriptors: fibroblast, staphylococcus aureus, histology. 355 "The study of photoablation effect on the skin of an animal model with 193 NM excimer laser." Z.F. Li, Y.F. Yuan, J.N. Wu, and B.K. Gai. Lasers in Surgery and Medicine 0(Suppl. 1):44-45(1989). Descriptors: pig, histology, surgery. 356 "Analysis of epidermal growth tape stripping of skin and explant culture." H. Hammar. ACTA Dermato-Venereologica 68(3):185-191(1988). Descriptors: pig epidermal cells, mitosis, migration, proliferation, in vivo, mathematical analysis. 357 "Animal models of an acquired pigmentary disorder vitiligo." R.E. Boissy and M.L. Lamoreux. Progress in Clinical Biological Research 256:207-218(1988). Descriptors: auto immune response, melanocytes, cytology, species specificity, swine model, duroc pig, poultry models, barred plymouth rock, white leghorn hen. 358 "Experimental models in human melanoma research: A logical perspective." C.W. Beattie, R. Tissot, and M. Amoss. Seminars in Oncology 15(6):500-511(1988). Descriptors: cancer model, carcinogenesis, cell culture, histology, swine. 359 "Clinical chemistry reference values in two breeds of swine and their changes during percutaneous exposure to soman." J.T. James, J.H. Manthei, B.S. Goodwin, D. Heitkamp, and S.P. Liebenberg. American Journal of Veterinary Research 48(2):284-288(1987). NAL call number: 41.8 Am3A Descriptors: dermatotoxicity, skeletal muscle, enzymes, calcium phosphorus. 360 "Collagen biosynthesis and collagen content as a measure of dermal healing in experimental wounds in domestic swine." P.A. Hebda, W.W.Y. Kao, P.M. Mertz and W.H. Eaglstein. In: Swine in Biomedical Research M.E. Tumbleson (ed.), Vol. 1. Plenum Press, New York; 1986, pp. 303-311. NAL call number: RB125.C68 1985. Descriptors: skin, wound healing, collagen biosynthetic capacity, radiolabelled proline. 361 "Enhancement of epidermal regeneration by biosynthetic epidermal growth factor." G.L. Brown, L. Curtsinger III, J.R. Brightwell, D.M. Ackerman, G.R. Tobin, H.C. Polk Jr., C. George-Nascimento, P. Valenzuela, and G.S. Schultz. Journal of Experimental Medicine 163(5):1319-1324(1986). NAL call number: 448.8 J822 Descriptors: dose response, drug efficacy, burn, wound healing, split graft. 362 "Influence of gonadal steroid hormones upon the growth of melanoma in Sinclair swine." M.S. Amoss and C.W. Beattie. In: Swine in Biomedical Research M.E. Tumbleson. Vol. 1. Plenum Press, New York; 1986, pp. 689-698. NAL call number: RB125.C68 1985. Descriptors: gilts, boars, tumor volume scores, estradiol, exophytic tumor dynamics. 363 "The pig as an experimental animal in plastic surgery research for the study of skin flaps, myocutaneous flaps and fasciocutaneous flaps." C.L. Kerrigan, R.G. Zelt, J.G. Thomson, and E. Diano. Laboratory Animal Science 36(4):408-412(1986). Descriptors: flap designs, flap types, tissue circulation, surgery. 364 "Pig skin as test substrate for evaluating topical antimicrobial activity." L.W. Bush, L.M. Benson, and J.H. White. Journal of Clinical Microbiology 24(3):343-348(1986). NAL call number: QR46 J6 Descriptors: disinfectant agent, topical agent, skin, ethanol, bacterium contamination, hand washing, infection prevention, fungus. 365 "A porcine model for evaluating epidermal wound healing." P.M. Mertz, P.A. Hebda, and W.H. Eaglstein. In: Swine in Biomedical Research M.E. Tumbleson (ed.), Vol. 1. Plenum Press, New York; 1986, pp. 291-302. NAL call number: RB125.C68 1985. Descriptors: skin, superficial injuries, factors affecting wound healing, topical agents, dressings, electrokeratome, macroscopic evaluation. 366 "Sinclair swine melanoma." R.R. Hook, C.V. Hamby, and J. Berkelhammer. In: Swine in Biomedical Research M.E. Tumbleson (ed.), Vol. 3. Plenum Press, New York; 1986, pp. 1901-1914. NAL call number: RB125.C68 1985. Descriptors: human melanomas, cutaneous melanoma, selective breeding, tumor development, necropsy, biopsy, histology, hematoxylin and eosin staining, cell culture, malignant neoplasm, cell morphology. 367 "Ultrastructure evaluation of the porcine integument." N.A. Monteiro-Riviere. In: Swine in Biomedical Research M.E. Tumbleson. Vol. 1. Plenum Press, New York; 1986, pp. 641-655. NAL call number: RB125.C68 1985. Descriptors: skin, cell ultrastructure, morphology, smooth muscles, postnatal development, mast cells. 368 "Miniature swine as an animal model in photodermatology: Factors influencing sunburn cell formation." C.P. Sambuco. Photodermatology 2(3):144-150(June 1985). Descriptors: disease models, skin pathology, radiation, dose response relationship, erythema, pigmentation, adverse effects of ultraviolet rays. 369 "Variables affecting the results of xenogenica collagen implantation an animal model." S.K. Grosh, C.W. Hanke, D.P. DeVore, and D.G. Gibbons. Journal of the American Academy of Dermatology 13(5 Part 1):792-798(November 1985). Descriptors: artificial implants, skin surgery, skin biopsy, pathology. 370 "An animal model for aseptic necrosis after intramuscular injections." H. Muller-Vahl and R. Pabst. International Journal of Tissue Reactions 6(3):251-254(1984). Descriptors: femur head chemically induced necrosis, adverse effects of intramuscular injections, adverse effects of intra-articular injections, skin pathology. 371 "Evaluation of animal models for predicting skin penetration in man." W.G. Reinfenrath, E.M. Chellquist, E.A. Shipwash, and W.W. Jederberg. Fundamental and Applied Toxicology 4(2 Part 2):S224-S230(April 1984). NAL call number: RA1190.F8 Descriptors: skin absorption, dogs, isoflurophate metabolism, malonates, inbred BALB C nude mice, skin transplantation, species specificity, swine, thymus gland physiology. 372 "Large animal models of burn hypermetabolism." L.H. Aulick. Proceedings of the International Burn Research Conference Held at San Antonio, Texas of January 19-21, 1983 AD- A149(33):206-210(1984). Descriptors: hypermetabolism, laboratory tests, laboratory animals. 373 "In vitro evidence for the miniature pig as an animal model for familial atypical multiple mole melanoma (FAMMM) syndrome. B.S. Danes and H.T. Lynch. Lab Animal 12(2):42,44(March 1983). NAL call number: QL55.A1L33. Descriptors: Sinclair miniature swine, dermal monolayer cultures, skin biopsy, chromosome number. 374 "Use of the domestic pig as an animal model of human dry skin and for comparison of dry and normal skin properties." D.L. Bissett and J.F. McBride. Journal of Social Cosmetics and Chemistry 34:317-326(1983). Descriptors: water, petrolatum, moisture, lipids, conditioners. ----------------------------------------------------------- PERINATOLOGY 375 "Echocardiographic and anatomic correlation of ventricular septal defect morphology in newborn Yucatan pigs." T.B. Johnson, D.A. Fyfe, R.P. Thompson, C.H. Kline, M.M. Swindle, and R.H. Anderson. American Heart Journal 125(4):1067-1072(1993). Descriptors: heart septal defects, ventricular pathology, ultrasonography. 376 "The effect of varying arterial oxygen tension on neonatal acid-base balance." S.M. Torrance and C. Wittnich. Pediatric Research 31(2):112-116(1992). Descriptors: newborn hypoxia, acidosis, swine. 377 "Endotracheal epinephrine administration technique effects in a pediatric hypoxic-hypercarbic arrest model." M. Jasani, V. Nadkarni, M. Finkelstein, K. Maas, C. Hurst, G. Mandell, and M. Norman. Pediatric Research 31(4 PART2):31A(1992). Descriptors: abstract, pig, hormone-drug resuscitation. 378 "Long-term local effects of intraosseous infusion on tibial bone marrow in the weanling pig model." C.V. Pollack, E.S. Pender, B.N. Woodall, R.C. Tubbs, R.V. Iyer, and H.W. Miller. American Journal of Emergency Medicine 10(N1):27-31(1992). Descriptors: intraosseous infusion, bone marrow, pediatrics, resuscitation. 379 "The role of the Hanford minipig as an animal model in pediatric surgery and neonatal intensive care." I.T. Cohen, S.D. Nelson, and M.P. Hirsh. In: Swine as Models in Biomedical Research M.M. Swindle, D.C. Moody, and L.D. Phillips (eds.), Iowa State University Press, IA; 1992, pp. 57-63. NAL call number: RB125 S79 1992 Descriptors: total parenteral nutrition, congenital gastrointestinal disorders, hepatobiliary complications, cholestasis, enteral stimulation. 380 "Fructose-1, 6-bisphosphate, when given immediately before reoxygenation, or before injury, does not ameliorate hypoxic ischemic injury to the central nervous system in the newborn pig." M.H. LeBlanc, L.A. Raias, O.B. Evans, V. Vig, E.E. Smith, and A.K. Markov. Critical Care Medicine 19(1):75-83(1991). Descriptors: brain pathology, cerebral anoxia, cerebral ischemia, fructosediphosphates pharmacology, fructosediphosphates administration and dosage. 381 "Necrotizing enterocolitis in a neonatal piglet model." I.T. Cohen, S.D. Nelson, R.A. Moxley, M.P. Hirsh, T.C. Counihan, and R.F. Martin. Journal of Pediatric Surgery 26(5):598-601(1991). Descriptors: Hanford minipigs, corotid artery, external jugular vein catheters, hypoxic insult, tonometer, histology. 382 "Tracheal occlusion in the newborn piglet. Effects of sleep state and occlusion timing on arousal and respiratory responses." K.J. Barrington and P.S. Buckner. Journal of developmental Physiology 16(4):217-221(1991). Descriptors: apnea, electroencephalography, electromyography, electrooculography, respiratory airflow, airway obstruction, sleep stages, sleep stages. 383 "Can cholestasis induced by total parenteral nutrition TPN be prevented." J. van Aerde, T. Higa, B. Simmons, A. Wierzbicki, D. Riebel, and G. Chan. Pediatric Research 27(4 Part 2):118A(1990). Descriptors: newborn, pig, jaundice, lipid preparations. 384 "Effect of chylomicron CM secretory blockade on intestinal apolipoprotein APOLP synthesis in the piglet." D.D. Black, and P.L. Rohwer-Nutter. Pediatric Research 27(4 Part 2):101A(1990). Descriptors: triglyceride, cellular regulation. 385 "Effects of ischemia on cholinergic neurotransmission and electrolyte content in newborn pig lumbar spinal cord." P. Tekulics, Z. Rakonczay, P. Szerdahelyi, P. Kasa, and K. Gulya. Life Sciences 46(11):811-818(1990). Descriptors: child hypoxia model, descending aorta. 386 "Hyperthermic death in infancy an animal model." D.S. Jardine and R.H. Haschke. Critical Care Medicine 18(4 Suppl.):S242(1990). Descriptors: piglet, hemorrhagic shock encephalopathy syndrome, lethal, hyperthermia, sudden infant death syndrome, computer model. 387 "Intestinal accumulation of hypoxanthine HX during partial ischemia in newborn swine." S.A. Bustamante. Pediatric Research 27(4 Part 2):102A(1990). Descriptors: DNA, xanthine, hypoxia, countercurrent exchange. 388 "Intestinal hyperemia evoked by nucleotides in newborn swine." S.A. Bustamante. Pediatric Research 27(4 Part 2):102A(1990). Descriptors: infant formula supplementation. 389 "In vivo multinuclear magnetic resonance spectroscopy investigations of cerebral development and metabolic encephalopathy using neonatal animal models." R.J. Corbett. Seminars in Perinatology 14(3):258-271(June 1990). Descriptors: dogs, rabbits, rats, swine, newborn, brain metabolism, nuclear magnetic resonance, disease models. 390 "Lambs L and piglets P have different systemic arterial pressure SAP responses to hypoxemia HYP." M.E. Anderson, D.R. Geiser, D. Faulk and, M. Brown. Pediatric Research 27(4 Part 2):295A(1990). Descriptors: systemic hypertension, pulmonary hypertension. 391 "Low selenium and infant health in Christchurch." B.A Dolamore, K.B. Sluis, J.C. McGrouther, S. Grant, B.A. Darlow, and C.C. Winterbourn. Proceedings of the Nutrition Society of New Zealand 15:181-186(1990). Descriptors: infants, nutritional state, cot death, peroxidation, stress, animal models. 392 "Role of platelet activating factor and eicosanoids during endotoxin induced lung injury in pigs." N.C. Olson, P.B. Joyce, and L.N. Fleisher. American Journal of Physiology 258(6 Part 2):H1674-H1686(1990). NAL call number: 447.8 Am3 Descriptors: escherichia coli, cyclooxygenase, lipoxygenase, hypoxemia, pulmonary edema. 393 "Vasopressin and prostanoid mechanisms in control of cerebral blood flow in hypotensive newborn pigs." W.M. Armstead, C.W. Leffler, D.W. Busija, and R. Mirro. American Journal of Physiology 258(2 Part 2)H408-H413(1990). NAL call number: 447.8 Am3 Descriptors: indomethacin 1-beta, mercapto beta, beta cyclopentamethylebepropionic acid, 2-O-methyltyrosine, arginine, vasopressin, cerebral metabolism, hemorrhage. 394 "Acute hemodynamic response to intravenous enoximone: An animal study and preliminary report in infants after cardiac surgery." D. Schranz, R. Huth, M. Dahm, S. Iversen, E. Hein, H. Stopfkuchen, and B.K. Jungst. Journal of Cardiovascular Pharmacology 14(Suppl. 1):s62-s68(1989). Descriptors: forward heart failure, drug therapy. 395 "Anatomical observations of holoprosencephaly in swine." K.R.S. Fisher, G.D. Partlow, and C.J. Holmes. The Journal of Craniofacial Genetics and Developmental Biology 9(2):135-146(1989). NAL call number: RB155 J6 Descriptors: cyclopia medial proboscis, ear abnormalities, brain malformation, developmental abnormalities. 396 "Blood flow during cardiopulmonary resuscitation with simultaneous compression ventilation in infant pigs." I.D. Berkowitz, T. Chantarojanasiri, R.C. Koehler, C.L. Schleien, J.M. Dean, J.R. Michael, M.C. Rogers, and R.J. Traystman. Pediatric Research 26(6):558-564(1989). Descriptors: cerebral blood flow, myocardium, oxygen uptake, chest deformation. 397 "Cerebral blood flow during experimental hypoxemia and ischemia in the newborn piglet." J.P. Oden, T. Stiris, T.W.R. Hansen, and D. Bratlid. Acta Padiatrica Scandinavica Supplement 0(360):13-19(1989). Descriptors: blood flow reduction, hypoxia. 398 "Digestion and absorption of fish oil by neonatal piglets." S.H. Chiang, J.E. Pettigrew, S.D. Clarke, and S.G. Cornelius. The Journal of Nutrition 119(11):1741-1743(1989). NAL call number: 389.8 J82 Descriptors: eicosapentaenoic acid, lipid hydrolysis, pancreatic lipase. 399 "Effect of L-carnitine supplementation on carnitine status on neonatal pigs." M.T. Coffey, R.B. Shireman, E.E. Jones, and D.L. Herman. The FASEB Journal 3(4):A1264(1989). NAL call number: QH301.F3 Descriptors: liver lipid metabolism. 400 "The gnotobiotic piglet as a model for the pathogenesis of Campylobacter jejuni infection." J. Vitovec, B. Koudela, J. Sterba, I. Tomancova, Z. Matyas, and P. Vladik. International Journal of Medical Microbiology [Zentralblatt fur Bakteriologie] 271(1):91-103(1989). NAL call number: QR1 Z443 Descriptors: colitis, experimental infection, bacterium culture, bacterium identification, scanning electron microscopy, large intestine, edema, inflammation, autopsy, histology, ultrastructure. 401 "Insulin responsiveness of neonatal pig myocardium." R.E. Sicard and J.C. Werner. Biology of the Neonate 56(2):101-108(1989). NAL call number: QH301 B46 Descriptors: metabolic drug, glucose utilization, lactate production. 402 "Mineral bioavailability in neonatal miniature piglets assessed from body and bone composition." R.J. Schanler, S.F. Cheng, and H.P. Sheng. The FASEB Journal 3(4):A1247(1989). NAL call number: QH301 F3 Descriptors: human, model, prematurity, weight gain, calcium, phosphate, salt. 403 "A simplified method for autoregulation of blood flow in the extracorporeal membrane oxygenation circuit." J.B. Atkinson, P. Emerson, R. Wheaton, and C.M. Bowman. Journal of Pediatric Surgery 24(3):251-252(1989). Descriptors: newborn, blood flow, cavitation, air embolism, ventilation perfusion ratio. 404 "Validity of a disposable end tidal carbon dioxide detector to verify endotracheal tube position in piglets." M.S. Bhende and A.E. Thompson. Pediatric Emergency Care 5(4):281-282(1989). Descriptors: capnometry, model. 405 "Factors affecting central inspiratory modulation of hypoglossal motoneuron activity in newborn pigs." A.L. Sica, A.M. Steele, M.R. Gandhi, and N. Prasad. Journal of Developmental Physiology 10(4): 285-295(1988). Descriptors: electrophysiology, vagotomy, motor neurons physiology. 406 "Mechanical properties of fetal minipig lungs after substitution of surfactant with fluorocarbon and dipalmitoylphosphatidylcholine." J. Wuthe, W. Forster, P. Dangel, B. Widjaja, and R. Rufer. Research in Experimental Medicine 188(4):247-253(1988). Descriptors: fluorocarbon, lung surfactant, respiratory distress syndrome. 407 "Absence of beneficial effects of clonidine treatment in a piglet diarrhoea model." V. Cools, E. Cox, and A. Houvenaghel. Medical Science Research 15(20):1263-1264(1987). Descriptors: clonidine adverse drug reaction, clonidine drug therapy, diarrhea drug therapy. 408 "Cerebral blood flow in intoxicated newborn piglets." C.J. MacIntyre, B.Y. Ong, and D.S. Sitar. Canadian Journal of Physiology and Pharmacology 65(1):92-95(1987). Descriptors: microsphere technique, alcoholic intoxication, cerebrovascular circulation, drug effects. 409 "Diarrheal response of gnotobiotic pigs after fetal infection and neonatal challenge with homologous and heterologous human rotavirus strains." A. Torres and L. Ji-Huang. Journal of Virology 60(3):1107-1112(1987). Descriptors: piglet diseases, viral disease, experimental infection, human diseases. 410 "Chronic implantation of catheters and other surgical techniques in fetal pigs." G.C.B. Randall. In: Swine in Biomedical Research M.E. Tumbleson (ed.), Vol. 2. Plenum Press, New York; 1986, pp. 1179-1185. NAL call number: RB125.C68 1985. Descriptors: chronic catheterization, repeat blood sampling, anesthesia, sodium thiopental, maternal vessel catheterization, fetal vessel catheterization, cootid, jugular, femoral, umbilical vein, fetal pituitary, fetal decapitation, hypophysectomy. 411 "A method for nonsurgical creation of patent ductus arteriosus (PDA) and its applications in piglets." J.A. Rysavy, G.E. Lund, J.E. Lock, J.L. Bass, S.S. Einzig, and K. Amplatz. In: Swine in Biomedical Research M.E. Tumbleson (ed.), Vol. 1. Plenum Press, New York; 1986, pp. 243-254. NAL call number: RB125.C68 1985. Descriptors: anesthesia, arteries, catheters, blood pressure. 412 "Selective systemic vasoconstriction with preserved cardiac output during GBS induced pulmonary hypertension piglets: An alternative approach to PPHN?" W.L Meadow, B.F. Rudinsky, and E. Strates. In: Swine in Biomedical Research M.E. Tumbleson (ed.), Vol. 1. Plenum Press, New York; 1986, pp. 243-254. NAL call number: RB125.C68 1985. Descriptors: heart output, systemic diseases, vasoconstrictor agents, streptococcus, respiratory diseases, hypertension. 413 "Swine in perinatal research: An overview." D.E. Hill. In: Swine in Biomedical Research M.E. Tumbleson (ed.), Vol. 2. Plenum Press, New York; 1986, pp. 1155-1159. NAL call number: RB125.C68 1985. Descriptors: catheter implantation, maternal-fetal transfusion, pancreas, insulin, somatomedian, Growth hormone, ATCH, blood pressure, cardiovascular function, pulmonary vascular reactivity, septic shock, hyperalimentation. 414 "Hemodynamic consequences of tolazoline in neonatal group B streptococcal bacteremia: An animal model." W.L Meadow and P.J. Meus. Pediatric Research 18(10):960-965(October 1984). Descriptors: drug effects, septicemia, drug therapy, therapeutic use of tolazoline, newborn, blood pressure, cardiac output, disease models, dose response relationship, streptococcus agalactiae, pathogenicity, vascular resistance, swine. 415 "Necrotizing enterocolitis: A review of animal models." S.L. Topalian and M.M. Ziegler. The Journal of Surgical Research 37(4):320-336 (October 1984). Descriptors: newborn physiology, newborn diseases, asphyxia neonatorum, bacteria physiology, blood volume, breast feeding, adverse effects of catheterization, dogs, enteral feeding, chemically induced enterocolitis, exchange transfusion, whole blood, formulated food, goats, hypertonic solutions, hypothermia, indomethacin, intestinal mucosa, necrosis, rats, swine, umbilical arteries. ------------------------------------------------------------ TOXICOLOGY 416 "Isometamidium in pigs: Disposition kinetics, tissue residues and adverse reactions." L.D.B. Kinabo, Q.A. McKellar, and P.D. Eckersall. Research in Veterinary Science 50(1):6-13(1991). NAL call number: 41.8 R312 Descriptors: isometamidium toxicity, trypanosomiasis, fatality, drug absorption, drug blood level, intramuscular and intravenous administration. 417 "Hepatocellular integrity in swine after prolonged desflurane (I-653) and isoflurane anesthesia: Evaluation of plasma alanine aminotransferase activity." M.A. Holmes, R.B. Weiskopf, E.I. Eger II, B.H. Johnson, and I.J. Rampil. Anesthesia and Analgesia 71(3):249-253(1990). Descriptors: anesthetics, toxicity, aspartate aminotransferase, liver drug effects. 418 "Porcine stress syndrome: An animal model for the neuroleptic malignant syndrome?" P.E. Keck Jr., D.C. Seeler, H.G. Pope Jr., and S.L. McElroy. Biological Psychiatry 28(1):58-62(July 1, 1990). NAL call number: RC321 B55 Descriptors: bromocriptine administration and dosage, haloperidol toxicity, lithium toxicity, chemically induced swine diseases, drug effects on the brain, prevention and control of neuroleptic malignant syndrome, receptors, dopamine. 419 "The response of the pig lung to fractionated doses of x- rays." M. Rezvani and J.W. Hopewell. The British Journal of Radiology 63(745):41-50(1990). Descriptors: mathematical model, gas exchange capacity, radiation induced damage. 420 "Ethanol may stimulate or inhibit sodium potassium ATPase depending upon sodium and potassium concentrations." D.M. Foster, M.D. Huber, and W.R. Klemm. Alcohol 6(6):437-444(1989). Descriptors: rat, pig, model, brain. 421 "Acetaminophen induced acute hepatic failure in pigs: Controversial results to other animal models." D.Henne-Bruns, J. Artwohl, C. Broelsch, and B. Kremer. Research in Experimental Medicine 188(6):463-472(1988). Descriptors: acetaminophen toxicity, liver pathology, chemically induced, dose response relationship, anesthesia. 422 "Behavioral effects of chronic sublethal dietary cyanide in an animal model: Implications for humans consuming cassava (Manihot esculenta)." L.C. Jackson. Human Biology 60(4):597-614(August 1988). Descriptors: behavior of miniature swine, cyanide toxicity, drug effects, adverse effects of diet, random allocation. 423 "Protective cardiovascular effects of diazepam in experimental acute chloroquine poisoning." B. Riou, A. Rimailho, A. M. Galliot, R. Bourdon, and Y. Huet. Intensive Care Medicine 14(6):610-616(1988). Descriptors: antagonists, inhibitors, diazepam administration and dosage, drug screening. 424 "Cerebral blood flow in intoxicated newborn piglets." C.J. MacIntyre, B.Y. Ong, and D.S. Sitar. Canadian Journal of Physiology and Pharmacology 65(1):92-95(1987). Descriptors: microsphere technique, alcoholic intoxication, cerebrovascular circulation, drug effects. 425 "Evaluation of the oesophago-irritant potential of terodiline hydrochloride tablets in three animal models." H.E. Johansson, M. Jonsson and S.G. Olovson. Pharmacology and Toxicology 61(2):148-152(August 1987). Descriptors: butylamine toxicity, calcium channel blockers, chemically induced esophageal diseases, irritants, acute phase reaction, emepronium toxicity, tablets, cats, swine. 426 "The respiratory aspect of the treatment of brain injury associated with acute alcohol intoxication--results of an animal experiment." E. Fenninger, I. Bowdler, R. Novak, A. Grunert, and J. Kilian. Resuscitation 15(2):125-133(1987). Descriptors: blood-gas analysis, electroencephalography, respiratory insufficiency, intracranial pressure, piglets. 427 "A toxin from pasteurella-multocida serogroup D enhances swine herpesvirus 1 replication-lethality in-vitro and in-vivo." M.R. Hall, P.P Williams, and R.B. Rimler. Current Microbiology 15(5):277-282(1987). NAL call number: QR1 C78 Descriptors: pseudorabies virus, severe progressive nasal turbinate atrophy. 428 "Inhibition and adaptation of red cell glucose-6-phosphate dehydrogenase (G6PD) in vivo to chronic sublethal dietary cyanide in an animal model." L.C. Jackson, J.P. Chandler and R.T. Jackson. Human Biology 58(1):67-77(February 1986). Descriptors: cyanide pharmacology, blood, erythrocyte enzymology, glucosephosphate dehydrogenase, body weight, diet, miniature swine. 429 "Considerations for the design, implementation and interpretation of animal models of fetal alcohol effects." E.P. Riley and L.S. Meyer. Neurobehavioral Toxicology and Teratology 6(2):97-101(March-April 1984). Descriptors: behavior, drug effects, fetal alcohol syndrome, psychology, alcohol drinking, anthropoidea, maternal fetal exchange, pregnancy, social environment, dogs, rats, swine. ---------------------------------------------------------- PHARMACODYNAMICS 430 "Efficacy and safety of deferoxamine conjugated to hydroxyethyl starch." S.A. Mousa, R.C. Reger, and R.D. Smith. Journal of Cardiovascular Pharmacology 19(3):425-429(1992). Descriptors: deferoxamine drug therapy, hydroxyethylcellulose drug therapy, lipid peroxidation, heart muscle ischemia, reperfusion injury, drug safety. 431 "In vivo muscle 31P nuclear magnetic resonance spectroscopy during treatment of halothane sensitive and halothane nonsensitive pigs." R. Geers, C. Decammiere, H. Ville, P. Van Hecke, V. Goedseels, F. Vanstapel, L. Bosschaerts, J. De Ley, W. Zhang and S. Janssens. American Journal of Veterinary Research 53(4):613-616(1992). NAL call number: 41.8 Am3A Descriptors: halothane, anesthesia, drug sensitivity, echography, adenosine triphosphate. 432 "Synthesis and structure activity relationships of 7- diazabicycloalkylquinolones, including danofloxacin, a new quinolone antibacterial agent for veterinary medicine." P.R. McGuirk, M.R. Jefson, D.D. Mann, N.C. Elliott, P. Chang, E.P. Cisek, C.P. Cornell, T.D. Gootz, S.L. Haskell, M.S. Hindahl, L.J. LaFleur, M.J. Rosenfeld, T.R. Shryock, A.M. Silvia, and F.H. Weber. Journal of Medical Chemistry 35(4):611-620(1992). NAL call number: RS403 A1J6 Descriptors: quinoline derived antiinfective agent, bacterial infection, antibacterial activity, gram positive and negative bacterium, enzyme inhibition, cattle, swine, nonhuman primate, mouse. 433 "Use of swine in the study of anesthetics." R.B. Weiskopf, M.A. Holmes, E.I. Eger II, N. Yasuda, I.J. Rampil, B.H. Johnson, A.G. Targ, I.A. Reid, and L.C. Keil. In: Swine as Models in Biomedical Research M.M. Swindle, D.C. Moody, and L.D. Phillips (eds.), Iowa State University, IA; 1992, pp. 96-117. Descriptors: aortic blood pressure, pulmonic arterial blood pressure, central venous and pulmonary capillary wedge pressure, cardiac output,desflurane, epinephrine. 434 "Vascular pharmacology of the micropig: Importance of the endothelium." M. FŠlŠtou and B. Teisseire. In: Swine as Models in Biomedical Research M.M. Swindle, D.C. Moody, and L.D. Phillips (eds.), Iowa State University Press, IA; 1992, pp. 74-95. NAL call number: RB125 S79 1992 Descriptors: endothelium physiology, diffusion barrier, acetylcholine, platelets. 435 "Desflurane is a trigger of malignant hyperthermia in susceptible swine." D.J. Wedel, P.A. Iaizzo, and J.H. Milde. Anesthesiology 74(3):508-512(1991). Descriptors: body temperature, blood carbon dioxide, disease susceptibility, inhalation anesthesia. 436 "Evidence for release of endothelin-1 in pigs and humans." A. Rudehill and E. Weitzberg. Journal Cardiovascular Pharmacology 17(Suppl. 7):S350-S353(1991). Descriptors: vasoconstriction, septic shock, mean arterial blood pressure, heart rate, drug clearance, radioimmunoassay, high performance liquid chromatography, fetus, newborn, intravenous drug administration. 437 "Intraosseous administration of lorazepam: Same-dose comparison with intravenous administration in the weanling pig." E.S. Pender, C.V. Pollack, B.N. Woodall, and B.R. Parks. Journal of the Mississippi State Medical Association 32(10):365-368(1991). Descriptors: bone marrow, administration and dosage, pharmacokinetics. 438 "Intraosseous infusion of dobutamine and isoproterenol." J.F. Bilello, K.C. O'Hair, W.C. Kirby, and J.W. Moore. American Journal of Diseases of Children 145(2):165-167(1991). NAL call number: 448.8 Am38 Descriptors: dopamine, isoprenaline, intraosseous drug administration, drug comparison, emergency medicine. 439 "Iron chelation with a deferoxamine conjugate in hemorrhagic shock." D.M. Jacobs, J.M. Julsrud, and M.P. Bubrick. Journal of Surgical Research 51(6):484-490(1991). Descriptors: hydroxyl radical, lipid peroxidation prevention, hemorrhagic shock, reperfusion injury. 440 "New agents - Pentoxifylline and dopexamine." E.D. Bennett. Clinical Intensive Care 2(6 Suppl.):72-82(1991). Descriptors: pentoxifylline, septic shock drug therapy, multiple organ failure, adult respiratory distress syndrome, lung vascular resistance, lactate blood level, oxygen consumption, drug effect, rabbit, swine. 441 "Novel method for measuring growth of Treponema hyodysenteriae and its application for monitoring susceptibility of clinical isolates to antimicrobial agents." F.H. Weber and D.L. Earley. Antimicrobial Agents and Chemotherapy 35(10):2012-2015(1991). NAL call number: RM265 A5132 Descriptors: carbadox, penicillin, metronidazole, novobiocin, gentamicin, lincomycin, drug screening, drug sensitivity, cattle, mouse, swine. 442 "Resuscitation of hypercalcemic arrest. Lack of efficacy of verapamil, magnesium, and bicarbonate in a swine model." B.A. Smith, J.G. Reid, G.P. Moore, D.B. Ferguson, and K.C. O'Hair. Current Therapeutic Research Clinical and Experimental 49(3):458-463(1991). Descriptors: calcium chloride, calcium antagonist, heart arrest, resuscitation. 443 "Sedative and cardiovascular effects of midazolam in swine." A.C. Smith, J.L. Zellner, F.G. Spinale, and M.M. Swindle. Laboratory Animal Care 41(2):157-161(1991). NAL call number: 410.9 P94 Descriptors: echocardiography, midazolam toxicity, pharmacology. 444 "Correlation between drug and metabolite concentrations in plasma and anesthetic action of ketamine in swine." W. Loscher, M. Ganter, and C.P. Fassbender. American Journal of Veterinary Research 51(3):391-398(1990). Descriptors: intramuscular injections, intravenous injections, dosage, pharmacokinetics. 445 "Determination of anti-parasitic drug dosage regimen in veterinary medicine." P. Galtier. Annals of Veterinary Research 21(Suppl. 1):79s-86s(1990). NAL call number: SF602 A5 Descriptors: diamfenetide, levamisole, oxfendazole, parbendazole, triclabendazole, fenbendazole, drug distribution, drug metabolism, drug elimination, dose response, swine, cattle, nonhuman primate, oral and subcutaneous drug administration. 446 "Effect of lithium on DNA synthesis and iodine uptake in porcine thyroid cells in culture." Y. Tsuchiya, M. Saji, O. Isozaki, M. Arai, T. Tsushima, and K. Shizume. Endocrinology 126(1):460-465(1990). NAL call number: 448.8 EN2 Descriptors: antipsychotic agent, side effects, TSH, cyclic AMP, goiter. 447 "Halothane sensitivity of young pigs in vivo and in vitro." R.S. Fay and E.M. Gallant. American Journal of Physiology 259(1 Pt 2):R133-R138(1990). Descriptors: malignant hypothermia susceptible, genetics, halothane, succinylcholine. 448 "Intravenous midazolam suppression of pentylenetetrazol induced epileptogenic activity in a porcine model." D.G. Jaimovich, C.L. Shabino, A. Noorani, B.K. Bittle, and J.S. Osborne. Critical Care Medicine 18(3):313-316(1990). Descriptors: human, anticonvulsant drug seizures, ictal activity, epilepsy, tonic-clonic seizures, diazepam, pentylenetetrazol. 449 "Ranolazine - A new drug with beneficial effects on renal preservation." J.P. Lodge, T. Lam, S.L. Perry, and G.R. Giles. Transplantation 50(5):755-759(1990). NAL call number: QP89 T73 Descriptors: kidney transplantation, organ preservation, surgery, intraarterial dug administration. 450 "Ropivacaine hydrochloride. LEA-103. AL-281. EN = 150269." Drugs Future 15(8):861-862(1990). Descriptors: heart muscle, electric potential, local anesthesia, blood flow, surgery, drug tolerance, hypotension, bradycardia, rabbit, sheep, swine, pregnancy. 451 "Chronic altitude affects hepatic blood flow and caffeine metabolism in miniature swine." G.H. Kamimori, R.W. Hoyt, P.M. Young, V.A. Forte, A. Cymerman, and M.J. Durkot. Medicine and Science in Sports and Exercise 21(2 Suppl.):S62(1989). Descriptors: drug metabolism, enzyme activity, hypobaric chamber, spectrophotometry, high performance liquid chromatography. 452 "Comparison of intraosseous and intravenous routes of anticonvulsant administration in a porcine model." D.G. Jaimovich, C.L. Shabino, T.V. Ringer, and G.R. Peters. Annals of Emergency Medicine 18(8):842-846(1989). Descriptors: phenobarbital, phenytoin, anticonvulsant drug, epilepticus. 453 "The interaction between carbamazepine and erythromycin." P.V. Turner and K.W. Renton. Canadian Journal of Physiology and Pharmacology 67(6):582-586(1989). NAL call number: 444.8 C16 Descriptors: human, pig, rat, anticonvulsant agent, antiinfective agent, decreased elimination, pharmacodynamics, pharmacokinetics, drug interactions, animal model of epilepsy, infection. 454 "Metabolism of I-653 and isoflurane in swine." D.D. Koblin, R.B. Weiskopf, M.A. Holmes, K. Konopka, I.J. Rampil, E.I. Eger II, and L. Waskell. Anesthesia and Analgesia 68(2):147-149(1989). Descriptors: biotransformation, blood fluorides, isoflurane analogs and derivatives, pharmacokinetics. 455 "A minor modification of residue 1 in potent vasopressin antagonists dramatically reduces agonist activity." W.F. Huffman, C. Albrightson-Winslow, B. Brickson, H.G. Bryan, N. Caldwell, G. Dytko, D.S. Eggleston, L.B. Kinter, M.L. Moore, K.A. Newlander, D.B. Schmidt, J.S. Silvestri, F.L. Stassen, and N.C.F. Yim. Journal of Medical Chemistry 32(4):880-884(1989). NAL call number: RS403 A1 J6 Descriptors: vasopressin derivative, drug synthesis, vasopressin receptor, drug receptor binding, diuresis, nuclear magnetic resonance, mass spectrometry, dog, rat, swine. 456 "Pharmacokinetics and central hemodynamic effects of doxorubicin and 4' epidoxorubicin in the pig." M. Andersson, L. Domellof, S. Eksborg, S. Haggmark, G. Johansson, S. Reiz, and A. Herslof. Acta Oncologica 28(5):709-714(1989). Descriptors: antineoplastic drug, cardiotoxicty, pulmonary physiology, myocardial oxygenation. 457 "Reproducibility of iodine-123-hippuran renoscintigraphy in the normal pig at various flow rates." J. Frokiaer, L. Knudsen, C. Flo, H.H. Hansen, B. Eika, J. Mortensen, and F.T. Jensen. Scandinavian Journal of Urology and Nephrology Supplement 0(125):87-93(1989). Descriptors: diagnostic drug, urine flow, parencyma, pelvis, transit times, diuresis, renography. 458 "Intraosseous drug administration." E.B. Hudson and D.F. Thompson. Drug Intelligence and Clinical Pharmacy 22(4):329-330(1988). Descriptors: blood, plasma, drug therapy, sulfathiazole, glucose, bicarbonate, immunoglobulin, topical drug administration, bone, cattle, rabbit, swine, side effects, cellulitis, abscess, hematoma, skin necrosis. 459 "Local and general anesthetic effects on behavior and performance of two- and seven-week-old castrated and uncastrated piglets." J.J. McGlone and J.M. Hellman. Journal of Animal Science 66(12):3049-3058(1988). Descriptors: guaiacolate, xylazine, ketamine, lidocaine, castration, growth, development, pain. 460 "Prenylamine activity on ventricular fibrillation following experimental myocardial infarction ischemia and reperfusion." G.C. Maggi, M.O. Triulzi, and G. Aguggini. Current Therapeutic Research Clinical and Experimental 43(2):335-338(1988). Descriptors: arterial stenosis, pharmacodynamics, antiarrhythmic drug, autonomic drug, calcium antagonist, vasodilator, catecholamine modulation. 461 "Aprotinin and Nasub 2CaEDTA in experimental hemorrhagic pancreatitis in pigs." P. Puolakkainen, A. Paananen, and M. Kaarne. Scandinavian Journal of Gastroenterology 22(1):35-41(1987). Descriptors: drug efficacy, drug toxicity, edentate sodium, aprotinin, phospholipase a2, edetic acid, swine. 462 "Effects of halothane, caffeine, dantrolene and tetracaine on the calcium permeability of skeletal sarcoplasmic reticulum of malignant hyperthermic pigs." S.T. Ohnishi. Biochimie, Biophysique Acta 897(2):261-268(1987). Descriptors: calcium, membrane permeability, anesthetic membrane interaction. 463 "A critical comparison of the hematologic, cardiovascular, and pulmonary response to steroids and nonsteroidal anti- inflammatory drugs in a model of sepsis and adult respiratory distress syndrome." R. Kopolovic, K.M. Thrailkill, and D.T. Martin. Surgery 100(4):679-690(1986). Descriptors: drug comparison, pharmacotherapy, drug efficacy, ibuprofen, methylprednisolone, survival, swine. 464 "Developmental pharmacokinetics of theophylline and caffeine in neonatal piglets." G.L. Kearns, D.E. Hill, C.M. Throneberry, and J.F. Young. In: Swine in Biomedical Research M.E. Tumbleson (eds.), Vol. 2. Plenum Press, New York; 1986, pp. 1303-1312. NAL call number: RB125.C68 1985. Descriptors: serum theophylline and caffeine, HPLC technique, elimination rate constant, total clearance, venous blood sampling. 465 "Drug metabolizing enzyme system of Gottingen miniature pig." K. Fujimori, A. Takahashi, H. Numata, and A. Takanaka. In: Swine in Biomedical Research M.E. Tumbleson (ed.), Vol. 1. Plenum Press, New York; 1986, pp. 533-548. NAL call number: RB125.C68 1985. Descriptors: hexobarbital, aminopyrine, benzo pyrene, aniline, ethylmorphine, N-nitrosoiumethylamine, microsomal cytochrome activity. 466 "Malignant hyperthermia: A pharmacogenetic disease of man and pigs." T.E. Nelson. In: Swine in Biomedical Research M.E. Tumbleson. Vol. 1. Plenum Press, New York; 1986, pp. 261-272. NAL call number: RB125.C68 1985. Descriptors: anesthetics, thiopental, halothane, heart rate, arterial pH, CO2 excretion. 467 "Pharmacodynamic study of drug susceptibility in Gottingen miniature pigs." A. Shimada, H. Lizuka, and T. Yanagita. In: Swine in Biomedical Research M.E. Tumbleson (ed.), Vol. 1. Plenum Press, New York; 1986, pp. 71-76. NAL call number: RB125.C68 1985. Descriptors: d-amphetamine, chlorpromazine, diazepam, behavior, blood pressure, species comparisons, pig, mouse, rat, dog, rhesus monkey. 468 "Reduction of blood loss by triglycyl-lysine-vasopressin during early excision of burns in pigs." E. Vernersson, S. Jacobsson, and M. Aberg. Scandinavian Journal of Plastic and Reconstructive Surgery 18(3):291-296(1984). Descriptors: drug efficacy, trauma, kidney function, terlipressin. ------------------------------------------------------------ NERVOUS SYSTEM 469 "Effects of magnitude and duration of compression on spinal nerve root conduction." R. A. Pedowitz, S.R. Garfin, J.B. Massie, A.R. Hargens, M.R. Swenson, R.R. Myers, and B.L. Rydevik. Spine 17(2):194-199(1992). Descriptors: spinal cord compression, nerve conduction. 470 "Hypertonic fluid resuscitation improves cerebral oxygen delivery and reduces intracranial pressure after hemorrhagic shock." J.D. Schmoker, J. Zhuang, and S.R. Shackford. Journal of Trauma 31(12):1607-1613(1991). Descriptors: hypertonic solution, intracranial pressure, brain injury, head injury. 471 "An improved HPLC-Electrochemical detection method for measuring brain levels of 5-S cysteinyldopamine 5-S cysteinyl-3 4-dihydroxyphenylalanine and 5-S cysteinyl-3 4- dihydroxyphenylacetic acid." B. Fornstedt, I. Bergh, E. Rosengren, and A. Carlsson. Journal of Neurochemistry 54(2):578-586(1990). NAL call number: QP351 J6 Descriptors: neurotoxicity, autotoxidation, high performance liquid chromatography, cat, dog, pig, rabbit, rat. 472 "A quantitative study of some factors affecting the outcome of experimental epidural bleeding in swine." J.C. Ganz, and N.N. Zwetnow. Acta Neurochirurgica 102(3-4):164-172(1990). Descriptors: intracranial pressure, electroencephalograph, hematoma. 473 "Use of a new mixture for embolization of intracranial vascular malformations preliminary experimental experience." P. Lylyk, R. Vinuela, H.V. Vinters, J. Dion, J. Bentson, G. Duckwiler, and T. Lin. Neuroradiology 32(4):304-310(1990). NAL call number: RC349 R3R35 1987 Descriptors: rete mirabile, occlusion, histological changes. 474 "First results of comparative investigation in human and experimental cerebral hemiatrophies." K.G. Pollak. Zhurnal Nevropathologii I Psikhiatrii Imeni S. S. Korsakova 89(10):127-129(1989). Descriptors: brain hemiatrophy diagnosis, brain atrophy, autopsy, histology. 475 "The need for continuous cerebral activity monitoring in treatment of seizures." M. Pourcyrous, G. Stidham, D. Busija, H. Bada, and S. Korones. Pediatric Research 25(4 Part 2)(1989). NAL call number: RJ1 P4 Descriptors: phenobarbital, anticonvulsant drug, newborn, pharmocolgical tool, cotical seizure. 476 "Analysis of the dynamics of experimental epidural bleeding in swine." J.C. Ganz and N.N. Zwetnow. Acta Neurochirurgica 95(1-2):78-81(1988). Descriptors: hematoma, arteriovenous shunt, electroencephalograph. 477 "Factors affecting central inspiratory modulation of hypoglossal motorneuron activity in newborn pigs." A.L. Sica, A.M. Steele, M.R. Gandhi, and N. Prasad. Journal of Developmental Physiology 10(4): 285-295(1988). Descriptors: electrophysiology, vagotomy, motor neurons physiology. ------------------------------------------------------------- OPHTHALMOLOGY 478 "A pig model of acanthamoeba keratitis: Transmission via contaminated contact lenses." Y. He, J.P. McCulley, H. Alizadeh, M. Pidherney, J. Mellon, J.E. Ubelaker, G.L. Stewart, R.E. Silvany, and J.Y. Niederkorn. Investigative Ophthalmology and Visual Science 33(1):126-133(1992). Descriptors: acanthamoeba castellani, keratitis, soft contact lens. 479 "Experimental venous branch occlusion: Modifications of preretinal pO2 induced by dexamethasone." C.J. Pournaras, A. Roth, J.L. Munoz, and R. Abdesselem. Klinische Monatsblatter Fur Augenheilkunde 196(6):475-480(1990). Descriptors: retina vein occlusion, oxygen tension, vitreous body, retina ischemia. 480 "Lectin receptors of normal and dystrophic corneas." N. Panjwani and J. Baum. ACTA Ophthalmolgica Supplement 0(192):171-173(1989). Descriptors: human, cow, rabbit, rat, cat, dog, goat, sheep, pig, model, carbohydrate related abnormality, glycoconjugate, macular, granular, and lattice corneal dystrophy. 481 "Regional water content of clear and cataractous human lenses." A. Deussen and H. Pau. Ophthalmic Research 21(5):374-380(1989). Descriptors: rat, pig, bovine, organ, elasticity, freeze etching technique, model. 482 "Ocular pathology in melanomatous Sinclair miniature swine." L. Feeney-Burns, R.P. Burns, and C.L. Gao. American Journal of Pathology 131(1):62-72(1988). NAL call number: 448.8 Am39 Descriptors: skin melanoma, eye, histology, ultrastructure. ----------------------------------------------------------- PERIODONTOLOGY 483 "The pig as an animal model for experimentation on the temporomandibular articular complex." A. Bermejo, O. Gonzalez, and J.M. Gonzalez. Oral Surgery, Oral Medicine, Oral Pathology 75(1):18-23(1993). Descriptors: anatomy, joint examination, joint function, biomechanics, animal tissue. 484 "Morphological histochemical and biochemical studies on sus- scrofa tooth germs." B. Thonemann and G. Schmalz. Journal of Dental Research 71:656(1992). Descriptors: abstract, organ culture model, odontoblast lactate dehydrogenase activity, pulpal response, dental restorative materials, biocompatibility testing. 485 "Vascular changes in the dental pulp in the hypercholesterolemic miniature swine." B.R. Oguntebi, D.S. Stafford, J. Cerda, and F. Robbins. Oral Surgery, Oral Medicine, Oral Pathology 74(3):351-356(1992). Descriptors: hypercholesterolemia, tooth pulp, blood vessel. 486 "Indirect visualization of the ameloblast modulation in porcine molar tooth germs by EDTA etching and GBHA staining methods." Y. Takano, S. Matsuo, H. Ichikawa, M. Akai, T. Itotagawa, and J. Kato. Journal of Osaka University Dental School 28:63-72(December 1988). Descriptors: ameloblasts, ultrastructure, acid etching, dental, aminophenols, anthropoidea, EDTA, stains and staining, rats, swine. 487 "Electron microscopic demonstration of non-mineralized and hypomineralized areas in dentin and cementum by silver methenamine staining of collagen." M.E. Matthiessen, B. Sogaard-Pedersen, and P. Romert. Scandanavian Journal of Dental Research 93(5):385-395(1985). Descriptors: human, pig, owens contour lines, interglobular, dentin, tomes, granular layer caries. ------------------------------------------------------------- SURGERY AND LABORATORY TECHNIQUES 488 "High dose narcotic anaesthesia using sufentanil in swine and dogs." M.M. Swindle, R.E. Schumann, B.J. Knick, C.L. Case, and P.C. Gillette. In: Proceedings of the 4th International Conference of Veterinary Anesthesia L.W. Hall (ed.), Journal of Veterinary Anesthesia (special supplement):273-276(1993). Descriptors: opioid analgesic infusions, transvenous cryoablation, EKG, blood gases, arterial blood pressure. 489 "Laparoscopic inguinal herniorrhaphy in a swine model. Third place winner of the Conrad Jobst Award in the Gold Medal paper competition." T.S. Layman, R.P. Burns, K.E. Chandler, W.L. Russell, and R.G. Cook. American Surgeon 59(1):13-9(1993). Descriptors: laparoscopy methods, polyethylenes, polytetrafluoroethylene, surgical mesh, testis growth and development. 490 "Intracardiac therapy following emergency thoracotomy in the accident and emergency department: An experimental model." C. Moulton, A. Pennycook, and R. Crawford. Archives of Emergency Medicine 9(2):190-195(1992). Descriptors: thoracotomy, thorax injury, heart injury, emergency medicine, balloon catheter. 491 "Methodologies, devices, and new surgical concepts. Comparison of new iron chelating agents in the prevention of ischemia/reperfusion injury: A swine model of heart-lung transplantation." A.K. Qayumi, W.R.E. Jamieson, A. Poostizadeh, E. Germann, and K.D. Gillespie. Journal of Investigative Surgery 5(2):115-127(1992). Descriptors: drug comparison--cmdeferoxamine, 21 aminosteroid, tirilazad, hydroxyl radical, intravenous drug administration. 492 "Argon beam coagulation is superior to conventional techniques in repair of experimental splenic injury." R.D. Dowling, J. Ochoa, S.A. Yousem, A. Peitzman, and A.O. Udekwu. Journal of Trauma 31(5):717-720(1991). Descriptors: spleen surgery, argon laser. 493 "A bone biopsy procedure for neonatal pigs." D.J. Bobilya, M.G. Maurizi, T.L. Veum, and W.C. Allen. Laboratory Animals 25(3):222-225(1991). NAL call number: QL55 A1 L3 Descriptors: human application, histology. 494 "Establishment of a laparoscopic cholecystectomy training program." R.W. Bailey, A.L. Imbembo, and K.A. Zucker. American Surgeon 57(4):231-236(1991). Descriptors: surgical training, swine, educational video tapes, resident training. 495 "Sedative and cardiovascular effects of midazolam in swine." A.C. Smith, J.L. Zellner, F.G. Spinale, and M.M. Swindle. Laboratory Animal Care 41(2):157-161(1991). NAL call number: 410.9 P94 Descriptors: echocardiography, midazolam toxicity, pharmacology. 496 "Vascular territory expansion: A surgical technique for augmentation of survival of an animal model of musculocutaneous flap." D. Dorion and J.B. Boyd. Journal of Otolaryngology 20(5):320-324(1991). Descriptors: ischemia, plastic surgery, clinical article, myocutaneous flap. 497 "Chronic instrumentation techniques for blood flow and pressure." K. Dormer, D.L. Traber, T. Smith, and T. Patrick. The FASEB Journal 4(4):A1240(1990). NAL call number: QH301 F3 Descriptors: dog, sheep, pig, vasomotor control, flow probe placement, catheter placement, exteriorization, infection, vessel rupture, vessel occlusion, surgical sponge, skin, button. 498 "A closed ileal loop technique for microbiological testing in piglets." J. Thornbury, B. Carlolan, J. Frogley, P. Sibbons, and S. Hardy. Animal Technology: Journal of the Institute of Animal Technology 41(2):71-80(August 1990). NAL call number: AL55 I5 Descriptors: ileum, anastomosis, enterotoxins. 499 "Complete occlusion of the intestinal tract with staples an experimental study and a case report." Y.T.M. Lee, J.A. Ameika, R.R. Marin, and W.S. Stokes. Digestive Surgery 6(4):185-190(1990). Descriptors: knife wounds, ulcer, pig, human, model, pancreatic fistula, clinical application. 500 Essentials of Experimental Surgery J.S.P. Lumley, C.J. Green, P. Lear, and J.E. Angell-James. Butterworth & Co., Boston, MA; 1990, 262p. NAL call number: RD29 E8 Descriptors: legislation, husbandry, handling , body fluid collection, anaesthesia, surgical techniques, microsurgery, biological measurement, species differences. 501 "Intravascular microcatheter pressure monitoring experimental results and early clinical evaluation." G. Duckwiler, J. Dion, F. Vinuela, B. Jabour, N. Martin, and J. Benston. American Journal of Neuroradiology 11(1):169-176(1990). Descriptors: pig, human, mean blood pressure, brain arteriovenous malformation, arteriovenous fistula, fistula, embolization, angiography. 502 "Left lung transplantation in the pig: Technique and results." P. Zannini, A. Baisi, G. Pezzuoli, M. Langer, P. Prato, G. Damia, M. Colledan, S. Gatti, and D. Galmarini. Chirurgia 3(5):210-218(1990). Descriptors: lung transplantation, immunosuppressive treatment, histology, swine, hemodynamic monitoring. 503 "A minimally invasive surgical technique for implantation of a chronically indwelling catheter in swine pulmonary artery." M.A. Holmes and R.B. Weiskopf. Laboratory Animal Science 40(1):93-94(1990). NAL call number: 410.9 P94 Descriptors: hemodynamic studies, chronic indwelling catheter, minimal stress, pulmonary artery, restraint sling, sepsis prevention. 504 "Chronic central vein catheterization for intraoperative and long term venous access in swine." M.W. Mortiz, E.J. Dawe, J.F. Holliday, S. Elliott, J.A. Mattei, and A.L. Thomas. Laboratory Animal Science 39(2):153-155(1989). NAL call number: 410.9 P94. Descriptors: cranial, vena cava, serial blood sampling. 505 "Evaluation of an animal model for teaching fibreoptic tracheal intubation." R.B. Forbes, D.J. Murray, and M.A. Albanese. Canadian Journal of Anaesthesia 36(2):141-144(March 1989). Descriptors: anesthesiology, education, manikins, anatomical model, teaching methods, disease models, swine. 506 "Pressures produced in vitro during intraligamentary anesthesia." A.D. Walmsley, J.M. Lloyd, and E. Harrington. British Dental Journal 167(10):341-344(1989). Descriptors: human, pig, local anesthesia, modified sterling syringe, ligmaject syringe. 507 "Technical aspects of cardiac catheterization of swine." A.C. Smith, F.G. Spinale, B.A. Carabello, and M.M. Swindle. Journal of Investigative Surgery 2(2):187-194(1989). Descriptors: indwelling catheters, heart catheterization, hemodynamics. 508 "A prototype device for nonimmersion shock wave lithotripsy using ultrasonography for calculus localization." F.F. Marshall, F. Weiskopf, A. Singh, F. Mark, F. Leo, R. Sanders, R. Makofski, P.C. Walsh, and N. Smith. Journal of Urology 140(2):249-253(1988). NAL call number: 448.8 J8234 Descriptors: ultrasound, transducer nephrolithiasis therapy, extracorporeal lithotripsy, renal calculi, nonoperative method, dwarf pigs, kidney stones. 509 "Swine as models in experimental surgery." M.M. Swindle, A.C. Smith, and B.J. Hepburn. Journal of Investigative Surgery 1(1):65-79(1988). Descriptors: anesthetic selection, housing, anatomic and physiologic characteristics. 510 "A technique to study splanchnic metabolism in the unrestrained conscious pig." C.L.H. van Berlo, A.E.J.M. van Bogaard, M.C.F. Bost, and P.B. Soeters. Laboratory Animal Science 38(4):463-466(August 1988). NAL call number: 410.9 P94. Descriptors: piglets, medical research, blood sampling techniques. 511 "Special anesthesia considerations of swine." J.C. Thurmon and G.J. Benson. In: Principles & Pracice of Veterinary Anesthesia C.E. Short (ed.), Williams & Wilkings, Baltimore, MD; 1987, p. 308-321. NAL call number: SF914 P7 Descriptors: restraint, tracheal intubation, preanesthetic medication, injectable anesthetics, combination of injectable agents, malignant hypothermia. 512 "Anesthesia in swine." T.W. Riebold and J.C. Thurmon. In: Swine in Biomedical Research M.E. Tumbleson (ed.), Vol. 1. Plenum Press, New York; 1986, pp. 243-254. NAL call number: RB125.C68 1985. Descriptors: tranquilizers, acetylpromazine, promazine, phenothiazine, azerpone, intravenous anesthesia, sodium thiamylal, sodium thiopental, pentobarbital, inhalants, nitrous oxide, halothane, endotracheal intubation, restraint, handling. 513 "Chronic swine instrumentation techniques utilizing the Gore- Tex peritoneal catheter." C.G. Gray, F.C. White, R.P. Crisman, J.B. Wisniewski, M.D. McKirnan, and C.M. Bloor. In: Swine in Biomedical Research M.E. Tumbleson (ed.), Vol. 1. Plenum Press, New York. 1986. pp. 279-290. NAL call number: RB125.C68 1985. Descriptors: sepsis, nonsterile catheter handling techniques, chronic vascular catheterization, skin interface device. 514 "Inhalant anesthesia for research swine." P.H. Eisele. In: Swine in Biomedical Research M.E. Tumbleson (ed.), Vol. 1. Plenum Press, New York; 1986, pp. 255-260. NAL call number: RB125.C68 1985. Descriptors: halothane, isoflurane, nitrous oxide, surgery, endotracheal tube. 515 "A method for administration of aerosols to anesthetized or unanesthetized swine." R.J. Lambert, V.R. Beasley, B.L. Kindler, R.H. Poppenga, G.R. Lundeen, M.L. Biehl, and R.M. Lorenzana. In: Swine in Biomedical Research M.E. Tumbleson (ed.), Vol. 1. Plenum Press, New York; 1986, pp. 201-208. NAL call number: RB125.C68 1985. Descriptors: endotracheal tube, halothane, lidocaine, soluble alcohol inhalation, inhalation chamber, transport cart. 516 "A multi-isotope procedure for simultaneously estimating the volume of body fluid compartments of swine." C.A. Bossone and J.P. Hannon. In: Swine in Biomedical Research M.E. Tumbleson (ed.), Vol. 1. Plenum Press, New York; 1986, pp. 49-59. NAL call number: RB125.C68 1985. Descriptors: splenectomized pigs, chronically implanted carotid artery catheter, Cr labelled red blood cells, plasma volume, hematocrit. 517 "Porcine models in surgical research: An overview." M.M. Swindle. In: Swine in Biomedical Research M.E. Tumbleson (ed.), Vol. 1. Plenum Press, New York; 1986, pp. 235-242. NAL call number: RB125.C68 1985. Descriptors: organ transplantation, plastic and reconstructive surgery, cardiovascular, genitourinary, gastrointestinal and pediatric surgery, interventional radiology. 518 "Pulse monitoring, intravascular, and intramuscular injection sites in pigs." D.L. Bobbie and M.M. Swindle. In: Swine in Biomedical Research M.E. Tumbleson (ed.), Vol. 1. Plenum Press, New York; 1986, pp. 273-277. NAL call number: RB125.C68 1985. Descriptors: blood sampling, auricular, brachial, carotid, femoral, and saphenous arteries, cranial vena cava. 519 "Restraint technique for intranasal inoculation and nasal culture of ten to twenty kilogram pigs." E.P. Noyes and M.Fuentes. In: Swine in Biomedical Research M.E. Tumbleson. Vol. 1. Plenum Press, New York; 1986, pp. 167-172. NAL call number: RB125.C68 1985. Descriptors: handling, restraint device, culture techniques, vaccination, bordetella bronchiseptica, Pasteurella Multocida, atrophic rhinitis, pneumonia. 520 "Die buprenorphin lachgas sauerstoff narkose am tiermodell hausschwein. [Buprenorphine and nitrous oxide oxygen anesthesia on an animal model--domestic pig.]" E. Pfenninger, A. Grunert, W. Muller, and W. Siegler. Zeitschrift fur Versuchstierkunde 26(2):67-76(1984). NAL call number: 410 Z36. Descriptors: piglets, narcosis, heart rate, arterial pressure, electrolyte and acid-base values. 521 "Swine as replacements for dogs in the surgical teaching and research laboratory." M.M. Swindle. Laboratory Animal Science 34(4):383-385(1984). Descriptors: basic operative surgery course, education. 522 "Anesthesia and euthanasia." M.M. Swindle. In: Basic Surgical Exercises Using Swine Praeger Publishers, New York; 1983, pp. 19-26. NAL call number: RD29.5 S94S94 Descriptors: preoperative care, preanesthetic drugs, injectable anesthetics, inhalation anesthesia, endotracheal intubation, postoperative care. 523 "Instrumentation." M.M. Swindle. In: Basic Surgical Exercises Using Swine Praeger Publishers, New York. 1983. pp. 57-67. NAL call number: RD29.5 S94S94 Descriptors: sponge holding forceps, towel clamps, scalpel, hemostatic forceps, intestinal clamps, cardiovascular clamps, retractors. 524 "Methods of tying knots." M.M. Swindle. In: Basic Surgical Exercises Using Swine Praeger Publishers, New York. 1983. pp. 27-44. NAL call number: RD29.5 S94S94 Descriptors: two-handed method--right-handed person, two- handed method--left-handed person, one-handed method--right- handed person, one-handed method, left-handed person. 525 "Operative procedures." M.M. Swindle. In: Basic Surgical Exercises Using Swine Praeger Publishers, New York. 1983. pp. 77-218. NAL call number: RD29.5 S94S94 Descriptors: skin incisions, reconstructive surgery, tenorrhaphy, abdominal incisions, cholecystectomy, spienectomy, abdominal vagotomy, gastrojejunostomy, pyloroplasty, nephrectomy, cystotomy, pneumonectomy, vasectomy, castration, tracheostomy. 526 "Principles of sterile surgery." M.M. Swindle. In: Basic Surgical Exercises Using Swine Praeger Publishers, New York. 1983. pp. 7-15. NAL call number: RD29.5 S94S94 Descriptors: wound healing, surgical pack preparation, sterilization, aseptic preparation. 527 "Suture materials and suture needles." R.J. Adams. In: Basic Surgical Exercises Using Swine Praeger Publishers, New York. 1983. pp. 47-54. NAL call number: RD29.5 S94S94 Descriptors: absorbable sutures, nonabsorbable sutures, sterilization, suture needles. 528 "Suture patterns and ligation techniques." M.M. Swindle. In: Basic Surgical Exercises Using Swine Praeger Publishers, New York. 1983. pp. 69-73. NAL call number: RD29.5 S94S94 Descriptors: hemostasis, closure of stumps, suture methods. 529 "Use of swine in surgical laboratories." M.M. Swindle. In: Basic Surgical Exercises Using Swine Praeger Publishers, New York, 1983. pp. 1-6. NAL call number: RD29.5 S94S94 Descriptors: laws, regulations, physiologic parameters, surgical anatomy, restraint. ------------------------------------------------------------- PRODUCTION, MANAGEMENT, BREEDING AND WELFARE 530 "The effect of space restriction and provision of toys during rearing on the behaviour, productivity and physiology of male pigs. G.P. Pearce and A.M. Paterson. Applied Animal Behaviour Science 36(1):11-28(1993). NAL call number: QL750.A6 Descriptors: stress, welfare, abnormal behavior, blood chemistry, hydrocortisone, boars, growth rate, pig housing, space requirements. 531 "Effect of enrichment and pen size on behavior productivity and immune response of growing-finishing pigs." B.Pedersen, S.E. Curtis, K.W. Kelley and H.W. Gonyou. Journal of Animal Science 70(Supplement 1):49(1992). NAL call number: 49 J82 Descriptors: conference paper, environmental enrichment, weight gain, growth. 532 "Effects of environmental enrichment on growing pigs." I. Horrell. Animal Production 54(3):483(1992). NAL call number: 49 AN55 Descriptors: abstract, behavior, rooting, inanimate object, space requirements. 533 "The influence of pen size on toy preference on growing pigs." J.K. Apple and J.V. Craig. Applied Animal Behaviour Science 35(2):149-155(November 1992). NAL call number: QL750.A6 Descriptors: pig housing, stocking density, play, stress, abnormal behavior. 534 "The seeking of novelty and its relation to play." D.G.M. Wood-Gush and K. Vestergaard. Animal Behaviour 43(4):599-606(October 1991). NAL call number: 410 B77 Descriptors: play, exploration, curiosity, welfare. 535 "Behaviour-environment relationships in pigs: Importance for the design of housing management systems in intensive husbandry." M.C. Meunier-Salaun and R. Dantzer. Pig News and Information. 11(4):507-513(December 1990). NAL call number: SF391.P55 Descriptors: animal behavior, pig housing, husbandry, age differences, welfare. 536 "Effect of environment enrichment on aggression in newly weaned pigs." A.L. Schaefer, M.O. Salomons, A.K.W. Tong, A.P. Sather and P. Lepage. Applied Animal Behaviour Science 27(1/2):41-52(August 1990). NAL call number: QL750.A6 Descriptors: toys, aggressive behavior, postweaning interval. 537 "Effects of mixing unfamiliar individuals and of azaperone on the social behaviour of finishing pigs." S.S.L. Tan and D.M. Shackleton. Applied Animal Behaviour Science 26(1/2):157-168(March 1990). NAL call number: QL750.A6 Descriptors: social behavior, social structure, mixing groups, agonistic behavior. 538 "Social contact requirements of domestic pigs assessed by behavioral demand functions." J. Ladewig and L. Matthews. Current Topics in Veterinary Medicine and Animal Science. 53:25-30(1990). NAL call number: SF600.C82 Descriptors: social interaction, psychological needs. 539 "Social recognition, social dominance and the motivation of fighting by pigs." J. Rushen. Current Topics in Veterinary Medicine and Animal Science. 53:135-143(1990). NAL call number: SF600.C82 Descriptors: social interactions, aggressive behavior. 540 "Swine housing and facilities January 1985-August 1990." J.C. Swanson. Quick Bibliography Series (USDA, NAL) 91-15:30p. (November 1990). NAL call number: aZ5071.N3 no.91-15 Descriptors: bibliography, flooring, crate design, ventilation, temperature control, manure handling. 541 "Welfare, care and husbandry of swine January 1979-August 1990." J.C. Swanson. Quick Bibliography Series (USDA, NAL) 91-14:20p. (November 1990). NAL call number: aZ5071.N3 no.91-14 Descriptors: bibliography, behavior, handling, transport, slaughter, housing. 542 "The influence of pleasant and unpleasant handling and the provision of toys on the growth and behaviour of male pigs." G.P. Pearce, A.M. Paterson, and A.N. Pearce. Applied Animal Behaviour Science 23(1/2):27-37(May 1989). NAL call number: QL750.A6 Descriptors: animal behavior, pig housing, boars, handling, stress factors, growth. 543 "The pig: A model for discussing animal behaviour and welfare." G. Van Putten. Applied Animal Behaviour Science 22(2):115-128(February 1989). NAL call number: QL750.A6 Descriptors: animal husbandry, housing, stress, behavior, welfare. 544 "Environmental enrichment for pigs: Differences in somatosensory cortical neurons and subsequent behaviour." T. Grandin, S.E. Curtis, W.T. Greenough. In Proceedings of the VIth International Congress on Animal Hygiene I. Ekesbo (ed.), Vol. 2, Skare, Sweden. June 14-17, 1988. pp.692-695. NAL call number: Descriptors: piglets, cortex, stimulation, environment, behavior. 545 "Breeding program and population standards of the Gottingen miniature swine." P. Glodek. In: Swine in Biomedical Research M.E. Tumbleson (ed.), Vol. 1. Plenum Press, New York. 1986. pp. 23-37. NAL call number: RB125.C68 1985. Descriptors: Gottingen miniature swine, breeding, boars, sows, body weight, litter size. 546 "Commercial pig pen modifications for housing miniature swine during chronic studies." H.A. Semple, R. Berzins, R.T. Coutts, D.C. Secord, and Y.K. Tam. In: Swine in Biomedical Research M.E. Tumbleson (ed.), Vol. 1. Plenum Press, New York. 1986. pp. 153-157. NAL call number: RB125.C68 1985. Descriptors: chronic implants, blood sampling, pharmacokinetic studies, confinement unit, design, modifications. 547 "Conceptual and operational history of the development of miniature swine." D.C. England and L.M. Panepinto. In: Swine in Biomedical Research M.E. Tumbleson (ed.), Vol. 1. Plenum Press, New York; 1986, pp. 17-22. NAL call number: RB125.C68 1985. Descriptors: feral populations, domestic stock, breeding, genetics, performance. 548 "Development of a computerized system for managing a research swine herd." J.L. Beamer and A.L. Slavich. In: Swine in Biomedical Research M.E. Tumbleson (ed.), Vol. 1. Plenum Press, New York; 1986, pp. 223-228. NAL call number: RB125.C68 1985. Descriptors: data management system, husbandry, genealogy data, breeding schedules, farrowing dates, baseline biological measurements, growth, hematology, computer technique. 549 "Endocrine and behaviour changes associated with intensive housing systems for swine." B.A. Becker, J.J. Ford, J.A. Nienaber, G.L. Hahn, and R.K. Christenson. In: Swine in Biomedical Research M.E. Tumbleson (ed.), Vol. 1. Plenum Press, New York; 1986, pp. 173-189. NAL call number: RB125.C68 1985. Descriptors: gilts, sows, behavior, pig housing, intensive husbandry, tether stalls, ACTH, cortisol, dexamethasone. 550 "Laboratory methodology and management of swine in biomedical research." L.M. Panepinto. In: Swine in Biomedical Research M.E. Tumbleson (ed.), Vol. 1. Plenum Press, New York; 1986, pp. 97-109. NAL call number: RB125.C68 1985. Descriptors: husbandry, restraint devices, tethering, stress, blood sampling techniques, housing, welfare, nutrition. 551 "Metabolism unit, confinement unit and placement of indwelling catheters for use with swine." J.M. Terris, T.V. Martin, and R.C. Simmonds. In: Swine in Biomedical Research M.E. Tumbleson (ed.), Vol. 1. Plenum Press, New York; 1986, pp. 111-121. NAL call number: RB125.C68 1985. Descriptors: housing, portable confinement unit, metabolism cage, blood sampling techniques, catheter placement, jugular vein, carotid artery, femoral artery and vein. 552 "Moral, social and scientific aspects of the use of swine in research." B.E. Rollin. In: Swine in Biomedical Research M.E. Tumbleson (ed.), Vol. 1. Plenum Press, New York; 1986, pp. 29-37. NAL call number: RB125.C68 1985. Descriptors: welfare, handling, scientific validity, ethics, standards, behavior, stress. 553 "The pig as a model for behavioural research." R. Dantzer. Laboratory Animal Science 36(4):366-369(August 1986). NAL call number: 410.9 P94 Descriptors: aggressive, sexual, social, feeding, and thermoregulatory behavior. 554 "Specialized management of a miniature swine herd for the EPRI electric field study." J.L. Beamer and V.G. Horstman. In: Swine in Biomedical Research M.E. Tumbleson (ed.), Vol. 1. Plenum Press, New York; 1986, pp. 217-221. NAL call number: RB125.C68 1985. Descriptors: Hanford miniature swine, 60 Hz electric field, high voltage transmission line simulation study, long term study, behavior, husbandry, breeding, baseline reproductive and growth parameters. 555 "The Yucatan miniature pig: Characterization and utilization in biomedical research." L.M. Panepinto and R.W. Phillips. Laboratory Animal Science 36(4):344-347(August 1986). NAL call number: 410.9 P94. Descriptors: breeds, selection, glucose tolerance, diabetes. 556 "The kangaroo island south australia strain of pig in biomedical research." G.H. Mcintosh and A. Pointon. Australian Veterinary Journal 57(4):182-185(April 1981). NAL call number: 41.8 AU72. Descriptors: breeding, feral pigs, large white, piggery, physiology, plasma sodium, potassium, glucose, urea, creatine, bleeding. AUTHOR LIST Aarnio, P. 151 Abd-Elfattah, A.S. 50 Abdesselem, R. 479 Aberg, M. 468 Ackerman, D.M. 361 Adam, W.E. 260 Adams, G.R. 76 Adams, R.J. 7, 527 Adler, L.P. 59 Aguggini, G. 164, 170, 460 Aherne, F.X. 340 Aiello, R.J. 27 Akai, M. 486 Al-Saady, N. 126, 175, 262 Albanese, M.A. 505 Albertini, A. 93 Albrightson-Winslow, C. 455 Alizadeh, H. 478 Allan, D.G. 338 Allen, W.C. 332, 493 Almdahl, S.M. 246 Alonso, F. 296 Alving, K. 160 Ameika, J.A. 186, 499 Amoss, M. 358, 362 Amplatz, K. 411 Andersen, O.K. 145 Anderson, M.E. 390 Anderson, R.H. 17, 33, 375 Andersson, M. 84, 456 Andre-Bougaran, J. 215 Andriole, V.T. 284 Angelini, G.D. 67 Angell-James, J.E. 500 Anggard, A. 159 Apple, J.K. 533 Arai, M. 446 Arce, D. 202 Argenzio, R.A. 199, 201, 203 Armour, J.A. 82 Armstead, W.M. 393 Arnold, A.J. 268 Arp, L.H. 301 Artwohl, J. 193, 212, 421 Ascher, S.E. 315 Atkinson, J.B. 158, 403 Attie, A.D. 27, 102 Audorf, F. 285 Aulick, L.H. 372 Baandrup, U. 63 Bada, H. 475 Badenhorst, E. 75 Badimon, J.J. 78 Badimon, L. 35, 78, 81 Bagchi, M. 91 Bahoric, A. 165 Bailey, R.W. 109, 494 Baisi, A. 502 Balaraman, V. 149 Banck, G. 354 Banks, A.K. 29 Barb, C.R. 294 Barbaric, Z. 267 Bardaji, A. 95 Barenbrug, H.W.M. 237 Barfod, K. 310 Barker, P.B. 263 Barnett, J.L. 330 Barrat, F. 215 Barrington, K.J. 382 Bass, J.L. 411 Basta, G. 217 Bates, M.A. 26 Bates, P.C. 243 Baum, J. 480 Bayer, T. 153 Beall, P. 198 Beam, T.E. 225 Beamer, J.L. 548, 554 Beasley, V.R. 515 Beattie, C.W. 358, 362 Becker, B.A. 326, 327, 549 Becker, C.D. 228 Beckmann, M.W. 212 Bekmukhametova, Z.U. 278 Belanger, M.P. 41 Ben-Efraim, S. 128 Benassai, C. 211 Benestad, H.B. 317 Benevenga, N.J. 249 Bennett, E.D. 126, 175, 262, 440 Benson, G.J. 331, 511 Benson, L.M. 364 Bentson, J. 473 Bergamini, E. 88 Berggren, P. 172 Bergh, I. 471 Berkelhammer, J. 366 Berkowitz, I.D. 396 Bermejo, A. 483 Bernard, S. 174, 303 Berns, A.J.M. 299, 304, 307 Berrebi, C. 352 Berthon, P. 174, 303 Bertram, T.A. 177 Berzins, R. 546 Betzler, H. 190, 245 Bevill, R.F. 233 Beynen, A.C. 254 Bhende, M.S. 404 Biederman, W.W.R. 34, 100 Biehl, M.L. 515 Bilello, J.F. 438 Binns, R.M. 322, 323 Bird, S.P. 241 Birndorf, M. 342 Bissett, D.L. 374 Bittle, B.K. 448 Black, D.D. 384 Blank, M. 185 Blocher, C.R. 155 Bloor, C.M. 25, 108, 137, 513 Bobbie, D.L. 518 Bobilya, D.J. 332, 493 Bocher, R. 337 Bodison, D.R. 34 Boedicker, J.J. 167 Boissy, R.E. 357 Bollinger, C. 75 Bom, A.H. 87 Bonta, I.L. 128 Booth, D.C. 43 Boratynski, Z. 290, 291, 292 Bording, A. 310 Borgren, H.G. 120 Borzone, A. 70 Bosschaerts, L. 431 Bossone, C.A. 4, 134, 138, 516 Bost, M.C. 195, 510 Botvinick, E.H. 89 Bourdillon, M.C. 98 Bourdon, R. 423 Bourne, F.G. 319 Bowdler, I. 426 Bowman, C.M. 158, 403 Bowman, T.A. 116 Boyd, J.B. 496 Bracher, M. 213, 221 Brading, A.F. 266 Brannan, M.D. 96 Bratlid, D. 397 Braun, E.R. 54, 74 Braxton, M. 28 Braymann, K. 210 Brendel, W. 24, 80 Brennan, J.J. 340 Brennecke, R. 120 Breslow, M.J. 135 Breu, W. 153 Breyer, R.H. 91 Brickson, B. 455 Brightwell, J.R. 361 Brock, J.M. 229 Brockmeier, S.L. 300 Broelsch, C. 193, 421 Brown, C.G. 51 Brown, G.L. 361 Brown, M. 390 Brown, R. 72 Brown, R.H. 328 Brownless, S.M. 268 Bruland, O.S. 317 Brunet, T.I.P. 217 Bryan, H.G. 455 Bubrick, M.P. 439 Buckley, T.M. 176 Buckner, P.S. 382 Budney, D. 338 Buie, W.D. 184 Bulkley, G.B. 109, 277 Buller, T.P. 346 Burchell, S.A. 22 Burhenne, H.J. 228 Burhop, K.E. 256 Burney, B.T. 191, 214 Burns, R.P. 482, 489 Burris, J.A. 225 Bursch, J.H. 120 Bush, L.W. 364 Busija, D.W. 393, 475 Bustad, L.K. 12 Bustamante, S.A. 387, 388 Butler, J.E. 324 Byrne, K. 155 Cai, Y.C. 94 Calafiore, R. 217 Calcinaro, F. 217 Caldwell, N. 455 Camacho, S.A. 62, 89 Cambier, J.C. 324 Cameron, D.E. 28 Camp, C.T. 276 Campbell, A.J. 205, 240 Campbell Jr., D.A. 226 Canals, A. 296 Capdeville, R. 215 Carabello, B.A. 21, 34, 100, 507 Carey, P.D. 155 Carlolan, B. 498 Carlsson, A. 471 Carton, E.G 124 Carty, H.M. 268 Case, C.L. 488 Castagneto, M. 70 Castiglioni, G.C. 70 Cazzaniga, A. 353 Ceconi, C. 93 Cerda, J. 485 Cervoni, P. 48 Chaiarla, C. 70 Chambers, M.M. 350 Chan, G. 383 Chan, P.S. 48 Chandler, J.P. 428 Chandler, K.E. 489 Chandrasena, L.G. 139 Chang, P. 305, 432 Chantarojanasiri, T. 396 Chaplin, R.K. 287 Charles River Laboratories 6 Charles, T.T. 179 Chartier, C. 157 Chavapil, M. 344 Chavapil, T.A. 344 Chavassieux, P. 334 Checovich, W.J. 27 Chellquist, E.M. 371 Chen, W.Y.J. 349 Cheng, S.F. 402 Cheng, W. 28 Chengappa, M.M. 315 Chesebro, J.H. 35, 49, 81 Cheung, A.K. 136 Cheung, H.S. 336 Chiang, S.H. 398 Chiu, R.C. 171 Chokshi, S.K 56 Chow, E. 32, 61 Craig, J.V. 533 Chrenshaw, T.D. 341 Christenson, R.K. 293, 326, 327, 549 Christophi, C. 222 Christou, N.V. 40 Chuang, G.J. 171 Church, W.R. 144 Cinca, J. 95 Cisek, E.P. 305, 432 Clarke, R.H. 101 Clarke, S.D. 398 Clarkson, T.B. 114 Clausen, M. 260 Clement, M.C. 170 Clement, M.G. 164 Clemente, G. 180 Cloutier, C.T. 169 Coetzee, A. 75 Coetzee, J. 75 Coffey, M.T. 399 Coghlan, L. 182 Cohen, H.L. 185 Cohen, I.T. 178, 379, 381 Colledan, M. 502 Compton, P.G. 32 Condemi, G. 185 Connors, B. 265 Constantinou, C.E. 281 Contreras, A. 174, 303 Conzen, P.F. 24, 80 Cook, D.R. 314 Cook, J.A. 39 Cook, R.G. 489 Cools, V. 197, 407 Corbett, R.J. 389 Corin, W. 34, 100 Cornelius, S.G. 398 Cornell, C.P. 305, 432 Cote, S. 309 Counihan, T.C. 178, 381 Coutts, R.T. 546 Cox, E. 197, 407 Crawford, F.A. 22, 23, 39, 490 Crisman, R.P. 513 Crocker, S.H. 169 Cromeens, D.M. 97 Cross, F. 56 Crucitti, F. 180 Cubero, M.J. 174, 303 Cuenoud, H.F. Curello, S. 93 Curstedt, T. 172 Curtis, S.E. 531, 544 Curtsinger III, L. 361 Cymerman, A. 451 D'Andrea, G. 70 Dachman, A.H. 225 Dafoe, D.C. 226 Dahm, M. 65, 394 Dai, J. 92 Daily, P.O. 107 Damia, G. 502 Damiano, B.P. 96 Danes, B.S. 373 Dangel, P. 161, 406 Dantzer, R. 535, 553 Danylenko, M.P. 64 Darlow, B.A. 242, 391 Darr, D. 346 David, R.B. 267 Davis, E.A. 18 Davis, S.C. 353 Dawe, E.J. 504 De Ley, J. 431 De Tata, V. 88 De Velde, C.J.H. 237 De Wind, N. 299, 304 Dean, E.A. 301 Dean, J.M. 396 Decammiere, C. 431 Dedecke, R. 77 Degroot, M.A. 89 DeJesus, S.T. 44, 101 DeLeo, M.A. 256 Demar, A.N. 43 Dembitsky, D.C. 107 Deshazer, J.A. 326 Deussen, A. 481 Devitt, P.G. 192 DeVore, D.P. 369 Dhall, D.P. 235 Dhalla, N.S. 92 Diano, E. 363 Diaz, C. 43 Dick, W. 121 Diehl, J.R. 295 Dieng, P.N. 157 Dillon, P.F. 76 Dion, J. 473, 501 Dipietro, S. 189 Dixon, J.A. 105 Djurhuus, C.J. 281 Dodds, W.J. 16, 146, 147, 148 Dolamore, B.A 242, 391 Domellof, L. 84, 456 Dominguez, J. 296 Dorer, A. 60 Dorion, D. 496 Dormer, K. 497 Dorsch, W. 153 Dowling, R.D. 492 Dreyer, C. 276 Dries, D.J. 105 Dubois, M. 220 Duckwiler, G. 473, 501 Dudgeon, D.L. 252 Duhault, J. 220 Dunnigan, P.M. 274 Durkot, M.J. 451 Duron, J.J. 220 Duston, S. 346 Dutet, D. 220 Dytko, G. 455 Eaglstein, W.H. 360, 365 Earley, D.L. 441 Easa, D. 149 Ebner, E. 132, 133 Eckersall, P.D. 416 Eckstein, J. 297 Edwards, S. 298 Eger II, E.I. 417, 433, 454 Eggleston, D.S. 455 Eide, T.J. 246 Eika, B. 457 Eika, B. 275 Einzig, S.S. 411 Eisele, P.H. 514 Eksborg, S. 84, 456 El-Damanhoury, S.H. 261 Elfenbein, I.B. 59 Elliot, S. 504 Elliott, N.C. 305, 432 Emde, C. 219 Emersen Jr, T.E. 83 Emerson, P. 158, 403 Engels, K. 121 England, D.C. 547 England, S.J. 165 Engleman, R.M. 91 Engler, R. 69 Engstrand, L. 183, 187 Engstrom, G.W. 253 Entman, M.L. 103 Ericsson, C.D. 179 Escalona, J. 347 Esyrev, O.V. 64 Evan, A.P. 265 Evans, O.B. 380 Evers, B. 209 Ewert, E. 311 Fabbri, L.P. 211 Falcini, F. 211 Falorni, A. 217 Fan, S.L. 94 Fan, S.X. 94 Farnum, C.E. 339 Farrar, D.J. 32, 61 Fass, D.N. 144 Fassbender, C.P. 444 Faulk, D. 390 Fay, R.S. 447 Fazel, A. 34 Fazi, T. 252 Fedorak, R.N. 184 Feeney-Burns, L. 482 Feisullin, S. 198 FŠlŠtou, M. 434 Feng, D.X. 94 Feng, J.F. 94 Fenninger, E. 426 Ferguson, D.B. 38, 442 Ferguson, D.M. 124 Ferguson, J.J. 36 Ferguson, R.M. 269 Ferrari, R. 93 Ferrell, L.D. 238 Fettman, M.J. 139 Field, J.G. 317 Field, M.J. 210 Fields, C.D. 44 Fierabracci, V. 88 Filipponi, F. 211 Filler, R.M. 165 Finkelstein, M. 377 Finn, K.C. 149 Fischman, M.A. 176 Fisher, K.R.S. 395 Fisher, M. 53 Fleisher, L.N. 392 Fleming, S.E. 202 Flieger, S. 290, 291, 292 Flo, C. 275, 457 Flye, M.W. 206 Foged, N.T. 310 Foppiano, L. 32 Forbes, R.B. 505 Ford, A.J. 281 Ford, J.J. 293, 326, 327, 549 Fornstedt, B. 471 Forster, W. 161, 406 Forsythe, J.L.R. 274 Forte, V.A. 451 Fortunato, M.A. 96 Foshola, T.O.A. 126, 262 Foster, D.M. 420 Foundation for Biomedical Research. 10 Fourie, P. 75, 213 Fourtanier, A. 352 Francis, D.H. 308 Franke, J. 335 Frankis, M. 100 Franklin, F.A. 252 Franklin, T.D. 191, 214 Fraser, A.G. 67 Friehs, G. 162 Frieling, G. 163 Frogley, J. 498 Frokiaer, J. 275, 457 Fry, F.J. 191, 214 Fuchs, G.J. 267 Fuentes, M. 166, 519 Fujimori, K. 465 Furgiuele, S. 180 Fuster, V. 35, 49, 81 Fyfe, D.A. 17, 375 Gai, B.K. 355 Gal, D. 20, 44, 101 Gallant, E.M. 447 Galliot, A.M. 423 Galmarini, D. 502 Galtier, P. 445 Gandhi, M.R. 405, 477 Ganter, M. 444 Ganz, J.C. 131, 472, 476 Gso, C.L. 482 Gao, C.X. 171 Garfin, S.R. 469 Gatti, S. 502 Gazmuri, R.J. 30 Geers, R. 431 Geinitz, D. 335 Geiser, D.R. 390 George-Nascimento, C. 361 Germann, E. 150, 491 Gerwirtz, H. 119, 122 Ghielmi, S. 93 Gibbons, D.G. 369 Gibbs, S.R. 33 Gielkens, A.L.J. 299, 304, 307 Gierscksky, E. 246 Gilbert, J.C. 238 Giles, G.R. 449 Gillespie, K.D. 150, 491 Gillette, P.C. 21, 488 Gilpin, E. 69 Gini, S. 88 Giovannini, I. 70 Glodek, P. 545 Gluck, G. 342 Gober, J.R. 62, 89 Goedseels, V. 431 Goerge, G. 79 Goerig, M. 218 Goetz, A.E. 24, 80 Goldman, S. 31 Goldstein, R.M. 252 Golz, D.I. 341 Gonschior, G.M. 24 Gonschior, P. 24, 80 Gonyou, H.W. 531 Gonzalez, J.M. 483 Gonzalez, O. 483 Goodwin, B.S. 359 Gootman, N. 82 Gootman, P.M. 82, 185 Gootz, T.D. 305, 432 Gori, Z. 88 Graeber, G.M. 52, 130 Graham, A. 40 Grandin, T. 544 Grant, S. 242, 391 Gray, C.G. 513 Green, C.J. 500 Green, C.T. 21 Greenough, W.T. 544 Griffith, S.L. 191, 214 Grill, D.E. 49 Grines, C.L. 43 Grosgogeat, Y. 98 Grosh, S.K. 369 Grossman, G. 172 Grunert, A. 426, 520 Grussner, R. 207, 259 Gubernatis, G. 209 Guidoin, R. 40 Guilarte, T.R. 252 Gulya, K. 385 Gurley, J.C. 43 Gurr, M.I. 241 Gustavsson, S. 183, 187 Guthy, E. 196 Guzzetta, P.C. 264, 333 Haberer, J.P. 157 Hadijisky, P. 98 Haggmark, S. 55, 84, 456 Hahn, G.L. 326, 327, 549 Halaburka, K.R. 101 Hall, M.R. 427 Hallett, K.G. 329 Hamby, C.V. 366 Hammainen, P. 151 Hammar, H. 356 Hammond, D. 342 Han, L.K. 269 Hanan, S.A. 50 Hand, M.S. 139 Hanke, C.W. 369 Hannon, J.P. 4, 123, 134, 138, 140, 516 Hansen, H.H. 275, 457 Hansen, T.W.R. 397 Hardy, S. 498 Harel, J. 309 Hargens, A.R. 469 Harjula, A. 151 Harmeyer, J. 247, 248, 280 Harrington, E. 506 Harrington, G.W. 233 Hartig, W. 190, 245 Haschke, R.H. 386 Hashiro, G. 149 Haskell, S.L. 305, 432 Hasler-Rapacz, J. 5 Hausman, D.B. 236 Haynie, D. 43 Haywood, G.A. 126, 262 He, Y. 478 Hebda, P.A. 360, 365 Hebiguchi, T. 252 Heikkila, L. 151 Heiligers, J.P.C. 87 Hein, E. 65, 394 Heintzen, P.H. 120 Heitkamp, D. 359 Heitz, J. 219 Helligso, P. 63 Hellman, J.M. 459 Hemsworth, P.H. 330 Henne-Bruns, D. 193, 421 Hennes, H.J. 261 Henning, S.J. 194 Henry, M.L. 269 Henze, R.E. 260 Hepburn, B.J. 8, 34, 509 Heras, M. 49, 81 Herfarth, C. 218 Herman, D.L. 399 Herren, C.H. 315 Herrmann, T. 152 Herslof, A. 84, 456 Hewick, R.M. 144 Hewitt, D. 241 Heydorn, W.Y. 107 Hickman, R. 213, 221, 276 Higa, T. 383 Higgins, R. 309 Hill, D.E. 413, 464 Hill, H.T. 314 Hill, J.D. 32 Hindahl, M.S. 305, 432 Hinder, R.A. 200 Hinderer, U.T. 347 Hinshaw, L. 154 Hirsh, M.P. 178, 379, 381 Ho, S.Y. 33 Hoban, L.D. 297 Hobbhahn, J. 24, 80 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